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Women with more than minimum vitamin D were 3.4 X more likely to achieve pregnancy and 1.6 X more likely to have live births – June 2017

Association of vitamin D intake and serum levels with fertility: results from the Lifestyle and Fertility Study

Fertility and Sterility, Available online 16 June 2017
June L. Fung, Ph.D.a, , , Terryl J. Hartman, Ph.D.b, Rosemary L. Schleicher, Ph.D.c, Marlene B. Goldman, Sc.D.a, d
a Department of Obstetrics and Gynecology, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire
b Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia
c Division of Laboratory Sciences, National Center for Environmental Health, Centers for ,Disease Control and Prevention, Atlanta, Georgia
d Community and Family Medicine, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire


Objective: To evaluate the role of vitamin D intake and serum levels on conception of clinical pregnancy and live birth.

Design: Prospective cohort study.

Setting: Academic medical centers.

Patient(s): Healthy, nulliparous women, age 18–39 years, and their male partners.

Intervention(s): None.

Main Outcome Measure(s): Clinical pregnancy and live birth were compared between those who did or did not meet the vitamin D estimated average requirement (EAR) intake (10 μg/d) and with serum 25-hydroxyvitamin D (25(OH)D) considered at risk for inadequacy or deficiency (<50 nmol/L) or sufficient (≥50 nmol/L).

Result(s): Among 132 women, 37.1% did not meet the vitamin D EAR and 13.9% had serum levels at risk for inadequacy or deficiency.
Clinical pregnancies were significantly higher among women who met the vitamin D EAR (67.5% vs. 49.0%) and with sufficient serum 25(OH)D (64.3% vs. 38.9%) compared with those who did not.
Live births were higher among those who met the vitamin D EAR (59.0% vs. 40.0%). The adjusted odds ratio (AOR) of conceiving a clinical pregnancy was significantly higher among those who met the EAR (AOR = 2.26; 95% confidence interval [CI], 1.05–4.86) and had sufficient serum 25(OH)D (AOR = 3.37; 95% CI, 1.06–10.70). The associations were not significant after controlling for selected nutrients and dietary quality.

Conclusion(s): Women with vitamin D intake below EAR and serum 25(OH)D levels at risk for inadequacy or deficiency may be less likely to conceive and might benefit from increased vitamin D intake to achieve adequacy.

Clinical Trial Registration Number: NCT00642590.

Available online 16 June 2017 https://doi.org/10.1016/j.fertnstert.2017.05.037 Purchase $35.95

Created by admin. Last Modification: Saturday August 26, 2017 15:19:34 UTC by admin. (Version 6)
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