Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review.
Int J Endocrinol. 2016;2016:8347379. doi: 10.1155/2016/8347379. Epub 2016 Apr 6.
Stakisaitis D1, Lesauskaitė V2, Girdauskaitė M3, Janulionis E4, Ulys A5, Benetis R6.
Cardiovascular category starts with the following
- Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Stroke and vitamin D
- Heart Attack 326 items as of March 2017
- Arrhythmia OR “atrial fibrillation” 215 items as of Oct 2017
- (Arrhythmia OR “atrial fibrillation”) AND Magnesium 101 items as of Sept 2016
- "C-Reactive Protein" 499 items as of March 2017
- TRIGLYCERIDES 421 items as of March 2017
- "Peripheral Artery Disease" 81 items as of Oct 2017
- "Sudden Cardiac Arrest" 35 items as of March 2017
- Search VitaminDWiki for CHF or "HEART FAILURE" 1220 items as of Aug 2017
- Search VitaminDWiki for Atherosclerosis 726 items as of Oct 2017
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and vitamin D statins often reduce levels of vitamin D
Items in both categories Cardiovascular and VDBP are listed here:
- Coronary Artery Disease risk both increased and decreased by 30 percent with mutations in Vitamin D Binding – April 2016
- Coronary Heart Disease 57 percent more likely if poor Vitamin D Binding Protein with high PTH – Nov 2017
- Vitamin D Binding Protein and Coronary artery disease – Oct 2017
- Heart Disease 40 percent more likely in women having poor Vitamin D Binding Protein – Sept 2017
The aim of the study was to assess the effect of vitamin D-binding protein (DBP) polymorphism on coronary artery disease (CAD). DBP phenotypes were identified in the groups: control (n = 306), men suffering from CAD (n = 154), and long-lived individuals (n = 108). Isoelectric focusing of DBP phenotypes in serum was performed on polyacrylamide gel. Distribution of DBP phenotypes in the study groups was found to be in Hardy-Weinberg equilibrium. Gc1s-1s phenotype and Gc1s allele frequency in CAD groups were significantly higher than in control, and Gc1s allele frequency was found significantly more often in CAD compared with long-lived group (p < 0.05). The Gc2 allele frequency in control was higher as compared with Gc2 frequency in CAD group (p < 0.05). The Gc2-2 phenotype was more frequent in long-lived survivors than in the CAD group (p < 0.05). It was found that the Gc1s allele significantly increased the risk of CAD with the odds ratio (OR) equal to 1.45 (p < 0.02) and showed Gc2 to be related with a decreased risk of CAD (OR = 0.69; p < 0.03). Authors review the role of DBP in resistance to atherosclerosis and cancer as the main longevity determinants.
PMID: 27143969 PMCID: PMC4837253 DOI: 10.1155/2016/8347379
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