TB has been increasing
There are many indications that vitamin D can both PREVENT and TREAT TB
- As with many other diseases, VitaminDWiki expects that there will be a at least a 4X range of vitamin D due to:
- 4X range in the response in the vitamin D blood level for the same IU dose - for healthy, non-obese, people
- Also expect that co-factors will prove to be very important
- UV appears to be as powerful or perhaps more powerful than vitamin D at TREATING TB
Table of contents
- See also VitaminDWiki
- See also web
- A. Martineau: TB and Vitamin D
- TB arrested by cod-liver oil (containing vitamin D) in 1848 was 3X better than other treatments at the time
- Vitamin D Receptor ApaI Gene Polymorphism and Tuberculosis Susceptibility: A Meta-Analysis (Feb 2014)
- TB Day review by Vitamin D Council March 2014
- TB Review at Vitamin D Council May 2014
- TB, Vitamin D and lipid metabolism (June 2014)
- Tuberculosis & Interleukin-32 – patent applied for – Aug 2014
See also VitaminDWiki
- Children with active TB were 4.6X more likely to have low vitamin D – Dec 2014
- TB conversion 6 percent less likely with just 1 ng more vitamin D – Oct 2014
- Less likely to catch Tuberculosis if have OK level of vitamin D – Nov 2014
- Tuberculosis, genes and vitamin D – Meta-Analysis Dec 2013
- All items in TB and vitamin D
- Tuberculosis associated with vitamin D deficiency – Nov 2013
- Tuberculosis varies with UVB in Australia - March 2013
- Tuberculosis, ethnic differences, and vitamin D – July 2013
- Vitamin D and infectious diseases like RTI, TB and Sepsis – Nov 2014
- Childhood TB prevention and treatment by vitamin D looks promising – 2012
- Probability of getting TB reduced 60 % with just 800 IU of vitamin D – RCT Aug 2012
- Multidrug-resistant tuberculosis may be reduced with vitamin D – Sept 2012
- TB worst in March, lowest vitamin D – CDC April 2012
- TB conversion 10X less likely if have sufficient vitamin D – Dec 2011
- Review of infectious diseases vitamin D trials – Feb 2012 TB and viral respiratory tract infections
- People with TB and one geneotype benefited more from 10,000 IU of vitamin D - Jan 2011
- Vitamin D from UVB lamps
- Vitamin D probably can prevent and treat TB and infectious diseases – 2012
- Study of TB seasonality over 28 years PDF is attached at the bottom of this page
- Early Clearance of Mycobacterium tuberculosis: a new frontier in prevention - 2013 PDF is attached at the bottom of this page
Vitamin D has been shown to prevent TB conversion
- Boron and Granulomas (TB, Rheumatoid arthritis, Crohn's, Rheumatic Fever etc.) - 2015
- TB in Wikipedia from a vitamin D perspective – Aug 2010 - which has the following graphic
Items in both categories TB and Intervention are listed here:
- Tuberculosis recovery speeded up by single 450,000 IU dose of vitamin D – RCT Jan 2017
- Tuberculosis treatment greatly helped by injection of 200,000 IU of vitamin D – RCT April 2016
- Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006
- Tuberculosis not treated by lots of vitamin D for 16 weeks – RCT Sept 2015
- Every TB patient benefited from 2 doses of 600,000 IU of vitamin D – RCT Jan 2013
- TB treatment helped with Vitamin D – RCT Sept 2012
- Probability of getting TB reduced 60 percent with just 800 IU of vitamin D – RCT Aug 2012
- Overview Tuberculosis and Vitamin D
- Evaluating the vitamin D evidence - Heaney Dec 2010
Pages listed in BOTH of the categoriesTB and Genetics
See also web
- Blacks born in Africa and moved to US had 27X higher rate of TB than people born in the US 2000-2009
- Clinical Trials: Tuberculosis AND "Vitamin D" INTERVENTION 24 trials Jan 2017
- Vitamin D Suplementation in TB Prevention Started Oct 2014
Using just 28,000 IU of vitamin D every 2 weeks (which is too little), 2800 children, 5 year study,
same dose for those weighing 50 lbs and those who weigh 150 lbs - dose should be proportional to weight
- Pulmonary Tuberculosis and Vitamin D - 60,000 IU weekly with Calcium
- A Clinical Trial to Study the Effect of the Addition of Vitamin D to Conventional Treatment in New Pulmonary Tuberculosis Patients 100,000 IU single dose
- Disease Database has lots of links to TB information (not vitamin D
- FoxNews on WHO and TB Sept 2011
kills around 1.7 million people a year. (7%)
Currently 1/5 of new cases are multidrug-resistant TB
officially reported cases of XDR-TB increased six-fold between 2008 and 2009
multidrug-resistant TB death rate is 50 percent
- Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatment PNAS Sept 2012
abstract describes vitamin D intervention clinical trial, details are behind a paywall
those who were taking vitamin D, taking an average of 23 days to become undetectable under the microscope
compared to 36 days in the patients who were taking the placebo.
- Vitamin D status and incidence of pulmonary tuberculosis, opportunistic infections, and wasting among Tanzanian adults initiating antiretroviral therapy Nov 2012
Puliminary TB 2.9X more likely if < 20ng of vitamin D
- What’s the Biggest World Pandemic Risk Today—Untreatable by Conventional Medicine? Sept 2012 Alliance for National Health
TB is second only to HIV as the leading infectious killer of adults worldwide
TB is the third largest cause of death among women aged 15 to 44.
Conventional medicine is panicking because TB is becoming resistant to multiple drugs and fear it may become “virtually untreatable.”
- 25-Hydroxyvitamin D levels after recovery from tuberculosis: Insights into pathogenesis. Nov 2013
People with prior TB had 25 ng of vitamin D, vs controls had 33 ng.
