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Vitamin D Receptor

183 items in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

A poor VDR increases the risk of 37 health problems  click here for details

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
You can compensate for poor VDR by increasing one or more of the following:

IncreasingIncreases
1) Vitamin D supplement
  Sun, Ultraviolet -B
Vitamin D in the blood
and thus to the cells
2) MagnesiumVitamin D in the blood
 AND to the cells
3) Omega-3 Vitamin D to the cells
4) Resveratrol Vitamin D to the cells
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor


See chart at the bottom of VDR page for Magnesium, Omega-3 and Resveratrol

If poor Vitamin D Receptor

Risk
increase
Health Problem
13Sepsis
9.6Chronic Periodontitis
   and smoke
7.6Crohn's disease
5.8Low back pain in athletes
5Ulcerative Colitis
5Coronary Artery Disease
4.6Breast Cancer
4polycystic ovary syndrome
3.3 Pre-term birth
3.1Lumbar Disc Degeneration
3.1Colon Cancer survival
3 Multiple Sclerosis
3Dengue
3 Waist size
3 Ischemic Stroke
3Alzheimer’s
2.8Osteoporosis
2.7Gastric Cancer
2.6Lupus in children
2.4Lung Cancer
2.3Autism
2Diabetic Retinopathy
2Parkinson's
2 Wheezing/Asthma
2 Melanoma   Non-melanoma Skin Cancers
2Myopia
1.9Uterine Fibroids
1.9Early tooth decay
1.8Diabetic nephropathy
1.6Diabetes - Type I
1.6Prostate Cancer while black
1.5 Diabetes -Type II
1.5Pertusus
1.4 Rheumatoid arthritis
1.3Childhood asthma
1.3Tuberculosis


Parkinson’s risk increased. . . has the following

FokI T > C rs 10735810
BsmI A > G rs 1544410
ApaI A > C rs 7975232
TaqI C > T rs 731236
none of these appear to be in the DNA test service 23andMe

20 Most-visited pages in VitaminD Receptor category

Id Page Hits Last modification Creator Categories
3439 Genetics 24841
06 Nov, 2017 11:16
ricks99 Genetics
Vitamin D Receptor
Vit D Binding Protein
Category
6760 Vitamin D Receptor 12880
12 Nov, 2017 22:55
admin Vitamin D Receptor
Category
3335 Vitamin D levels are strongly associated with genes: overview of twin studies – Nov 2012 10796
04 Jan, 2015 02:37
admin Genetics
Vitamin D Receptor
7065 Vitamin D and the skin: Focus on a complex relationship - Nov 2015 10347
15 May, 2017 00:00
admin Top news
Skin
Vitamin D Receptor
794 229 Genes related to vitamin D - Aug 2010 8445
08 Jan, 2015 16:24
admin Deficiency of Vitamin D
Overview for doctors
Vitamin D Receptor
4216 The vitamin D receptor and T cell function – June 2013 8207
11 May, 2017 00:50
admin Immunity
Vitamin D Receptor
3881 Vitamin D level can be high, but little benefit: due to kidney, genes, low Magnesium etc. 7695
28 Nov, 2014 19:11
admin Deficiency of Vitamin D
How much Vitamin D
Kidney
Vitamin D and Magnesium
Genetics
Top news
Vitamin D Receptor
Vit D Binding Protein
5287 10 reasons why seniors need more vitamin D 6453
12 Aug, 2017 15:50
admin Seniors
Top news
Vitamin D Receptor
3976 Vitamin D is suppressed by both Roundup and Genes 6348
25 Oct, 2017 15:43
admin Vitamin D Receptor
Glyphosate
6872 Intensely exercising muscles (rats) increases their vitamin D reception capability.– Sept 2015 6322
17 Oct, 2015 16:30
admin Sports and Vitamin D
Vitamin D Receptor
6306 Growth Hormone problem (Acromegaly) more likely if vitamin D gene problems problems – 2015 5602
12 Nov, 2017 18:27
admin Vitamin D Receptor
Vit D Binding Protein
5564 Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014 5443
23 Sep, 2016 13:30
admin Parkinson
Meta-analysis of Vitamin D
Cognitive
Vitamin D Receptor
4887 Vitamin D receptor may suppress skin cancer – Dec 2013 5231
27 Jan, 2017 18:43
admin Cancer - Skin
Vitamin D Receptor
5739 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014 5178
26 Oct, 2016 15:50
admin Parkinson
Meta-analysis of Vitamin D
Top news
Vitamin D Receptor
3490 Vitamin D Receptor genes bb and BB and Osteoporosis, esp. for blacks – meta-analysis Nov 2012 4964
05 Dec, 2016 16:09
admin Skin - Dark
Osteoporosis
Genetics
Meta-analysis of Vitamin D
Vitamin D Receptor
7403 Health problems that run in families are often associated with low vitamin D 4930
21 Apr, 2017 12:48
admin Health
Genetics
Top news
Vitamin D Receptor
Vit D Binding Protein
4983 Vitamin D Receptor role in Autoimmune Diseases and or cancers – Nov 2013 4838
28 Oct, 2017 11:25
admin Autoimmune
Cancer
Genetics
Vitamin D Receptor
5641 Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014 4820
25 Jul, 2017 16:06
admin Cancer - Pancreatic
Genetics
Top news
Vitamin D Receptor
3699 Calcium and vitamin D receptors are important to many health conditions – Jan 2013 4784
14 Nov, 2016 02:34
admin Health
Vitamin D and Calcium
Vitamin D Receptor
2651 10 percent of colon cancer linked to Vitamin D Receptor – meta-analysis April 2012 4511
23 Sep, 2016 14:33
admin Cancer - Colon
Meta-analysis of Vitamin D
Vitamin D Receptor

