Poor Receptor predicts sepsis death (restricts Vitamin D from getting to cells)

Created August 2021

Novel biomarker for predicting sepsis mortality: vitamin D receptor

Journal of International Medical Research https://doi.org/10.1177/03000605211034733

Murat Erdoğan, Hüseyin Avni FındıklıFirst

* *There are 2 easy ways to get past a VDR restriction 1) Take Vitamin D in high, infrequent doses 2) Take one of more supplements that have been proven to activate the receptor * 1. Items in both categories VDR and Mortality: {category} The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019 * Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc** Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators Note: My father-in-law got sepsis in the hospital. I immediately gave him 200,000 IU of Vitamin D. He left hospital 3 days later --- I had not heard of an ELISA test kit for the VDR. This study got their $400 oil - (research purposes only) from https://www.mybiosource.com/ --- 1. VitaminDWiki pages containing SEPSIS in title {LIST()}

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Objective

There are currently no studies on the role of vitamin D receptor (VDR) levels as a cause of or risk factor for sepsis. We aimed to establish the association between VDR levels and 28-day mortality in critically ill patients with sepsis.

Methods

This prospective cross-sectional observational study included 148 patients diagnosed with sepsis who were treated in the intensive care unit. We measured VDR levels, laboratory characteristics, and health scores and related them to survival.

Results

The 148 patients included 96 survivors and 52 non-survivors, with VDR levels of 1.92 and 1.36 ng/mL, respectively. Baseline VDR was a significant predictor of 28-day mortality, with an area under the curve of 0.778. A low VDR level was significantly associated with lower overall survival in patients with sepsis according to Kaplan–Meier curve analysis. VDR levels were also negatively correlated with lactate, C-reactive protein, acute physiological and clinical health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores, and disease severity.

Conclusions

VDR levels were associated with high 28-day mortality and negatively correlated with lactate, C-reactive protein, APACHE II and SOFA scores, and disease severity in patients with sepsis. VDR levels can predict poor outcomes in patients with sepsis.

Tags: Mortality Trauma and surgery Vit D Receptor