Table of contents
- ALS 5 X more likely if exposed to pesticides - JAMA May 2016
- ALS 4X worse if severely low Vitamin D - Nov 2013
- ALS 4X more likely in professional football players- June 2016
- Even 2,000 IU helped all 20 ALS patients in clinical trial - 2013
- Vitamin D Council - speculated on benefits of 20,000 IU on ALS
- Vitamin D as a potential therapy in amyotrophic lateral sclerosis (mouse ALS) – Feb 2014
- ALS varies with latitude - similar to most vitamin D related diseases
- ALS deaths increasing 60 % per decade - somewhat slower than other vitamin D related diseases
- ALS worse if lower level of vitamin D - June 2015
- See also VitaminDWiki
- ALS "Ice Washing" "nonprofit" executives each have an average salary of $173,000
- ALS survival not vary with vitamin D level (greater or less than 10 nanograms) - Aug 2016
ALS 5 X more likely if exposed to pesticides - JAMA May 2016
Association of Environmental Toxins With Amyotrophic Lateral Sclerosis JAMA Neurology
Questionare to 60 year olds - comparing ALS and non ALS
5X any pesticide exposure in 30 years
pentachlorobenzene: OR = 2.21;
cis-chlordane: OR = 5.74;
PCB 175: OR = 1.81;
PCB 202: OR = 2.11;
BFR (polybrominated diphenyl ether 47: OR = 2.69;
Military: OR = 2.31;
Sources of pesticides (from PDF)
Download the PDF from VitaminDWiki
Note: Pesticides lower Vitamin D. Vitamin D suplementation cancels some of the problem
See also VitaminDWiki Pesticides increase risk of Cancers, Alz, ALS, Asthma, ADHD, etc. (all related to low vitamin D) – Oct 2016
ALS 4X worse if severely low Vitamin D - Nov 2013
Amyotrophic lateral sclerosis has 4X faster decline if severely low Vitamin D – Nov 2013 has the following chart
Red line: < 25 nmol = <10 ng
ALS 4X more likely in professional football players- June 2016
- The Complicated Connection Between Football and ALS Atlantic
"professional football players are 4 X more likely to die of ALS than the general population"
"Hereditary factors explain only a small percentage of ALS cases."
"The head trauma hypothesis is bolstered by the fact that veterans appear to be more likely to develop ALS, as are soccer players."
Note by VitaminDWiki: many prefessional football players have low levels of vitamin D due to covered stadiums (lack of sun)
Even 2,000 IU helped all 20 ALS patients in clinical trial - 2013
Vitamin D deficiency and its supplementation in patients with amyotrophic lateral sclerosis.
J Clin Neurosci. 2013 Jun 28. pii: S0967-5868(13)00149-5. doi: 10.1016/j.jocn.2013.01.011.
Karam C, Barrett MJ, Imperato T, Macgowan DJ, Scelsa S.
Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: chafickaram at gmail.com.
We studied 25-hydroxyvitamin D (vitamin D) levels in patients with amyotrophic lateral sclerosis (ALS) and the effect of vitamin D supplementation. Vitamin D levels were checked in 37 consecutive patients with ALS. Demographic data, vitamin D supplementation, change in Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) score, and side effects from vitamin D were noted over a 9 month follow-up period. ALSFRS-R scores were compared between patients who took vitamin D and those who did not. The median age was 55 years and median time since symptom onset was 61 months. The mean vitamin D level was 22.3ng/mL (normal range, 30-80ng/mL). Eighty-one percent of patients had a vitamin D level lower than 30ng/mL and 43% had a vitamin D level lower than 20ng/mL.
Twenty patients took 2000 international units of vitamin D daily. After adjustment for age and baseline vitamin D levels in a linear regression model, the ALSFRS-R score decline was smaller in patients taking vitamin D at 9 months (p=0.02) but was not significantly different at 3 or 6 months. Median vitamin D levels rose from 18.5 to 31.0ng/mL at 6 months in the group taking vitamin D. No side effects secondary to vitamin D supplementation were reported. Vitamin D supplementation at 2000 international units daily was safe over a period of 9 months and may have a beneficial effect on ALSFRS-R scores. Further studies are warranted to determine whether there is a benefit in vitamin D supplementation for all ALS patients.
