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Breast milk resulted in 20 ng of vitamin D for infant if mother had taken 5,000 IU daily – RCT Dec 2013

Maternal Vitamin D Supplementation to Improve the Vitamin D Status of Breast-fed Infants: A Randomized Controlled Trial

Mayo Clinic Proceedings. Volume 88, Issue 12 , Pages 1378-1387, December 2013
Sara S. Oberhelman, MD Oberhelman.sara at mayo.edu, Michael E. Meekins, PharmD, Philip R. Fischer, MD , Bernard R. Lee, PharmD , Ravinder J. Singh, PhD , Stephen S. Cha, MS , Brian M. Gardner, PharmD , John M. Pettifor, MB, BCh, PhD , Ivana T. Croghan, PhD , Tom D. Thacher, MD

Objective: To determine whether a single monthly supplement is as effective as a daily maternal supplement in increasing breast milk vitamin D to achieve vitamin D sufficiency in their infants.

Patients and Methods: Forty mothers with exclusively breast-fed infants were randomized to receive oral cholecalciferol (vitamin D3) 5000 IU/d for 28 days or 150,000 IU once. Maternal serum, breast milk, and urine were collected on days 0, 1, 3, 7, 14, and 28; infant serum was obtained on days 0 and 28. Enrollment occurred between January 7, 2011, and July 29, 2011.

Results: In mothers given daily cholecalciferol, concentrations of serum and breast milk cholecalciferol attained steady levels of 18 and 8 ng/mL, respectively, from day 3 through 28. In mothers given the single dose, serum and breast milk cholecalciferol peaked at 160 and 40 ng/mL, respectively, at day 1 before rapidly declining. Maternal milk and serum cholecalciferol concentrations were related (r=0.87).

Infant mean serum 25-hydroxyvitamin D concentration increased from

  • 17±13 to 39±6 ng/mL in the single-dose group and from
  • 16±12 to 39±12 ng/mL in the daily-dose group (P=.88).

All infants achieved serum 25-hydroxyvitamin D concentrations of more than 20 ng/mL.

Conclusion: Either single-dose or daily-dose cholecalciferol supplementation of mothers provided breast milk concentrations that result in vitamin D sufficiency in breast-fed infants.

clinicaltrials.gov NCT01240265

Summaries by VitaminDWiki

Peaks of single dose were 4X less in breast milk

Serum 160 ng
Breast milk 40 ng

Dose to motherInfant @ 30 days
5,000 IU daily 39.2 ng
150,000 IU monthly38.7 ng

See also VitaminDWiki

see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=2475

Healthy pregnancies need lots of vitamin D has the following summary

1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT*
3. Gestational Diabetes 3 times RCT*
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT*
6. C-section - unplanned 1.6 timesObserve
7. Depression AFTER pregnancy 1.4 times RCT*
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT*
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT*
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT*
16. Childhood Respiratory Tract visits 2.5 times RCT*


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