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Allergy - Overview

Did you know?
  • Low vitamin D is strongly associated with most types of allergies
  • There is a 5 to 10 times higher risk of food allergy with low vitamin D
  • People living in cities or having dark skins generally have low vit D and more allergies
  • There is Overwhelming Evidence that vitamin D reduces allergies
          (More Allergy info below)

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Food Allergy 5X more likely if low vitamin D – Oct 2014

The link between serum vitamin D level, sensitization to food allergens, and the severity of atopic dermatitis in infancy.
J Pediatr. 2014 Oct;165(4):849-54.e1. doi: 10.1016/j.jpeds.2014.06.058. Epub 2014 Aug 6.
Baek JH1, Shin YH1, Chung IH1, Kim HJ1, Yoo EG1, Yoon JW2, Jee HM1, Chang YE3, Han MY4.
1Department of Pediatrics, CHA University School of Medicine, Seongnam, Korea.
2Myongji General Hospital, Goyang, Korea.
3Department of Food and Nutrition Services, CHA Bundang Medical Center, Seongnam, Korea.
4Department of Pediatrics, CHA University School of Medicine, Seongnam, Korea. Electronic address: drmesh at gmail.com.

VitaminDWiki

Vitamin D deficiency definition varies
This article is similar to many countries: < 20 ng
The lower the vitamin D level, the more allergies each child had

OBJECTIVE: To investigate the association between serum vitamin D levels, sensitization to food allergens, and the severity of atopic dermatitis in infants.

STUDY DESIGN: We investigated serum 25-hydroxyvitamin D (25[OH]D) and specific immunoglobulin E levels to common or suspected food allergens in 226 infants with atopic dermatitis or food allergy. The severity of atopic dermatitis by the Scoring Atopic Dermatitis index and amount of vitamin D intake was measured in subcohort children. Sensitization to food allergen was categorized by the number (non-, mono-, and poly-) of sensitized allergens and the degree (undetected-, low-, and high-level) of sensitization.

RESULTS: Significant differences in 25(OH)D levels were found between groups on number (P = .006) and degree (P = .005) of food sensitization. The polysensitization group had significantly lower levels of 25(OH)D than the nonsensitization (P = .001) and monosensitization (P = .023) group. High-level sensitization group had significantly lower 25(OH)D levels compared with undetected (P = .005) and low-level (P = .009) sensitization group. Vitamin D deficiency increased the risk of

  • sensitization to food allergens (OR 5.0; 95% CI 1.8-14.1), especially to
  • milk (OR 10.4; 95% CI 3.3-32.7) and
  • wheat (OR 4.2; 95% CI 1.1-15.8).

In addition, the Scoring Atopic Dermatitis index was independently related to 25(OH)D levels after adjusting for the level of sensitization (adjusted R(2) = 0.112, P = .031).

CONCLUSIONS: Our results suggest that vitamin D deficiency increases the risk of sensitization to food allergens and that atopic dermatitis may be more severe in infants with vitamin D deficiency.


Image Image

Copyright © 2014 Elsevier Inc. All rights reserved.

PMID: 25108543
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10X more likely to have multiple food allergies if low vitamin D - Sept 2013

1 page item had the following results
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Vitamin D levels and food and environmental allergies in the United States - May 2011

Results from the National Health and Nutrition Examination Survey 2005-2006
The Journal of Allergy and Clinical Immunology, Volume 127, Issue 5 , Pages 1195-1202, May 2011
Shimi Sharief, MD; Sunit Jariwala, MD; Juhi Kumar, MD, MPH; Paul Muntner, PhD; Michal L. Melamed, MD,

Background: Previous research supports a possible link between low vitamin D levels and atopic disease.
However, the association between low vitamin D levels and total and allergen-specific IgE levels has not been studied.

Objective: We sought to test the association between serum 25-hydroxyvitamin D (25[OH]D) deficiency (<15 ng/mL) and insufficiency (15-29 ng/mL) and allergic sensitization measured by serum IgE levels in a US nationally representative sample of 3136 children and adolescents and 3454 adults in the National Health and Nutrition Examination Survey 2005-2006.

Methods: The association of 25(OH)D deficiency with 17 different allergens was assessed after adjustment for potential confounders, including age; sex; race/ethnicity; obesity, low socioeconomic status; frequency of milk intake; daily hours spent watching television, playing videogames, or using a computer; serum cotinine levels; and vitamin D supplement use.

Results: In children and adolescents allergic sensitization to 11 of 17 allergens was more common in those with 25(OH)D deficiency. Compared with sufficient vitamin D levels of greater than 30 ng/mL, after multivariate adjustment, 25(OH)D levels of less than 15 ng/mL were associated with

  • peanut (odds ratio [OR], 2.39; 95% CI, 1.29-4.45),
  • ragweed (OR, 1.83; 95% CI, 1.20-2.80), and
  • oak (OR, 4.75; 95% CI, 1.53-4.94) allergies (P < .01 for all).

Eight other allergens were associated with 25(OH)D deficiency, with P values of less than .05 but greater than .01.
There were no consistent associations seen between 25(OH)D levels and allergic sensitization in adults.

Conclusion: Vitamin D deficiency is associated with higher levels of IgE sensitization in children and adolescents.
Further research is needed to confirm these findings.


Gut microbiota, probiotics, and vitamin D - May 2011

:next term Interrelated exposures influencing allergy, asthma, and obesity?
Journal of Allergy and Clinical Immunology
Volume 127, Issue 5, May 2011, Pages 1087-1094; doi:10.1016/j.jaci.2011.02.015
Ngoc P. Ly MD, MPHa, Corresponding Author Contact Information, E-mail The Corresponding Author, Augusto Litonjua MD, MPHb, Diane R. Gold MD, MPHb and Juan C. Celedón MD, DrPHc
a Division of Pediatric Pulmonary Medicine, Department of Pediatrics, University of California San Francisco, San Francisco, Calif
b Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass
c Division of Pediatric Pulmonary Medicine, Allergy and Immunology, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pa

Current evidence supports a role for gut colonization in promoting and maintaining a balanced immune response in early life. An altered or less diverse gut microbiota composition has been associated with atopic diseases, obesity, or both. Moreover, certain gut microbial strains have been shown to inhibit or attenuate immune responses associated with chronic inflammation in experimental models. However, there has been no fully adequate longitudinal study of the relation between the neonatal gut microbiota and the development of allergic diseases (eg, atopic asthma) and obesity. The emergence of promising experimental studies has led to several clinical trials of probiotics (live bacteria given orally that allow for intestinal colonization) in human subjects. Probiotic trials thus far have failed to show a consistent preventive or therapeutic effect on asthma or obesity. Previous trials of probiotics have been limited by small sample size, short duration of follow-up, or lack of state-of-the art analyses of the gut microbiota. Finally, there is emerging evidence that the vitamin D pathway might be important in gut homeostasis and in signaling between the microbiota and the host. Given the complexity of the gut micriobiota, additional research is needed before we can confidently establish whether its manipulation in early life can prevent or treat asthma, obesity, or both.

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Food allergies in children 40 % more likely in urban areas (which have less vitamin D) – Sept 2012


Geographic Variability of Childhood Food Allergy in the United States
CLIN PEDIATR September 2012 vol. 51 no. 9 856-861
Ruchi S. Gupta, MD, MPH1,2; Elizabeth E. Springston, BA1; Bridget Smith, PhD3,4; Manoj R. Warrier, MD5,6; Jacqueline Pongracic, MD1,2; Jane L. Holl, MD, MPH1
1 Northwestern University Feinberg School of Medicine, Chicago, IL, USA
2 Children’s Memorial Hospital, Chicago, IL, USA
3 Loyola Stritch School of Medicine, Maywood, IL, USA
4 Edward Hines Jr VA Hospital, Hines, IL, USA
5 Saint Louis University School of Medicine, Saint Louis, MO, USA
6 Allergy, Asthma and Sinus Care Center, Saint Louis, MO, USA
Ruchi S. Gupta, Children’s Memorial Hospital, 2300 Children’s Plaza, Box 157, Chicago, IL 60640, USA Email: rugupta at childrensmemorial.org

Objective The aim of this study was to describe the distribution of childhood food allergy in the United States.

Methods A randomized survey was administered electronically from June 2009 to February 2010 to adults in US households with at least 1 child younger than 18 years. Data were analyzed as weighted proportions to estimate prevalence and severity of food allergy by geographic location. Multiple logistic regression models were constructed to estimate the association between geographic location and food allergy.

Results Data were analyzed for 38 465 children. Increasing population density corresponded with increasing prevalence, from 6.2% in rural areas (95% confidence interval [CI] = 5.6-6.8) to 9.8% in urban centers (95% CI = 8.6-11.0).

Odds of food allergy were graded, with odds in urban versus rural areas highest (odds ratio OR = 1.7, 95% CI = 1.5-2.0), followed by metropolitan versus rural areas (OR = 1.4, 95% CI = 1.2-1.5), and so on. Significance remained after adjusting for race/ethnicity, gender, age, household income, and latitude.

Conclusions An association between urban/rural status and food allergy prevalence was observed.


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Allergy - Overview        

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7821 Food allergy 2.2X MORE likely if high vitamin D - 2016.pdf PDF 2016 admin 2017-03-11 02:50 231.64 Kb 34
7741 WAO Allergy.pdf PDF 2016 admin 2017-02-20 22:50 562.05 Kb 61
4962 Food allergy.pdf PDF 2014 admin 2015-01-22 14:21 606.87 Kb 946
4961 Food allergy appendix.jpg admin 2015-01-22 14:19 20.47 Kb 4201
4960 Food F4B.jpg admin 2015-01-22 14:19 22.58 Kb 4085
3108 Allergy association.jpg 2013 admin 2013-10-08 13:22 44.74 Kb 5714
1215 Gut microbiota, probiotic-2011.pdf gut PDF admin 2012-04-06 03:12 148.37 Kb 3389
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