Lower vitamin D levels are associated with the pathogenesis of inflammatory bowel diseases
Medicine (Baltimore). 2023 Oct 13;102(41):e35505. doi: 10.1097/MD.0000000000035505.
Antonia Topalova-Dimitrova 1 2, Ivan Valentinov Dimitrov 2 3, Rosen Nikolov 1 2
Vitamin D plays a role in regulating immune homeostasis, inflammation and has an impact on the pathogenesis of inflammatory bowel diseases (IBD). IBD has a multifactorial pathogenesis primarily associated with immune dysregulation, dysbiosis, structurally altered intestinal mucosa, and genetic factors. The immunomodulatory function of this vitamin is linked to its control over innate and adaptive immunity, facilitated through its nuclear vitamin D receptor, leading to the inhibition of nuclear factor kappa-B. This study aimed to investigate serum vitamin D levels in patients with IBD compared to healthy individuals and to evaluate the relationship between vitamin D and inflammatory markers. Cross-sectional study. The study included 106 participants divided into 2 groups: patients with IBD (92), and healthy controls (14). The diagnosis of IBD was based on clinical, laboratory, fecal, endoscopic, and histological findings, following the European guidelines for diagnosis and follow-up ECCO-ESGAR guidelines for diagnostic assessment of IBD from 2019. Serum vitamin D levels were measured along with laboratory tests, imaging, and endoscopic examinations. IBD activity was evaluated using the Montreal classification and clinical and endoscopic indices. Data analysis involved calculating the mean, minimum, and maximum values, standard deviation, and Pearson coefficient. The level of statistical significance for this study was set at P < .05. The study found a prevalence of vitamin D deficiency in 32.6% of patients with IBD, while 66.3% had insufficiency, as compared with healthy individuals. The mean levels of vitamin D in UC and CD were 16 ± 8.6 ng/mL, whereas in the control healthy group, they were 26 ± 9.73 ng/mL. A statistically significant reverse correlation was observed between lower vitamin D levels and higher levels of the inflammatory markers. The study concluded that IBD patients exhibit lower levels of vitamin D, which is associated with inflammation and may contribute to the pathogenesis of the disease.
No such attachment on this page
30+ VitaminDWiki pages with IBD in title
This list is automatically updated
Items found: 30
|
Title |
|
Modified |
|
Vitamin D interactions with poor gut (Celiac, IBD, and Bariatric surgery) – several studies |
|
22 Nov, 2023 |
|
IBD associated with low vitamin D again (they need to take a gut-friendly form of Vitamin D) – Oct 2023 |
|
14 Oct, 2023 |
|
IBD treated in children by Vitamin D, especially if use more than 2,000 IU daily for 12 weeks – meta-analysis – Sept 2022 |
|
14 Sep, 2022 |
|
Vitamin D fights IBD, no consensus yet on dose size and type – Aug 2022 |
|
26 Aug, 2022 |
|
IBD is treated by Vitamin D and other Nutraceuticals – June 2022 |
|
23 Jun, 2022 |
|
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 |
|
30 May, 2022 |
|
IBD in children might be associated with low sun exposure |
|
28 Feb, 2022 |
|
IBD strongly associated with low Vitamin D – Jan 2022 |
|
09 Jan, 2022 |
|
IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021 |
|
29 Jun, 2021 |
|
IBD and UV dissertation - 2019 |
|
10 Sep, 2019 |
|
Vitamin D appears to fight Diabetes, MS, RA, Lupus, IBD, Hepatitis, Cancer, Psoriasis, Food allergy, etc – June 2019 |
|
17 Jul, 2019 |
|
IBD in Finland – 3X increase in 15 years, more prevalent further from equator – Nov 2012 |
|
14 May, 2019 |
|
Common cold incidence reduced by two thirds (500 IU for IBD with low vitamin D) – RCT Jan 2019 |
|
04 Jan, 2019 |
|
Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018 |
|
09 Dec, 2018 |
|
IBD relapse rate reduced by low Vitamin D - meta-analysis Nov 2018 |
|
27 Nov, 2018 |
|
Higher Vitamin D increased the benefit of anti-TNF- α drug used for IBD by 2.6 times – Jan 2017 |
|
31 Jan, 2017 |
|
IBD in Canadian children increasing 7% per year - Nov 2016 |
|
22 Nov, 2016 |
|
IBD UC and CD at risk of being vitamin D deficient – May 2011 |
|
04 Nov, 2016 |
|
IBD deficiencies of Iron and Vitamin D (and new Iron types) – June 2016 |
|
20 Jun, 2016 |
|
IBD helped by vitamin D but reluctant to state who helped, in what form, and how much – review Nov 2014 |
|
08 Jan, 2016 |
|
IBD more likely in areas with low UV ( and thus low vitamin D) – June 2014 |
|
05 Dec, 2015 |
|
Gut problems more likely if low vitamin D (IBD: 1.6, UC: 2.3) – meta-analysis Aug 2015 |
|
31 Oct, 2015 |
|
IBD (Collitis, Chron’s) was active 6X more often if low vitamin D – June 2015 |
|
03 Oct, 2015 |
|
Crohn’s disease deficient in vitamin K – IBD deficient in vitamins K and D – April 2011 |
|
17 Feb, 2015 |
|
Appears that IBD lowers vitamin D, which increases risk of cancer by 80 percent – Oct 2013 |
|
09 Jul, 2014 |
|
IBD surgery 5X more likely for non-caucasians with low vitamin D – Oct 2012 |
|
03 Nov, 2012 |
|
IBD and Crohn but not Colitis associated with low vitamin D – May 2011 |
|
05 Jun, 2012 |
|
IBD colorectal Cancer and vitamin D – Jan 2011 |
|
14 Mar, 2012 |
|
Dogs – like humans – with IBD were low on vitamin D – July 2011 |
|
14 Mar, 2012 |
|
IBD less costly when treated with vitamin D3 compared to D2 – Jan 2012 |
|
12 Jan, 2012 |
A gut that has poor digestion does much better gut-friendly forms of Vitamin D
- A form that is easily digested
- A form that does not require the gut (topical, sublingual, spray, etc)