Mechanisms of Vitamin D Deficiency as a Risk Factor for Post-Stroke Depression, Dementia, Delirium, and Fatigue : A Promising Therapeutic Modality
Journal of Affective Disorders Reports https://doi.org/10.1016/j.jadr.2025.100960
Acute ischemic stroke often results in a multitude of neuropsychiatric complications, including depression, dementia, delirium, and fatigue. Research has demonstrated a positive correlation between lower serum vitamin D levels and an elevated risk of these post-stroke symptoms, albeit the precise underlying mechanisms remain incompletely understood. Existing studies indicate that vitamin D deficiency can impair normal immune function, decrease neurotransmitter synthesis, exacerbate oxidative stress damage, and disrupt calcium ion homeostasis. This review consolidates findings from various studies, highlighting the strong association between vitamin D deficiency and abnormal post-stroke symptoms. Furthermore, it elucidates the pivotal role of vitamin D in modulating inflammatory responses, mitigating oxidative stress, and facilitating neurotransmitter synthesis. Based on these insights, we propose vitamin D as a promising therapeutic target for both preventing and alleviating abnormal post-stroke symptoms.
Download the PDF from VitaminDWiki
See related in VitaminDWiki
- 17 Ways to Cut Your Risk of Stroke, Dementia and Depression (Vitamin D cuts 10 of them) - April 2025
- Depression following a stroke is 2.7 X more likely if low vitamin D – Sept 2018
- Post stroke depression 9X more likely if low vitamin D – Dec 2014
- Stroke patients with low vitamin D were 10X more likely to become depressed – Aug 2014
- 17 Ways to Cut Your Risk of Stroke, Dementia and Depression (Vitamin D cuts 10 of them) - April 2025
- Post-stroke fatigue cut in half by Vitamin D (just 600 IU daily in 3 months) – Nov 2021
- Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015
47,000 items in stroke (Dementia OR Delirium OR Fatigue) "vitamin d” – Google Scholar
- A systematic review examining the effect of vitamin D supplementation
on functional outcomes post-stroke – May 2023 FREE PDF - Vitamin D deficiency and post-stroke depression:
A systematic review and meta-analysis Sept 2023 FREE PDF - Association of a low vitamin D status with risk of post-stroke depression:
A meta-analysis and systematic review Feb 2023 FREE PDF - Preoperative vitamin D deficiency and postoperative delirium risk:
multicenter retrospective study - July 2025 FREE PDF