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Severe depression while pregnant reduces Vitamin D by 62 %, resulting in many problems in infant – June 2023


Serum Vitamin D status in full term neonates with severe perinatal depression

J Neonatal Perinatal Med. 2023 Jun 13. doi: 10.3233/NPM-230020 PDF behind paywall
P Batra 1, P Singh 1, R S Ahmed 2, D Harit 1

Background: Severe perinatal depression is a significant cause of mortality and morbidity in neonates. Vitamin D levels were observed to be low in mothers and their neonates with hypoxic ischemic encephalopathy in some studies, owing to its neuroprotective properties.

Objective: Primary objective was to compare vitamin D deficiency state in full term neonates with severe perinatal depression and healthy term controls. Secondary objectives were to determine sensitivity and specificity of serum 25(OH)D<12 ng/mL in predicting mortality, development of hypoxic ischemic encephalopathy, abnormal neurological examination at discharge, and developmental outcome at 12 weeks of age.

Material and methods: Serum 25(OH)D levels in full term neonates with severe perinatal depression and healthy controls were compared.

Results: Serum 25(OH)D levels in severe perinatal depression and controls (n = 55 each group) were significantly different (7.50 ± 3.53 ng/mL vs 20.23 ± 12.70 ng/mL).
At cut-off of < 12 ng/mL, serum 25(OH)D could predict

  • mortality with 100% sensitivity and 17% specificity and
  • poor developmental outcomes with sensitivity of 100% and specificity of 50%

Conclusion: Vitamin D deficiency status at birth can serve as an effective screening tool and poor prognostic markers in term neonates with severe


VitaminDWiki - 21 studies in both categories Depression and Pregnancy

This list is automatically updated


20 Intervention studies: Depression reduced by Vitamin D


VitaminDWiki – Depression contains

Some recent publications


17 Meta-analyses of Depression and Vitamin D, Omega-3, etc.


VitaminDWiki - Pregnancy category contains

887 items in Pregnancy category

 - see also


VitaminDWiki - Healthy pregnancies need lots of vitamin D contains

Problem
Vit. D
Reduces
Evidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial