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Overview Kidney Stones and vitamin D

Vitamin K2 might reduce incidence of Kidney Stones


Magnesium appears to both prevent and treat Kidney stones > 900,000 hits Jan 2013


Hypothesis: Elevated serum vitamin D was a sign of the body healing and ejecting a kidney stone


Summer Heat & Kidney Stones - Why Summer Is Kidney Stone Season
Drinking more of the right fluids can help you avoid summer kidney stone flareups

http://www.associatedcontent.com/article/1763080/seasonal_kidney_stones_recognizing.html

http://www.healthhype.com/kidney-stone-causes-and-risk-factors.html
Seasonal episodes of kidney stones may be related to summer or heat waves as the body lose fluid through perspiration (sweating) and urine...

http://www.ehow.com/how_2190538_prevent-kidney-stones-summer.html
How to Prevent Kidney Stones in Summer. Kidney stones form when the body doesn't properly flush out minerals and chemicals ingested such as calcium, ...

http://www.springerlink.com/content/vn7376542v9r40q6/
Seasonal variations in urinary excretion of calcium and magnesium ... by J G?uszek - 1978
probable that the lack of seasonal changes in calciuria may be connected first ... In the summer, patients with renal stones and healthy subjects show a ...

http://www.dailymail.co.uk/health/article-1190146/How-summer-affects-health--good-ill.html
How summer affects your health... for good or ill |5 Jun 2009 ... KIDNEY STONES (improves). Summer is known as 'kidney stone season' by medics because they see twice as many of them as in winter. ...

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1731261/
Why oral calcium supplements may reduce renal stone disease ...by C Williams - 2001 -
Seasonal variations in the composition of urine in relation to calcium stone-formation. ... A common molecular basis for three inherited kidney stone diseases. ....

http://www.vitamindcouncil.org/newsletter/2006-aug.shtml
Newsletter by Dr. Cannell: Does vitamin D cause kidney stones?

  • Kidney stones are just like influenza. Scientists have not seen the forest for the trees yet.
  • In winter we get more influenza due to vitamin D deficiency.
  • In summer we eject kidney stones due to elevated serum levels of vitamin D healing the kidney.

Grassroots web page on Kidney Stones

Dr. Heaney's Comments:

  • Kidney stones are of many types and have many causes.
  • The most common types in the US are calcium oxalate stones.
  • The stone should be analyzed so as to determine the approach to treatment.
  • Whatever the stone type, stone formers have a defect in kidney production of a solution stabilizer, normally secreted into the urine.
    • This keeps the commonly supersaturated urine from forming precipitates (which then aggregate into stones).
  • There are two basic approaches indicated in most cases.
    • One is to drink large amounts of water each day to keep the urine diluted
    • The second is to reduce the urine content of components that form precipitates. For example, if the stone is a urate stone, medicines will be prescribed that reduce the body's production of uric acid. Or if the stone is calcium oxalate, large quantities of calcium should be ingested to block absorption of oxalic acid from the intestinal contents, thereby reducing the amount of oxalate that will have to be excreted through the kidneys. While high calcium intake sounds counter-intuitive, there is a solid scientific base for the recommendation, and persuasive clinical trial data showing that it works. Placing patients on low calcium diets will actually double the risk of having a second stone.
  • There are several other approaches that might be taken, but the foregoing hit the main points. It's important to remember that the basic defect (absence of a solution stabilizer) persists, so whatever strategy works will have to become permanent.
  • Vitamin D, in doses producing desirable serum levels of 25(OH)D (40-60 ng/ml or 100-150 nmol/L), does not adversely affect any of the components of this system

No extra Kidney stones when vitamin D2 added – May 2012

Effect of Vitamin D Repletion on Urinary Calcium Excretion among Kidney Stone Formers
CJASN May 2012 vol. 7 no. 5 829-834
David E. Leaf*,†, Ruslan Korets‡, Eric N. Taylor§, Jie Tang?, John R. Asplin¶, David S. Goldfarb**, Mantu Gupta‡, Gary C. Curhan†
Departments of *Medicine and
‡Urology, Columbia University, New York, New York;
†Division of Renal Medicine, Brigham and Women’s Hospital, Boston, Massachusetts;
§Division of Nephrology and Transplantation, Maine Medical Center, Portland, Maine;
?Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado;
¶Litholink Corporation, Chicago, Illinois; and
**Nephrology Section, New York Harbor VA Healthcare System, New York, New York
Correspondence:
Dr. David E. Leaf, Renal Division, Brigham and Women’s Hospital, 75 Francis Street, Boston MA 02115. Email: DELEAF at partners.org
M.G. and G.C.C. contributed equally to this work.

Background and objectives Despite the important role of vitamin D in maintaining bone health, many clinicians are reluctant to treat vitamin D deficiency in kidney stone formers because of the theoretical risk of increasing urinary calcium excretion. This study examined the effect of vitamin D repletion on urinary calcium excretion among stone formers.

Design, setting, participants, & measurements Participants (n=29) were recruited from urology clinics affiliated with New York Presbyterian Hospital. Enrollment criteria included a history of nephrolithiasis, urinary calcium excretion between 150 and 400 mg/d, and a serum 25-hydroxyvitamin D level <30 ng/ml. Participants were given oral ergocalciferol (50,000 IU/wk) for 8 weeks. Serum and 24-hour urine tests were repeated after 8 weeks.

Results Levels of 25-hydroxyvitamin D increased significantly after vitamin D repletion (17±6 and 35±10 ng/ml, P<0.001), but mean 24-hour urinary calcium excretion did not change (257±54 and 255±88 mg/d at baseline and follow-up, respectively, P=0.91). However, 11 participants had an increase in urinary calcium excretion ?20 mg/d; these participants also had an increase in urine sodium excretion, likely reflecting dietary variability. No participant experienced adverse effects from vitamin D, including hypercalcemia.

Conclusions Among stone formers with vitamin D deficiency, a limited course of vitamin D repletion does not seem to increase mean urinary calcium excretion, although a subset of individuals may have an increase. These data suggest that vitamin D therapy, if indicated, should not be withheld solely on the basis of stone disease, but 24-hour urinary calcium excretion should be monitored after repletion.

Received November 6, 2011; Accepted February 18, 2012.


See also VitaminDWiki

released Nov 30, 2010

2 studies showing increased Kidney stones with LOW vitamin D - Vitamin D council May 2016

Does vitamin D cause kidney stones?

  • Girón-Prieto MS, et al. Analysis of vitamin D deficiency in calcium stone-forming patients. Int Urol Nephrol. 2016 Apr 19. [Epub ahead of print]
  • Ticinesi A, et al. Idiopathic Calcium Nephrolithiasis and Hypovitaminosis D: A Case-control Study. Urology. 2016 Jan;87:40-5.

Kidney stones (Calcium) associated with lower vitamin D this time – April 2016 VitaminDWiki report on one of them

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