8 ng lower of dark skin, 9 ng lower if winter
- Association of vitamin D receptor BsmI gene polymorphism with risk of tuberculosis: a meta-analysis of 15 studies June 2013
BSML reduces risk of TB, pdf attached at the bottom of this page
TB cases increase in U.S. for first time in 23 years Washington Post March 2016
Nothing about vitamin D. Asian TB 280, whites TB 40 per million
No mention of darker skin and TB
- TB patients low on Vitamins D, A, and E - Nov 2016
Evaluation of Vitamin Status in Patients with Pulmonary Tuberculosis
Publisher wants $36 for the PDF
A. Martineau: TB and Vitamin D
- Search VitaminDWiki for Martineau 96 items as of May 2014
- The role of vitamin D in tuberculosis pathogenesis and treatment April 2014
A. Martineau, presented at 16th International Congress on Infectious Diseases - abstract-only online
32% of people are infected with TB
Vitamin D was used to treat TB in the pre-antibiotic era, and its active metabolite,
1,25-dihydoxyvitamin D, has long been known to enhance the immune response to mycobacteria in vitro.
Vitamin D deficiency is common in patients with active TB,
- A. Martineau organized the Vitamin D conference in England - April 23-25 2014
- Vitamin D and tuberculosis: more effective in prevention than treatment?
Int J Tuberc Lung Dis. 2015 Aug;19(8):876-7. doi: 10.5588/ijtld.15.0506.
Davies PD1, Martineau AR2. text not available for 6 months (Jan 2016)
TB arrested by cod-liver oil (containing vitamin D) in 1848 was 3X better than other treatments at the time
CLICK HERE if registered (free) for updated analysis of the 1848 study
Vitamin D Receptor ApaI Gene Polymorphism and Tuberculosis Susceptibility: A Meta-Analysis (Feb 2014)
Genet Test Mol Biomarkers. 2014 Feb 26.
Areeshi MY1, Mandal RK, Panda AK, Haque S.
Aim: Vitamin D performs its actions through the vitamin D receptor (VDR), which acts as a transcriptional factor. Many case-control studies have been performed in the past to elucidate the association of the ApaI polymorphism of VDR gene and the risk of tuberculosis (TB). However, these studies have shown inconsistent and conflicting results. In the present study, a meta-analysis was performed to investigate the potential relationship between the VDR ApaI gene polymorphism and the risk of TB.
Methodology: A quantitative synthesis was performed for the published studies based on the association between the VDR ApaI gene polymorphism and the risk of TB retrieved from PubMed (Medline) and EMBASE web databases. A meta-analysis was performed, and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for all the genetic models.
Results: We observed a decreased risk of TB in allelic contrast (a vs. A: p=0.009; OR=0.869, 95% CI=0.782 to 0.965), homozygous (aa vs. AA: p=0.006; OR=0.724, 95% CI=0.575 to 0.910), and heterozygous (aA vs. AA: p=0.698; OR=0.948, 95% CI=0.722 to 1.243) comparisons. Similarly, dominant (aa+Aa vs. AA: p=0.032; OR=0.842, 95% CI=0.720 to 0.985) and recessive (aa vs. AA+Aa: p=0.027; OR=0.796, 95% CI=0.650 to 0.975) models also demonstrated a decreased risk of TB, whereas a heterozygous genotype (Aa vs. AA: p=0.109; OR=0.873, 95% CI=0.740 to 1.030) did not indicate any association with the risk of TB. There was no evidence of publication bias and heterogeneity test.
Conclusions: This meta-analysis suggests that ApaI polymorphism of the VDR gene is significantly associated with a decreased risk of TB. However, future larger studies with groups of populations are warranted to analyze this association.
TB Day review by Vitamin D Council March 2014
Has the following infographic
TB Review at Vitamin D Council May 2014
- 1 in 3 people have latent TB
- 1 in 10 people with latent TB get TB (1 in 30 overall)
- More vitamin D has been associated with both prevention and treatment of TB,
Just as the sun has been long associated with TB prevention and treatment
TB, Vitamin D and lipid metabolism (June 2014)
Cutting Edge: Vitamin D Regulates Lipid Metabolism in Mycobacterium tuberculosis Infection.
J Immunol. 2014 Jun 4. pii: 1400736. Epub ahead of print
Salamon H1, Bruiners N2, Lakehal K2, Shi L3, Ravi J2, Yamaguchi KD1, Pine R4, Gennaro ML4.
Vitamin D has long been linked to resistance to tuberculosis, an infectious respiratory disease that is increasingly hard to treat because of multidrug resistance. Previous work established that vitamin D induces macrophage antimicrobial functions against Mycobacterium tuberculosis. In this article, we report a novel, metabolic role for vitamin D in tuberculosis identified through integrated transcriptome and mechanistic studies. Transcriptome analysis revealed an association between vitamin D receptor (VDR) and lipid metabolism in human tuberculosis and infected macrophages. Vitamin D treatment of infected macrophages abrogated infection-induced accumulation of lipid droplets, which are required for intracellular M. tuberculosis growth. Additional transcriptomics results showed that vitamin D downregulates the proadipogenic peroxisome proliferator-activated receptor γ (PPARγ) in infected macrophages. PPARγ agonists reversed the antiadipogenic and the antimicrobial effects of VDR, indicating a link between VDR and PPARγ signaling in regulating both vitamin D functions. These findings suggest the potential for host-based, adjunct antituberculosis therapy targeting lipid metabolism.
Copyright © 2014 by The American Association of Immunologists, Inc.
Tuberculosis & Interleukin-32 – patent applied for – Aug 2014This page is in the following categoriesTuberculosis
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