Copyright © 2013 Elsevier Ltd. All rights reserved.PMID: 23815870
Fig. 1. Graph showing change in median Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) score
before and after initiation of vitamin D supplementation,
with Time 0 being the commencement of supplements for the vitamin D group.
Comment by VitaminDWiki
2,000 IU of vitamin D took over 6 months to restore vitamin D levels - then the benefits could start
Would have been much faster if they has used a loading dose
ALSFRS-R score Calculator is calculated on the following aspects
1. Speech, 2. Salivation, 3. Swallowing, 4. Handwriting, 5. Cutting food with gastrostomy, 6. Dressing and hygiene
7. Turning in bed, 8. Walking, 9. Climbing stairs, 10. Dyspnea, 11. Orthopnea (sleeping), 12. Respiratory insufficiency
13. Number many years since onset of symptoms
Vitamin D Council - speculated on benefits of 20,000 IU on ALS
Vitamin D Council on ALS behind a $5/month paywall
After reviewing the article at the top of this page, Dr. Cannell speculates on benefits to ALS of 20,000 IU daily
Vitamin D as a potential therapy in amyotrophic lateral sclerosis (mouse ALS) – Feb 2014
CNS Neurosci Ther. 2014 Feb;20(2):101-11. doi: 10.1111/cns.12204.
Gianforcaro A1, Hamadeh MJ.
1School of Kinesiology and Health Science, Faculty of Health, and Muscle Health Research Centre, York University, Toronto, ON, Canada.
Vitamin D has been demonstrated to influence multiple aspects of amyotrophic lateral sclerosis (ALS) pathology.
Both human and rodent central nervous systems express the vitamin D receptor (VDR) and/or its enzymatic machinery needed to fully activate the hormone.
Clinical research suggests that vitamin D treatment can improve compromised human muscular ability and increase muscle size, supported by loss of motor function and muscle mass in animals following VDR knockout, as well as increased muscle protein synthesis and ATP production following vitamin D supplementation.
Vitamin D has also been shown to reduce the expression of biomarkers associated with oxidative stress and inflammation in patients with
- multiple sclerosis,
- rheumatoid arthritis,
- congestive heart failure,
- Parkinson's disease and
- Alzheimer's disease;
diseases that share common pathophysiologies with ALS.
Furthermore, vitamin D treatment greatly attenuates hypoxic brain damage in vivo and reduces neuronal lethality of glutamate insult in vitro; a hallmark trait of ALS glutamate excitotoxicity.
We have recently shown that high-dose vitamin D3 supplementation improved, whereas vitamin D3 restriction worsened, functional capacity in the G93A mouse model of ALS.
In sum, evidence demonstrates that vitamin D, unlike the antiglutamatergic agent Riluzole, affects multiple aspects of ALS pathophysiology and could provide a greater cumulative effect.
Download the PDF from VitaminDWiki
ALS varies with latitude - similar to most vitamin D related diseases
ALS deaths increasing 60 % per decade - somewhat slower than other vitamin D related diseases
Similar increases in many other vitamin D deficient diseases
For more disease increases see: Incidence of 30 health problems related to vitamin D has doubled in a decade
ALS worse if lower level of vitamin D - June 2015
Vitamin D is Not a Protective Factor in ALS
CNS Neurosci Ther. 2015 Jun 20. doi: 10.1111/cns.12423. [Epub ahead of print]
Blasco H1,2, Madji Hounoum B1, Dufour-Rainfray D1,3, Patin F1, Maillot F4,5, Beltran S6, Gordon PH7, Andres CR1,2, Corcia P1,6.
AIMS: Vitamin D deficiency has been associated with poorer prognosis in ALS. Better understanding of the role of vitamin D in ALS is needed to determine whether trials of systematic supplementation are justified. Our aim was to report vitamin D levels during the course of ALS and to evaluate its relationship with clinical parameters at diagnosis and with disease progression.
METHODS: We prospectively collected vitamin D serum concentrations from 125 consecutive ALS patients. Cox proportional hazard models analyzed the relationship between vitamin D concentrations, clinical parameters, and survival.
