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Overview Metabolic Syndrome and vitamin D

WikiPedia Metabolic Syndrome

Metabolic syndrome is a combination of medical disorders that, when occurring together, increase the risk of developing cardiovascular disease and diabetes
It affects one in five people in the United States and prevalence increases with age.
Some studies have shown the prevalence in the USA to be an estimated 25% of the population
Many different definitions of Metabolic Syndrome
{which include some combination of Diabetes, obesity, hypertension, Elevated triglycerides,High-sensitivity, C-reactive protein, Reduced HDL cholesterol}

See also VitaminDWiki

See also Clinical Trials for Metabolic Syndrome

Metabolic Syndrome 13% more likely for each 10ng decrease in vitamin D - meta-analysis of cross sectional studies March 2014

Blood vitamin D status and metabolic syndrome in the general adult population: a dose-response meta-analysis.
J Clin Endocrinol Metab. 2014 Mar;99(3):1053-63. doi: 10.1210/jc.2013-3577. Epub 2013 Jan 1.
Ju SY1, Jeong HS, Kim do H.
1Department of Family Medicine (S.Y.J.), Yeouido St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 150-713, Korea; Department of Preventive Medicine (H.S.J.), Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea; and Department of Family Medicine (D.H.K.), Korea University Ansan Hospital, Korea University College of Medicine, Seoul 136-705, Korea.

  • CONTEXT: Increasing evidence has suggested an association between blood vitamin D levels and metabolic syndrome.
  • OBJECTIVE: Our objective was to determine the relationship between blood vitamin D status and metabolic syndrome in the general adult population, using a dose-response meta-analysis.
  • DATA SOURCE: We searched the PubMed, EMBASE, Web of Science, and Cochrane Library databases through July 2013 to identify relevant studies.
  • STUDY SELECTION: Observational studies, reporting risk ratios with a 95% confidence interval (CI) for metabolic syndrome in ≥3 categories of blood 25-hydroxyvitamin D [25(OH)D] levels, were selected.
  • DATA EXTRACTION: Data extraction was performed independently by 2 authors, and the quality of the studies was evaluated using the risk of bias assessment tool for nonrandomized studies.
  • DATA SYNTHESIS: The pooled odds ratio of metabolic syndrome per 25 nmol/L increment in the serum/plasma 25(OH)D concentration was 0.87 (95% CI = 0.83-0.92, I(2) = 85%), based on 16 "cross-sectional studies" and 1.00 (95% CI = 0.98-1.02, I(2) = 0%) for 2 "cohort and nested case-control studies." The dose-response meta-analysis showed a generally linear, inverse relationship between 25(OH)D levels and metabolic syndrome in the cross-sectional studies (P for linear trend < .001).
  • CONCLUSIONS: Blood vitamin D levels were associated with a risk of metabolic syndrome in cross-sectional studies but not in longitudinal studies. Randomized, clinical trials will be necessary to address the issue of causality and to determine whether vitamin D supplementation is effective for the prevention of metabolic syndrome.

PMID: 24423309

Some PubMed items

Metabolic Syndrome and Fructose - Mercola Jan 2015

Health Tips from a Grizzly

  • I highly recommend reading Dr. Richard Johnson's book The Fat Switch (2012)
  • Johnson: metabolic syndrome really should be called the fat-storage condition, because it’s just fat storage.
  • Johnson video March 2014
  • Humans share the genes with other animals which use fructose to store fat
  • However, humans lack the ability to turn off the "fat switch" (most hypernating animals)
  • Recommends < 25 grams of frutose, and for some people < 15 grams

Metabolic Syndrome images from web (nothing about vitamin D)

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Overview Metabolic Syndrome and vitamin D        

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