Overview Cardiovascular and vitamin D

Did you know? (from VitaminDWiki)

Many studies show that cardiovascular problems are treated & prevented by Vitamin D
  As with many other health problems:
  More Vitamin D is needed to treat than to prevent
  Omega-3, Magnesium, and Vitamin K2 also probably also help
      (More Cardiovascular info below this box)

Learn how Vitamin D is essential for good health
  Watch a 5 minute video "Does Less Sun Mean more Disease?"
  Browse for other Health Problems and D in left column or here
  see also Supplementing for D and More in the menu at the top of very page

See also VitaminDWiki: Cardiovascular - general

Image Image

Pages listed in BOTH the categories Vitamin K and Cardiovascular

Pages listed in BOTH the categories MORTALITY and Cardiovascular

All items in Mortality and vitamin D (not just Cardio) 137 items

See also in VitaminDWiki HYPERTENSION

Pages listed in BOTH the categories Hypertension and Cardiovascular

See also in VitaminDWiki STROKES

Items in BOTH of the categories Cardiovascular and Stroke:

See also in VitaminDWiki Metabolic Syndrome

Note Metabolic Syndrome = a combination of medical disorders which together increase the risk of developing cardiovascular disease and diabetes.

Items in BOTH of the categories Cardiovascular and Metabolic Syndrome:

See also web


MAYO Clinic April 2012: Pathways from vitamin D Deficiency to CVD

see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=1422

The effect of vitamin D status on risk factors for cardiovascular disease Nature 2013

$4 to rent the PDF - but the following chart from the study is on Google images

Random controlled trial found NO HEART FAILURE BENEFIT with 50,000 IU weekly - Feb 2013 - strange

A randomized controlled trial of high dose vitamin D3 in patients with heart failure.
JACC Heart Fail. 2013 Feb;1(1):84-90. doi: 10.1016/j.jchf.2012.11.003.
Boxer RS1, Kenny AM2, Schmotzer BJ3, Vest M4, Fiutem JJ5, Piña IL6.

OBJECTIVE: To investigate the effect of Vitamin D3 on physical performance in patients with HF.

BACKGROUND: HF is associated with functional decline and frailty. Vitamin D deficiency is associated with loss of muscle strength and poor outcomes in patients with HF.

METHODS: Sixty-four patients participated in a 6-month parallel design double blind RCT to test the hypothesis that oral vitamin D3 would improve physical performance. Vitamin D3 50,000 IU or placebo was given weekly; all received daily calcium. Patients were included regardless of EF and 25OHD ≤ 37.5 ng/ml. The primary outcome was peak VO2, and secondary outcomes were the 6MW, TGUG and knee isokinetic muscle strength. Between group comparisons were made using ANCOVA models that adjust for baseline measures.

RESULTS: Patients were age 65.9 ± 10.4 years old, 48% women, 64% African American, EF 37.6±13.9, 36% NYHA III, the remainder NYHA II.
At baseline the vitamin D group 25OHD was 19.1 ± 9.3 ng/ml and increased to 61.7 ± 20.3 ng/ml; in the placebo group baseline 25OHD was 17.8 ± 9.0 ng/ml and decreased to 17.4 ± 9.8 ng/ml at 6 months (between groups p<0.001).
There was no significant change from baseline to 6 months in peak VO2, 6MW, TGUG or isokinetic muscle strength.

CONCLUSIONS: Vitamin D3 did not improve physical performance for patients with HF despite a robust increase in serum 25OHD.
Vitamin D repletion in patients with HF should conform to standard adult guidelines for vitamin D supplementation.

PMID: 24614995
 Download the PDF from VitaminDWiki.

Strange - seems like the study did things correctly.Good amount of vitamin D, trial lasted long enough, vitamin D levels were raised high enough. Yet no benefit.

INTERVENTION Clinical Trials for (heart OR cardiovascular) and "vitamin D" 265 as of Jan 2017

  • Intervention = give vitamin D and see what happens usually testing vitamin D vs placebo
  • The majority of these intervention trials are for TREATMENT, rather than prevention
  • Vitamin D and cardiovascular disease preventiom May 2016
    Large Ongoing Random Controlled CVD trials
    No apparent attempt to trial those with low levels of vitamin D,
    No Magnesium added,
    No Omega-3 added,
    Not much vitamin D used - especially since statins used with CVD reduce the vitamin D
    No Vitamin K2 to stop Calcium increased by Vitamin D from coating the arteries


76 proofs that Vitamin D works (as of Dec 2016)

Proof that Vitamin D Works has the following Cardio related proofs

Health Problem Treat
   click for details
RCT = Random Controlled Trial
   * = link to additional RCT
CT = Clinical Trial
HypertensionT 149 to 142 mm Hg RCT*  *, 2400 IU.  100,000 IU* 1
Cardiovascular after attack T 32 % fewer deaths CT 1000 IU2
Diabetes T2T 62 % RCT* *, CRP reduction, 4000 IU 4
Congestive Heart Failure T 90 % RCT, 1000 IU infants (also: Adults, not RCT) 27
After Heart Attack T __+6% ejection fraction RCT, 800,000 IU one time34

See also: Omega-3

Items in BOTH of the categories Cardiovascular and Omega-3:

Items in BOTH of the categories Cardiovascular and Magnesium:

Short url = http://bit.ly/Zczfrw

Created by Editor. Last Modification: Friday March 17, 2017 17:37:23 UTC by admin. (Version 136)

Overview Cardiovascular and vitamin D        

34242 visitors, last modified 17 Mar, 2017, URL:

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Attached files

ID Name Comment Uploaded Size Downloads
6793 CVD RCT.jpg admin 15 Jun, 2016 21:46 64.42 Kb 901
4999 Heart Failure.pdf PDF 2013 admin 01 Feb, 2015 20:34 324.72 Kb 838
4822 Cardio Nature 2013.jpg admin 04 Jan, 2015 15:34 83.96 Kb 2689
3642 Cardiovascular - Feb 2014.pdf PDF 2014 admin 22 Feb, 2014 12:45 953.07 Kb 1411
2869 Cardiac 2012.pdf PDF admin 04 Aug, 2013 12:28 738.94 Kb 3005
2366 Afib Mayo.pdf PDF admin 14 Apr, 2013 14:55 397.95 Kb 1998
1322 CVD 2X.jpg admin 12 May, 2012 11:37 46.99 Kb 4161
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