Reasons to associate concussion with low vitamin D
- Those people having concussions have lower vitamin D levels
- Increase in number of concussions as vitamin D levels have dropped
- Giving vitamin D (and other supplements) shortens recovery time from concussions
- Giving vitamin D resulted in fewer concussions (football players)
Researchers tie Gulf War illness to brain damage USA Today March 2013
- Using fMRI machines, the Georgetown University researchers were able to see anomalies in the bundle of nerve fibers that interpret pain signals in the brain in 31 Gulf War veterans. The research will be published Wednesday in PLOS ONE journal.
CAUTION: The FMRI magnetic fields MAY substantially reduce the vitamin D levels - Update May 2013
- CLICK HERE for the article and PDF
- CBS interviewed a Major who would have preferred losing a limb to the TBI, Was almost suicidal
- lots of confusion in the military between TBI and post traumaic stress
- Long term cognitive problems if get 2nd TBI before the first one heals
- A new brain facility was made (with donated money) – which had far higher resolution imaging
- They were able to find abnormalities in 1/3 of people who had not been previously detected
- But the facility can only process about 20 people per month – vs 10,000 are suspected as still having TBI
- Bottom line – They still have no way of treating brain damage
A New Way to Care for Young Brains New York Times May 2013
Highlights of a long interesting article on the concerns by parents of concussions in school sports
- In the last three years, dozens of youth concussion clinics have opened in nearly 35 states
- Boston Children’s Hospital, sports concussion clinic business increased 15X in 5 years
- 43 states passing laws requiring school-age athletes who have sustained a concussion to have written authorization from a medical professional
- 90 % of concussions are resolved in a month, if not sooner.
- about 4,000,000 concussions diagnosed annually in America
- There is no wall chart or medical textbook that says just how much rest or inactivity is needed
- In the worst case, known as second-impact syndrome, it can be a fatal combination.
- One of the most commonly known treatment protocols is cognitive rest,
- Tests, which measure reaction time, learning and memory skills, and how quickly a person thinks and solves problems, are stored at the beginning of the season.
- “Concussion clinics might be seen as a loss leader for the halo effect they bring the institution,”
- Emergency room visits by children and adolescents with brain injuries have increased by more than 60 % in the past eight years,
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Three Hypothesis by VitaminDWiki:
- Less vitamin D ==> thinner bones ==> More skull fractures = TBI
- Less vitamin D ==> less able to undergo trauma (such as a concussion)
Note: Traumas consume vitamin D, so a series of traumas will result in very low vitamin D levels
- Less vitamin D ==> less muscle and slower muscle response ==> fall more
Wonder if the increase in TBI is associated with the decrease in vitamin D
Note that seniors have more falls when they have lower vitamin D.
- There was an increase in TBI-related emergency department visits (14.4%) and hospitalizations (19.5%) from 2002 to 2006.
- There was a 62% increase in fall-related TBI seen in emergency departments among children aged 14 years and younger from 2002 to 2006.
- There was an increase in fall-related TBI among adults aged 65 and older;
- 46% increase in emergency department visits,
- 34% increase in hospitalizations, and
- 27% increase in TBI-related deaths from 2002 to 2006.
Misc TBI charts
Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease.
Front Neuroendocrinol. 2009 Jul;30(2):158-72. Epub 2009 Apr 24; Cekic M, Sayeed I, Stein DG.
Department of Emergency Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
More than two decades of pre-clinical research and two recent clinical trials have shown that progesterone (PROG) and its metabolites exert beneficial effects after traumatic brain injury (TBI) through a number of metabolic and physiological pathways that can reduce damage in many different tissues and organ systems. Emerging data on 1,25-dihydroxyvitamin D(3) (VDH), itself a steroid hormone, have begun to provide evidence that, like PROG, it too is neuroprotective, although some of its actions may involve different pathways. Both agents have high safety profiles, act on many different injury and pathological mechanisms, and are clinically relevant, easy to administer, and inexpensive. Furthermore, vitamin D deficiency is prevalent in a large segment of the population, especially the elderly and institutionalized, and can significantly affect recovery after CNS injury. The combination of PROG and VDH in pre-clinical and clinical studies is a novel and compelling approach to TBI treatment.
PMID: 19394357 CLICK HERE for PDF
Traumatic brain injury and aging: is a combination of progesterone and vitamin D hormone a simple solution to a complex problem?
Neurotherapeutics. 2010 Jan;7(1):81-90; Cekic M, Stein DG; Emory University School of Medicine, Department of Emergency Medicine, Atlanta, Georgia 30322, USA.
Although progress is being made in the development of new clinical treatments for traumatic brain injury (TBI), little is known about whether such treatments are effective in older patients, in whom frailty, prior medical conditions, altered metabolism, and changing sensitivity to medications all can affect outcomes following a brain injury. In this review we consider TBI to be a complex, highly variable, and systemic disorder that may require a new pharmacotherapeutic approach, one using combinations or cocktails of drugs to treat the many components of the injury cascade. We review some recent research on the role of vitamin D hormone and vitamin D deficiency in older subjects, and on the interactions of these factors with progesterone, the only treatment for TBI that has shown clinical effectiveness. Progesterone is now in phase III multicenter trial testing in the United States. We also discuss some of the potential mechanisms and pathways through which the combination of hormones may work, singly and in synergy, to enhance survival and recovery after TBI.
