Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty.
Front Med. 2017 Aug 8. doi: 10.1007/s11684-017-0544-5. [Epub ahead of print]
Zhao Y1, Long W1, Du C1, Yang H1, Wu S1, Ning Q2, Luo X3.
- 1 Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
- 2 Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
- 3 Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. xpluo at tjh.tjmu.edu.cn.
The relationship between vitamin D deficiency and idiopathic central precocious puberty (ICPP) has been recently documented. In this study, 280 girls diagnosed with ICPP and 188 normal puberty control girls of similar ages were enrolled and retrospectively studied. The ICPP group had significantly lower serum 25-hydroxyvitamin D (25[OH]D) levels than the control group. Furthermore, a nonlinear relationship was found between serum 25[OH]D and ICPP, and a cut-off point for serum 25[OH]D was found at 31.8 ng/ml for ICPP with and without adjusting the different confounding factors.
Girls with serum 25[OH]D ≥ 31.8 ng/ml had a lower odds ratio (
- unadjusted: OR 0.36, 95% CI 0.15 to 0.83, P < 0.05;
- height and weight adjusted: OR 0.44, 95% CI 0.18 to 1.08, P = 0.072;
- BMI adjusted: OR 0.36, 95% CI 0.16 to 0.84, P < 0.05).
The ICPP subjects with 25[OH]D deficiency had a higher body mass index (BMI) than the subjects from the two other subgroups. Correlation analysis showed that vitamin D level is correlated with BMI and some metabolic parameters in the ICPP group. Our study suggested that vitamin D status may be associated with ICPP risk and may have a threshold effect on ICPP.
PMID: 28791667 DOI: 10.1007/s11684-017-0544-5
- 1 Harel Z, Flanagan P, Forcier M, Harel D. Low vitamin D status among obese adolescents: prevalence and response to treatment. J Adolesc Health 2011; 48(5): 448–452
- 2 Roth CL, Elfers C, Kratz M, Hoofnagle AN. Vitamin d deficiency in obese children and its relationship to insulin resistance and adipokines. J Obes 2011; 2011: 495101
- 3 Ganji V, Zhang X, Shaikh N, Tangpricha V. Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25-hydroxyvitamin D data from NHANES 2001-2006. Am J Clin Nutr 2011; 94(1): 225–233
- 4 Madden K, Feldman HA, Smith EM, Gordon CM, Keisling SM, Sullivan RM, Hollis BW, Agan AA, Randolph AG. Vitamin D deficiency in critically ill children. Pediatrics 2012; 130(3): 421–428
- 5 Pilz S, Verheyen N, Grübler MR, Tomaschitz A, März W. Vitamin D and cardiovascular disease prevention. Nat Rev Cardiol 2016; 13(7): 404–417
- 6 Temmerman JC. Vitamin D and cardiovascular disease. J Am Coll Nutr 2011; 30(3): 167–170
- 7 Nicholas C, Davis J, Fisher T, Segal T, Petti M, Sun Y, Wolfe A, Neal-Perry G. Maternal vitamin D deficiency programs reproductive dysfunction in female mice offspring through adverse effects on the neuroendocrine axis. Endocrinology 2016; 157(4): 1535–1545
- 8 Knight JA, Wong J, Blackmore KM, Raboud JM, Vieth R. Vitamin D association with estradiol and progesterone in young women. Cancer Causes Control 2010; 21(3): 479–483
- 9 Villamor E, Marin C, Mora-Plazas M, Baylin A. Vitamin D deficiency and age at menarche: a prospective study. Am J Clin Nutr 2011; 94(4): 1020–1025
- 10 Chew A, Harris SS. Does vitamin D affect timing of menarche? Nutr Rev 2013; 71(3): 189–193
- 11 Lee HS, Kim YJ, Shim YS, Jeong HR, Kwon E, Hwang JS. Associations between serum vitamin D levels and precocious puberty in girls. Ann Pediatr Endocrinol Metab 2014; 19(2): 91–95
- 12 Oliveira RM, Novaes JF, Azeredo LM, Cândido AP, Leite IC. Association of vitamin D insufficiency with adiposity and metabolic disorders in Brazilian adolescents. Public Health Nutr 2014; 17(4): 787–794
- 13 Walsh JS, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Jacques RM, Eastell R. Free 25-hydroxyvitamin D is low in obesity, but there are no adverse associations with bone health. Am J Clin Nutr 2016; 103(6): 1465–1471
- 14 Colmenares A, Gunczler P, Lanes R. Higher prevalence of obesity and overweight without an adverse metabolic profile in girls with central precocious puberty compared to girls with early puberty, regardless of GnRH analogue treatment. Int J Pediatr Endocrinol 2014; 2014(1): 5
