Poor prognosis of solid childhood cancers 14.7 X more likely with a poor Vitamin D Receptor

Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid Tumors

Cancers (Basel). 2022 Jul 6;14(14):3295. doi: 10.3390/cancers14143295.

Orsolya Juhász 1, Noémi Jákob 2, Hajnalka Rajnai 2, Marcell Imrei 3 4, Miklós Garami 1

Background: Our previous work has shown a correlation between lower vitamin D levels in children with cancer and adverse prognosis. It suggests that supplying vitamin D is reasonable. VDR expression in childhood solid tumors has been linked to tumor characteristics and patient survival in only a few studies.

Methods: For this study, 177 children with solid tumors were selected whose biopsies and tumor tissue formalin-fixed, paraffin-embedded tissue blocks were available for immunohistochemical analysis at Semmelweis University, Budapest (Hungary).

Results: We found that non-significant VDR expression was associated with a significantly less favorable prognosis (p = 0.0061) in the examined childhood solid tumors. There was a clinically significant association; non-significant VDR expression had more than 14-fold odds of an unfavorable prognosis ( OR = 14.74 ). The rate of VDR expression differed significantly between tumor types (p <0.0001).

Conclusion: In conclusion, VDR expression measured by IHC staining is inversely associated with aggressive characteristics in different childhood cancers. The downregulation of VDR expression in more aggressive childhood cancers suggests that functional vitamin D activity may slow or block cancer progression.

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Sometimes A Disease ==> deactivates VDR, typically poor VDR ==> increased risk

• Breast Cancer reduces receptor and thus blocks Vitamin D to the cells – several studies

• A virus that most adults have (Cytomegalovirus) decreases the amount of Vitamin D which gets to the cells – Jan 2017

• Epstein-Barr is yet another virus that deactivates the Vitamin D receptor (COVID later suspected as well)– 2010

• COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021

Suspect increased incidence of poor VDR in past 50 years

Now a person can survive a poor VDR and pass a poor VDR gene onto their offspring

This lack of the survival of the fittest may be a major reason for the increase of health problems, such as childhood cancers

Have been unable to find studies of trends of VDR incidence

• Incidence of 22 health problems related to vitamin D have doubled in a decade - many charts

VitaminDWiki - Vitamin D Receptor category contains

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Cancer is the most frequent health problem of VDR studies

📄 Trend research of vitamin D receptor: Bibliometric analysis: 2021 PDF

VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways

Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise, Butyrate   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators

78 Cancer studies in VitaminDWiki were associated with poor VDR (as of July 2022)

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