RESULTS: The mean vitamin D concentration was below our laboratory's lower limit of normal (P < 0.0001) and did not change during the course of the disease. The concentrations were higher in patients with bulbar onset (P = 0.003) and were negatively associated with body mass index (BMI) (P = 0.0095). Models with ALSFRS-R (ALS Functional Rating Scale-Revised) and BMI as a covariates showed that vitamin D concentrations predicted worse prognosis.
CONCLUSION: .The distribution of vitamin D concentrations in our cohort was consistent with previous reports. Surprisingly, we noted a negative effect of higher vitamin D levels on prognosis in ALS. More detailed research is warranted to determine whether manipulation of vitamin D could be beneficial to patients.
See also VitaminDWiki
- Search VitaminDWiki for "amyotrophic lateral sclerosis" 40 items as of June 2016
- Vitamin D and MS, ALS, Autism, Alzheimer’s and other nervous system diseases – review Aug 2013
- Amyotrophic lateral sclerosis has 4X faster decline if severely low Vitamin D – Nov 2013
- Incidence of 30 health problems related to vitamin D has doubled in a decade
- Traumatic brain injury treated by Vitamin D Progesterone Omega-3 and glutamine – May 2013 Matthews
- Overview Loading of vitamin D restore vitamin D levels in days, instead of months
Check that you are not allergic to vitamin D by trying a small amount - say 1,000 IU and seeing any reactions (only about 1 in 300 people are)
The brand vitamin D with the least amount of additives and no reported bad reactions is Bio-Tech - which also is the highest rated brand on Amazon
Of the few people with reactions to vitamin D, many appear to be deficient in Magnesium - Magnesium Chloride is a good supplement
A typical loading dose in 400,000 IU - can be, for example, be achieved by 50,000 IU capsules once a day for 8 days.
ALS "Ice Washing" "nonprofit" executives each have an average salary of $173,000
Details at Green Medical InformationGreenMedInfo
GreenMedInfo points out that ALS "non-profit" focuses on patentable treatments of ALS rather than natural supplements.
GreenMedInfo gives details on proven ALS treatments by Vitamins D, E, and B-12
ALS survival not vary with vitamin D level (greater or less than 10 nanograms) - Aug 2016
Vitamin D levels are not predictors of survival in a clinic population of patients with ALS.
J Neurol Sci. 2016 Aug 15;367:83-8. doi: 10.1016/j.jns.2016.05.007. Epub 2016 May 7.
Yang J1, Park JS2, Oh KW2, Oh SI3, Park HM4, Kim SH5.
1Department of Neurology, Gachon University, Gil Medical Center, 21, Namdong-daero, 774 Beon-gil, Namdong-gu, Incheon 21565, South Korea.
2Department of Neurology, College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea.
3Department of Neurology, Busan Paik Hospital, Inje University, 75, Bokji-ro, Busanjin-gu, Busan 47392, South Korea.
4Department of Neurology, Gachon University, Gil Medical Center, 21, Namdong-daero, 774 Beon-gil, Namdong-gu, Incheon 21565, South Korea. Electronic address: neurohm at gilhospital.com.
5Department of Neurology, College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, South Korea. Electronic address: kimsh1 at hanyang.ac.kr.
This study aimed to measure serum 25-hydroxyvitamin D 25(OH)D concentrations, bone mineral density (BMD), and the parameters of bone metabolism in amyotrophic lateral sclerosis (ALS) patients, and their correlation with survival.
We retrospectively analysed data of 100 ALS patients who consecutively visited a single referral ALS clinic between January and December 2011. Sex; age and site of symptom onset; and death were recorded. Serum 25(OH)D concentration was dichotomized as <10ng/ml and ≥10ng/ml.
There was absent relationship between serum 25(OH)D and concentration of bone turnover parameters or between 25(OH)D and BMD. According to the results of the Kaplan-Meier analysis with log-rank test, the survival rates of patients without (≥10ng/ml) and of those with severe vitamin D deficiency (< 10ng/ml) were not significantly different. Cox regression analysis showed that a poor prognosis was most correlated with older age at onset and bulbar onset after adjustment for all the clinical factors.
In conclusion, vitamin D levels were not correlated to other bone markers and survival in a clinic population of ALS patients.
Copyright © 2016 Elsevier B.V. All rights reserved. PMID: 27423568