Periodontal Inflammation in seniors ceases to increase when Vitamin D is higher than 27 ng – Sept 2023

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Serum levels of vitamin D and periodontal inflammation in community-dwelling older Japanese adults: The Otassha Study

J Clin Periodontol. 2023 Sep;50(9):1167-1175. doi: 10.1111/jcpe.13834
Masanori Iwasaki 1 2, Keiko Motokawa 1, Maki Shirobe 1, Misato Hayakawa 1, Yuki Ohara 1, Yoshiko Motohashi 1, Ayako Edahiro 1, Hisashi Kawai 1, Yoshinori Fujiwara 1, Yasuyuki Sakata 3, Kazushige Ihara 4, Yutaka Watanabe 1 5, Shuichi Obuchi 1, Hirohiko Hirano 1

Aim: To evaluate the association between vitamin D status and periodontal inflammation as determined by the periodontal inflamed surface area (PISA) in community-dwelling older adults.

Materials and methods: This cross-sectional study included 467 Japanese adults (mean age = 73.1 years) who underwent full-mouth periodontal examinations and measurements of serum levels of 25-hydroxyvitamin D (25(OH)D). We used linear regression and restricted cubic spline models to analyse the association between exposure (serum 25(OH)D) and outcome (PISA).

Results: The linear regression model showed that, after adjusting for potential confounders, participants in the lowest quartile of serum 25(OH)D had 41.0 mm2 more PISA (95% confidence interval [CI]: 4.6-77.5) than the reference group (the highest quartile of serum 25(OH)D). The spline model showed that the association between serum 25(OH)D and PISA was non-linear and restricted to the low 25(OH)D range. PISA initially sharply decreased as serum 25(OH)D increased, and then the decreasing trend slowed and plateaued. The inflection point with the minimum PISA value was a serum 25(OH)D level of 27.1 ng/mL, above which there was no decreasing trend in PISA with increasing serum 25(OH)D levels.

Conclusions: Low vitamin D status had an L-shaped association with periodontal inflammation in this cohort of Japanese adults.

>50 References are online

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VitaminDWiki – Dental category contains

115 Dental items

Some Dental studies

• Vitamin D cut dental caries in half 80 years ago – meta-analysis 2013 80 years ago
• Caries (tooth decay) and Vitamin D - 23+ studies
• Periodontitis reduced by Vitamin D - many studies
  • Periodontal Disease and Vitamin D - interview and transcript - GRH, Grant July 2023
  • Severe periodontitis is half as likely at 60 ng of vitamin D – Sept 2021
  • Vitamin D may provide the most peridontal benefits of all nutraceuticals – May 2018
• Risk of Oral Surgery reduced by Vitamin D – scoping review Nov 2021
• Some Dental Malocclusions 5X more likely if low vitamin D – June 2021
• Grinding teeth while sleeping (sleep bruxism) 6 X more likely if low vitamin D – Jan 2021
• Early tooth decay 1.9 X more likely if a poor Vitamin D receptor – July 2017
• 7 Intervention AND Dental studies
• 19 items listed in BOTH Dental and Infant or Child
• 7 listed in BOTH Dental and Vitamin D Receptor

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25+ VitaminDWiki pages with PERIODONT.. in the title

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