- 15 Burt Solorzano CM, McCartney CR. Obesity and the pubertal transition in girls and boys. Reproduction 2010; 140(3): 399–410
- 16 Subspecialty Group of Endocrinologic HaMD, the Society of Pediatrics, Chinese Medical Association. Consensus statement for the diagnosis and treatment of central precocious puberty (2015). Chin J Pediatr (Zhonghua Er Ke Za Zhi) 2015; 53(6): 412–418 (in Chinese)
- 17 Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 2011; 96(1): 53–58
- 18 Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011; 96(7): 1911–1930
- 19 Fu JF, Liang JF, Zhou XL, Prasad HC, Jin JH, Dong GP, Rose SR. Impact of BMI on gonadorelin-stimulated LH peak in premenarcheal girls with idiopathic central precocious puberty. Obesity (Silver Spring) 2015; 23(3): 637–643
- 20 Greulich WW, Pyle SI. Radiologic Atlas of Skeletal Development of the Hand and Wrist. Stanford, California: Stanford University Press 1959,91(1): 53
- 21 Brown RJ, Yanovski JA. Estimation of insulin sensitivity in children: methods, measures and controversies. Pediatr Diabetes 2014; 15(3): 151–161
- 22 Rosen CJ, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Manson JE, Mayne ST, Ross AC, Shapses SA, Taylor CL. IOM committee members respond to Endocrine Society vitamin D guideline. J Clin Endocrinol Metab 2012; 97(4): 1146–1152
- 23 Hollis BW, Wagner CL. Normal serum vitamin D levels. N Engl J Med 2005; 352(5): 515–516
- 24 Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr 2005; 135(2): 317–322
- 25 Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology 2000; 141(4): 1317–1324
- 26 Johnson LE, DeLuca HF. Reproductive defects are corrected in vitamin D-deficient female rats fed a high calcium, phosphorus and lactose diet. J Nutr 2002; 132(8): 2270–2273
- 27 Dicken CL, Israel DD, Davis JB, Sun Y, Shu J, Hardin J, Neal-Perry G. Peripubertal vitamin D(3) deficiency delays puberty and disrupts the estrous cycle in adult female mice. Biol Reprod 2012; 87(2): 51
- 28 Kitagawa I, Kitagawa Y, Kawase Y, Nagaya T, Tokudome S. Advanced onset of menarche and higher bone mineral density depending on vitamin D receptor gene polymorphism. Eur J Endocrinol 1998; 139(5): 522–527
- 29 Gilbert-Diamond D, Baylin A, Mora-Plazas M, Marin C, Arsenault JE, Hughes MD, Willett WC, Villamor E. Vitamin D deficiency and anthropometric indicators of adiposity in school-age children: a prospective study. Am J Clin Nutr 2010; 92(6): 1446–1451
- 30 Gutiérrez Medina S, Gavela-Pérez T, Domínguez-Garrido MN, Gutiérrez-Moreno E, Rovira A, Garcés C, Soriano-Guillén L. The influence of puberty on vitamin D status in obese children and the possible relation between vitamin D deficiency and insulin resistance. J Pediatr Endocrinol Metab 2015; 28(1-2): 105–110
- 31 Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72(3): 690–693
- 32 Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and metaanalysis. J Clin Endocrinol Metab 2007; 92(6): 2017–2029
- 33 Shin YH, Kim KE, Lee C, Shin HJ, Kang MS, Lee HR, Lee YJ. High prevalence of vitamin D insufficiency or deficiency in young adolescents in Korea. Eur J Pediatr 2012; 171(10): 1475–1480
- 34 Breen ME, Laing EM, Hall DB, Hausman DB, Taylor RG, Isales CM, Ding KH, Pollock NK, Hamrick MW, Baile CA, Lewis RD. 25-hydroxyvitamin D, insulin-like growth factor-I, and bone mineral accrual during growth. J Clin Endocrinol Metab 2011; 96(1): E89–E98
- 35 Daftary SS, Gore AC. IGF-1 in the brain as a regulator of reproductive neuroendocrine function. Exp Biol Med (Maywood) 2005; 230(5): 292–306
- 36 Ciresi A, Cicciò F, Giordano C. High prevalence of hypovitaminosis D in Sicilian children affected by growth hormone deficiency and its improvement after 12 months of replacement treatment. J Endocrinol Invest 2014; 37(7): 631–638
- 37 Tsuji K, Maeda T, Kawane T, Matsunuma A, Horiuchi N. Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1α,25-dihydroxyvitamin D3 synthesis in leptindeficient mice. J Bone Miner Res 2010; 25(8): 1711–1723