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Heart Disease 40 percent more likely in women having poor Vitamin D Binding Protein – Sept 2017

Independent and Synergistic Associations of Biomarkers of Vitamin D Status With Risk of Coronary Heart Disease

Arteriosclerosis, Thrombosis, and Vascular Biology. 2017;37:2204-2212, Sept 7, 2017, https://doi.org/10.1161/ATVBAHA.117.309548
Lu Qi, Wenjie Ma, Yoriko Heianza, Yan Zheng, Tiange Wang, Dianjianyi Sun, Eric B. Rimm, Frank B. Hu, Edward Giovannucci, Christine M. Albert, Kathryn M. Rexrode, JoAnn E. Manson

VitaminDWiki

Poor Vitamin D Binding Protein is more associated with dark skin than Heart Disease
Wonder how many of the participants in this study had dark skin

Genetics category listing contains the following

206 articles in Genetics the category

 

see also 186 articles in Vitamin D Receptor, 78 articles in Vitamin D Binding Protein

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki - (subject to many future developments)
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, andi in 2017 is speculated to be 90%
  • Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells appears feasible (personal communication)
    However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
       especially if it is one of 37+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are poor
    4) Back Pain
        probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
          The founder of VitaminDWiki took action with clues #3&4

Additional information on the Genes in VitaminDWiki

Gene# of pages
Oct 2017
Location
CPY27A1223 Liver
CYP2R1 626Tissue
Vitamin D Binding Protein 3,450 Blood
CYP27B1803Kidney & Tissue
Vitamin D Receptor 6,030Cell Tissue
CYP24A1 745 excrete excess

See also PubMed


Objective—To comprehensively evaluate the independent associations and potential interactions of vitamin D–related biomarkers including total and bioavailable 25-hydroxyvitamin D (25OHD), VDBP (vitamin D binding protein), and parathyroid hormone (PTH) with risk of coronary heart disease (CHD).

Approach and Results—We prospectively identified incident cases of nonfatal myocardial infarction and fatal CHD among women in the Nurses’ Health Study during 20 years of follow-up (1990–2010). Using risk-set sampling, 1 to 2 matched controls were selected for each case. The analysis of 25OHD and PTH included 382 cases and 575 controls; the analysis of VDBP included 396 cases and 398 controls. After multivariate adjustment, plasma levels of total 25OHD, bioavailable 25OHD, and PTH were not significantly associated with CHD risk.
VDBP was associated with a lower CHD risk with an extreme-quartile odds ratio of 0.60 (95% confidence interval, 0.39–0.92; P trend=0.02). When examining the biomarkers jointly, a significant, inverse association between 25OHD and CHD was observed among participants with higher PTH levels (P for interaction=0.02).
The odds ratio (95% confidence interval) comparing the highest quartile of 25OHD to lowest was 0.43 (0.23–0.82; P trend=0.003) when PTH levels were above population median (35.3 pg/mL), whereas among the rest of participants the corresponding odds ratio (95% confidence interval) was 1.28 (0.70–2.36; P trend=0.43).

Conclusions—Our data suggest that higher 25OHD levels were associated with a lower CHD risk when PTH levels were high, whereas no association was observed for participants with low PTH levels. VDBP but not bioavailable 25OHD was independently associated with lower CHD risk.

Publisher wants $35 for the PDF

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