Parathyroid increase with age associated with worsening Vitamin D genes

Created May 2020

Older Age Is Associated With Decreased Levels of VDR, CYP27B1, and CYP24A1 and Increased Levels of PTH in Human Parathyroid Glands

Int J Endocrinol. 2020 Apr 9;2020:7257913. doi: 10.1155/2020/7257913. eCollection 2020.

Yi Jiang 1, Liyan Liao 1, Jina Li 2, Larry Wang 3, Zhongjian Xie 4

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* Parathyroid Hormone levels increase 63 percent with age (33,000 people) – Sept 2017 * PTH does not plateau with increasing vitamin D, but does decrease with patient age – Aug 2012 * Parathyroid hormone level is inversely associated with both Vitamin D and age – April 2021 * Vitamin D titles containing PTH OR Parathyroid 39 pages as of June 2021 1. Genetics category listing contains the following {include} 1. # Items in both categories Thyroid/para and VDR are listed here: {category} Vitamin D Receptor is associated in over 58 autoimmune studies The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019 * Omega-3,  Magnesium, Zinc,  Quercetin,  non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc**  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

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Parathyroid glands contain the vitamin D receptor (VDR) and 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) and 24-hydroxylase (CYP24A1), which catalyze the production and degradation of 1,25-dihydroxyvitamin D [1,25(OH)2D], respectively. Previous studies have shown that the serum level of intact parathyroid hormone (iPTH) increases with age. We hypothesized that the expression of CYP27B1 or VDR in parathyroid glands decreases with age, which might account for the increased serum levels of iPTH due to decreased suppression of parathyroid hormone (PTH) secretion by 1,25(OH)2D in older people. To test this hypothesis, we examined relative expression levels of VDR, CYP27B1, CYP24A1, and PTH in specimens from parathyroid glands unintentionally removed during thyroidectomy for 70 patients varying in age from 10 to 70 years. The results showed that there was an inverse correlation between age and VDR, CYP27B1, and CYP24A1 expression (p < 0.05). A significant positive correlation between PTH expression levels and age was also observed (p < 0.05).

These data indicate that older age is associated with decreased levels of VDR, CYP27B1, and CYP24A1 and increased levels of PTH in human parathyroid glands.

Tags: CYP27B1 Genetics Seniors Thyroid and parathyroid Vit D Receptor