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Early puberty in girls 60 percent more likely if less than 32 ng of vitamin D – Aug 2017

Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty.

Front Med. 2017 Aug 8. doi: 10.1007/s11684-017-0544-5. [Epub ahead of print]

Zhao Y1, Long W1, Du C1, Yang H1, Wu S1, Ning Q2, Luo X3.

  • 1 Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • 2 Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
  • 3 Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. xpluo at tjh.tjmu.edu.cn.

The relationship between vitamin D deficiency and idiopathic central precocious puberty (ICPP) has been recently documented. In this study, 280 girls diagnosed with ICPP and 188 normal puberty control girls of similar ages were enrolled and retrospectively studied. The ICPP group had significantly lower serum 25-hydroxyvitamin D (25[OH]D) levels than the control group. Furthermore, a nonlinear relationship was found between serum 25[OH]D and ICPP, and a cut-off point for serum 25[OH]D was found at 31.8 ng/ml for ICPP with and without adjusting the different confounding factors.
Girls with serum 25[OH]D ≥ 31.8 ng/ml had a lower odds ratio (

  • unadjusted: OR 0.36, 95% CI 0.15 to 0.83, P < 0.05;
  • height and weight adjusted: OR 0.44, 95% CI 0.18 to 1.08, P = 0.072;
  • BMI adjusted: OR 0.36, 95% CI 0.16 to 0.84, P < 0.05).

The ICPP subjects with 25[OH]D deficiency had a higher body mass index (BMI) than the subjects from the two other subgroups. Correlation analysis showed that vitamin D level is correlated with BMI and some metabolic parameters in the ICPP group. Our study suggested that vitamin D status may be associated with ICPP risk and may have a threshold effect on ICPP.

PMID: 28791667 DOI: 10.1007/s11684-017-0544-5

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