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Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017

Efficacy of adding nutritional supplements in unipolar depression: A systematic review and meta-analysis

European Neuropsychopharmacology, online 5 October 2017
Cora Schefft a, Laura L.Kilarski b. Tom Bschor c, Stephan Köhler
https://doi.org/10.1016/j.euroneuro.2017.07.004

See also VitaminDWiki

Vitamin D and Omega-3 have decreased a lot recent decades

Zinc and Vitamin D category has 16 items

20 Most-visited pages in Depression category in VitaminDWiki

Id Page Hits Last modification Creator Categories
3315 Hypothesis: Some Mental Illness could be treated or prevented with vitamin D 19849
24 Jul, 2016 12:48
admin Depression
Treatment by Vitamin D
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7681 Depression 15535
17 Nov, 2017 20:31
admin Depression
Category
5777 Suicide associated with low vitamin D 12497
11 Oct, 2017 14:44
admin Depression
1052 Hypothesis - Reduce insomnia with vitamin D 11431
13 Oct, 2010 21:55
admin Depression
5764 Just 1500 IU of Vitamin D significantly helps Prozac – RCT March 2013 10987
14 Jun, 2016 02:26
admin Depression
Intervention
537 Prisoners have very low vitamin D and get TB, influenza, and depression 9189
06 Jan, 2016 12:32
admin Deficiency of Vitamin D
Tuberculosis
Immunity
Depression
Shut-in
4658 First episode psychosis associated with a 33 percent lower vitamin D in 3 races – Sept 2013 9175
09 Dec, 2017 16:17
admin Depression
5252 Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014 8597
09 Oct, 2016 08:35
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5082 Children with mental disorders have somewhat less vitamin D levels (graph) Jan 2014 8572
23 Feb, 2014 12:45
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Cognitive
4028 Fewest Google searches for Mental Health when there is lots of vitamin D from the sun – May 2013 8539
29 Apr, 2013 20:21
admin Depression
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Cognitive
3608 Suicide 2X more likely with low vitamin D (in military) – Jan 2013 8126
15 Aug, 2015 15:50
admin Depression
4757 Reduced depression with single 300,000 IU injection of vitamin D – RCT June 2013 7031
18 Sep, 2017 17:15
admin Depression
Intervention
Top news
Injection
2439 Teens no longer depressed after vitamin D raised to 36 ng – Feb 2012 6997
18 Aug, 2012 03:09
admin Depression
Youth
317 Chicago Sun Times on vitamin D: Depression, chest pain, fibromyalgia, Holick, 3000 IU without test - May 2010 6882
15 Jul, 2015 17:04
admin Deficiency of Vitamin D
Diabetes
Depression
5000 44X increase in Bipolar Disorder in youth in a decade – Sept 2007 6768
11 May, 2017 12:36
admin Depression
5731 Your health has a symbiotic relationship with 100 Trillion Bacteria – Mercola Aug 2014 6707
28 Aug, 2014 11:39
admin Depression
Antibiotics, probiotics
5075 Serotonin regulated by Vitamin D – part 1 autism – Feb 2014 6133
26 Aug, 2017 13:16
admin Depression
Autism
3066 Major depression associated with low vitamin D and low bone density – July 2012 6042
24 Jan, 2015 03:36
admin Bone - Health
Depression
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838 An Exploratory Study of Postpartum Depression and Vitamin D - May 2010 5940
12 Sep, 2014 13:14
admin Pregnancy
Depression
Women
181 Table of outcomes for seniors vs vitamin D level 5725
21 Dec, 2014 16:38
admin Seniors
Cardiovascular
Kidney
Diabetes
Mortality and D
Depression

Pages listed in BOTH the categories Depression and Omega-3


In this article, we aimed to assess the efficacy of adjunctive administration of nutritional supplements to antidepressants by means of a systematic review and meta-analysis. The supplements included were inositol, vitamin D, folic acid, vitamin B12, S-adenosyl-L-methionine (SAMe), omega-3 polyunsaturated fatty acids (n-3 PUFA) and zinc.

A structured database search (MEDLINE, EBSCO, CENTRAL, Web of Science) was performed using terms for the respective substances in conjunction with terms for depression and the mode of treatment (“add-on” OR "adjunctive" OR "augmentation"). Meta-analyses, randomized controlled trials (RCTs) and non-randomized comparative studies that investigated the supplements as an add-on in the treatment of clinically diagnosed MDD were included. Agents had to be added to an existing antidepressant regime (augmentation) or started simultaneously with the antidepressant (acceleration). For n-3 PUFAs, folic acid and zinc, new meta-analyses were performed as part of this work.
Our meta-analyses of 10 articles on n-3 PUFAs and four on zinc support their efficacy. For folic acid, our meta-analysis does not support efficacy. For n-3 PUFAs, sensitivity analysis showed no difference between acceleration and augmentation designs, but significant differences between individuals with or without comorbidities. For the remaining substances, only a few RCTs were available. The preliminary data on inositol was negative, while one RCT for vitamin D demonstrated positive results. For vitamin B12 one and for SAMe two RCTs and a few open trials are available reporting positive and mixed results. To summarize, for most of the substances, the available data is not yet sufficient or inconclusive.

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