PMID: 20129500 PDF is attached at the bottom of this page
See also VitaminDWiki
- Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012 Iran
- If less than 20 ng then 2X more likely to be fatigued after brain injury - April 2010
- Reduced vitamin D and BMD and Neurological Conditions – April 2011
- Overview: Fibromyalgia or Chronic Fatigue and vitamin D
- All items in Surgery, trauma and vitamin D
- most traumas use up a lot of vitamin D
- 2,500 years ago Herodotus noticed that more sunshine (vitamin D) resulted in stronger skulls
- Traumatic Brain Injury reduces vitamin D which causes chronic fatigue
- Fat soluable vitamins decrease quickly after trauma
- Overview Sports and Vitamin D
faster muscles, fewer injuries, etc.
- More muscle response when have adequate vitamin D - perhaps less able to avoid a concussion if have low vitamin D
- Parkinson disease 2X more likely after brain injury – which usually reduces vitamin D – Nov 2012
- High school sports did extremely well and eliminated injuries and concussions with Vitamin D Matthews
- A Concussion-Free Football Season: How one High School beat the odds - July 2012 Matthews
- Surgeon on a mission to promote vitamin D - Dec 2012 Matthews
- PDF attached to the bottom of this page Matthews Dec 2012 - brifly mentions use of Omega-3 with the Vitamin D, along with the other members of the team
- Vitamin D Helps Atlanta High School Athletes - Feb 2012 Matthews
- Magnesium may be an important way to treat brain trauma
- Brain lesions might be associated with vitamin D deficiency – March 2012
- Traumatic brain injury treated by Vitamin D Progesterone Omega-3 and glutamine – May 2013 Matthews
- Traumatic Brain Injury in military - vitamin D - 2014
See also web
- Progesterone and vitamin D combination therapy modulates inflammatory response after traumatic brain injury June 2015
The combination is needed. 40 IU of vitamin d/kg of weight of rat. Publisher wants $52 for the PDF
- RCT: Vitamin D levels and traumatic brain injury Vitamin D Council Dec 2012
35% made good recovery with progesterone and vitamin D, vs only 15% in placebo
10 % died in the progesterone + vitamin D group vs 40% in the placebo group
- Obama Not Sure He'd Allow a Son to Play Football USA today was one of the many that posted the Associated Press News item
You read some of these stories about college players who undergo some of these same problems with concussions and so forth and then have nothing to fall back on. That's something that I'd like to see the NCAA think about.
Quote from interview to be published in New Republic. Feb 11, 2013
- Brain Injury Infographic a portion of which is below
- Cycling Is the Top Sport for Head Injuries New York Times, June 2013
bicycling 86,000; Football 47,000; baseball 38,394: 2009
90 % of US bicyclists killed were not wearing helmets. A majority were middle-aged men.
- Progesterone and low-dose vitamin D hormone treatment enhances sparing of memory following traumatic brain injury. April 2012
Atlanta Georgia (location of Dr. Matthews), full text on-line, rat study
- Nutrition and Traumatic Brain Injury: Improving Acute and Subacute Health Outcomes in Military Personnel (2011)
- pages 283-290 on Vitamin D
- Vitamin D Deficiency Associated With Chronic Fatigue in Brain Injured Patients Science Daily April 2010
- Chronic fatigue link to vitamin D deficiency May 2010
- Self-Administered Light Therapy May Improve Cognitive Function After Traumatic Brain Injury no vitamin D
- this is one a great many items on the web from the same source
- Large CDC study of TBI 2007 is attached at bottom of this page
- N.F.L. Agrees to Settle Concussion Suit for $765 Million NYT Aug 2013
settle a lawsuit brought by more than 4,500 players and their families,
chronic traumatic encephalopathy, or C.T.E., a degenerative brain disease similar to Alzheimer’s disease. It is believed to be caused only by repeated head trauma.
- Chart: Trauma Hospitals Fail to Screen for Civilian PTSD ProPublica March 2014
Majority of Hospitals surveyed did not screen for PTSD - often just too expensive. No mention of vitamin D
- For catchers, concussion dangers all too real USA Today Sept 2013
18 in 2013 (9 were off of catchers masks), 13 in 2012, 11 in 2011
- Nutritional treatment for traumatic brain injury March 2014
The purpose of this review is to highlight four promising nutritional intervention options that have been identified, omega-3, zinc, vitamin D and glutamine,
- Traumatic Brain Injury has increased in military by 170 %
- Brain Changes in College Football Players Raise New Concerns NY Times May 2014
Compared the size of hypocampus of 3 college groups data from JAMA article
Never played football = normal hypocampus
Football players who never had concussion = 16% smaller than normal
Football players who had 1 or more concussions = 25% smaller than normal
- Nutritional treatment for acute and chronic traumatic brain injury patients May 2014
Human studies: omega 3 fats, vitamin D, NAcetylcysteine, branched chain amino acids, and zinc
Animal studies: alphalipoic acid, magnesium, taurine, coenzyme Q10, and many phytonutrients (such as resveratrol)
- Finding a link between genes and brain injury: Are some people predisposed to trauma? Washington Post May 2014
3 variations in APOE gene ==> 10X as likely to report a concussion and more than 8X as likely to have suffered brain injury as a result.
- Perhaps Ali's Parkenson's Disease was due to chronic traumatic encephalopathy Slate June 2016
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