Epidemiology of Vitamin D And Colorectal Cancer.
Anticancer Agents Med Chem. 2012 Oct 12.
Giovannucci E., Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, U.S.A. egiovann at hsph.harvard.edu.
Garland and Garland first hypothesized that better vitamin D status lowered risk of colorectal cancer in 1980. Subsequently, the relation between vitamin D status and colorectal cancer risk has been investigated in epidemiologic studies. Various approaches have been used to estimate vitamin D status, including direct measures of circulating 25(OH)vitamin D levels, surrogates or determinants of vitamin D (including region of residence, intake, and sun exposure estimates, or a combination of these).
These measures of vitamin D status have been studied in relation to colorectal adenoma, precursors of cancer, and colorectal cancer incidence and mortality.
In general, all lines of inquiry from observational studies indicate that better vitamin D status is associated with lower colorectal cancer risk. While most of the studies have examined vitamin D status in relation to risk of incident colorectal cancer, some evidence suggests that vitamin D may be additionally important for colorectal cancer progression and mortality.
Although the influence of confounding factors cannot be entirely excluded, the consistency of the association using various approaches to measure vitamin D, for diverse endpoints and in diverse populations shows high consistency and is strongly suggestive of a causal association.
Thus, improving vitamin D status could be potentially beneficial against colorectal cancer incidence and mortality.
See also VitaminDWiki
- Colorectal cancer 60 percent less likely if have more than 50 ng of vitamin D (vs 5 ng) – meta-analysis April 2017
- Colorectal cancer 60 percent less likely: high vs low Vitamin D level – meta-analysis Dec 2016
- Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015
- Overview Cancer-Colon and vitamin D which includes the following chart