Genetics category listing contains the following

206 articles in Genetics the category

 

see also 183 articles in Vitamin D Receptor, 77 articles in Vitamin D Binding Protein

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki - (subject to many future developments)
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, andi in 2017 is speculated to be 90%
  • Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells appears feasible (personal communication)
    However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
       especially if it is one of 37+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are poor
    4) Back Pain
        probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
          The founder of VitaminDWiki took action with clues #3&4

Additional information on the Genes in VitaminDWiki

Gene# of pages
Oct 2017
Location
CPY27A1223 Liver
CYP2R1 626Tissue
Vitamin D Binding Protein 3,450 Blood
CYP27B1803Kidney & Tissue
Vitamin D Receptor 6,030Cell Tissue
CYP24A1 745 excrete excess


See also Vitamin D Binding Protein category listing has 77 items


In addition to inherited poor VDR genes, Herpes downregulates VDR by 8X for a short time

Note: Many people have Herpes but are not aware of it. (example: 48% of black women)

See also web

  • Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene Selfhacked Jan 2016 - has lots of linked references
    Includes Exercise, RXR ( and retinol) is needed to produce proteins with the VDR, SIRT1 -potentiates VDR, PGC-1a, Dopamine
    Bile, Omega-3: Omega-6:Curcumin, Resveratrol, Forskolin , Gamma Tocotrienol, Estradiol,
    What Inhibits The Vitamin D Receptor (VDR) or Calcitriol
    Caffeine , Cortisol/Glucocorticoids, Prolactin, Thyroid hormones,Corticosteroids decrease calcitriol,Phosphatonin, Ketoconazole, Heparin and Thiazides decrease
    Pathogens That Inhibit The Vitamin D Receptor include
    P. aeruginosa, H. pylori, Lyme/Borrelia – Live Borrelia reduces VDR by 50 times (in monocytes).
    Tuberculosis – Reduces VDR 3.3-fold.“Gliding” biofilm bacteria, Shigella, Mycobacterium leprase
    Epstein-Barr virus (EBV) – Decreases VDR by a factor of about five, HIV – binds to the VDR (R) and inhibits conversion to active D
    Aspergillus fumigatus – In cystic fibrosis patients,
    Cytomegalovirus – CMV decreases VDR 2.2 fold, Hepatitis C virus – Inhibits CYP24A1|Changes in vitamin D endocrinology during aging in adults] June 2017
  • Changes in vitamin D endocrinology during aging in adults June 2017
  • "Aging leads to a decrease in vitamin D receptor number in several organs."
    Interesting, details are behind a paywall
  • Calcitriol receptor = VDR Wikipedia
    "Glucocorticoids are known to decrease expression of VDR,"
    "Mutations in this gene are associated with type II vitamin D-resistant rickets"
    "The vitamin D receptor plays an important role in regulating the hair cycle."

PubMed

Light activates VDR at conception,etc. - April 2017
VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences.
Am J Hum Biol. 2017 Apr 22. doi: 10.1002/ajhb.23010. [Epub ahead of print]
Beckett EL1,2,3, Jones P1, Veysey M2,4, Duesing K3, Martin C1, Furst J5, Yates Z6, Jablonski NG7, Chaplin G7, Lucock M1.

OBJECTIVES:
The vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. We examined whether degree of VDR gene methylation acts as a molecular adaptation to light exposure. We explored this in the context of photoperiod at conception, recent UV irradiance at 305 nm, and gene-latitude effects.

METHODS:
Eighty subjects were examined for VDR gene-CpG island methylation density. VDR gene variants were also examined by PCR-RFLP.

RESULTS:
Photoperiod at conception was significantly positively related to VDR methylation density, explaining 17% of the variance in methylation (r2  = 0.17; P = .001). Within this model, photoperiod at conception and plasma 25(OH)D independently predicted methylation density at the VDR-CpG island. Recent UV exposure at 305 nm led to a fivefold increase in mean methylation density (P = .02). Again, UV exposure and plasma 25(OH)D independently predicted methylation density at the VDR-CpG island. In the presence of the BsmI mutant allele, methylation density was increased (P = .01), and in the presence of the TaqI or FokI mutant allele, methylation density was decreased (P = .007 and .04 respectively). Multivariate modelling suggests plasma 25(OH)D, photoperiod at conception, recent solar irradiance, and VDR genotype combine as independent predictors of methylation at the VDR-CpG island, explaining 34% of the variance in methylation (R2  = 0.34, P < .0001).

CONCLUSIONS:
Duration of early-life light exposure and strength of recent irradiance, along with latitudinal genetic factors, influence degree of VDR gene methylation consistent with this epigenetic phenomenon being a molecular adaptation to variation in ambient light exposure. Findings contribute to our understanding of human biology.

PMID: 28432711 DOI: 10.1002/ajhb.23010
Publisher rents PDF for $6


Big increase in PubMed papers with Vitamin D Receptor or VDR in the title
Image
2,987 studies had Vitamin D Receptor in the title as of Nov 2017
191 VDR studies added in 2017 (as of Nov)


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Vitamin D Receptor        

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8536 Vitamin D receptor-targeted treatment to prevent - - Diabetes.pdf PDF 2017 admin 11 Oct, 2017 20:14 6.46 Mb 22
7458 VDR papers.jpg admin 06 Dec, 2016 03:34 4.32 Kb 1256
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