Poor Vitamin D receptor reduced vitamin D levels -meta-analysis
Note: Most studies find poor VDR reduces Calcitriol getting the mitocondria, this study finds it reduces Calcidiol to blood
Vitamin D Receptor (VDR) Gene Polymorphisms Modify the Response to Vitamin D Supplementation: A Systematic Review and Meta-Analysis
Nutrients 2022,14,360. https://doi.org/10.3390/ nu14020360
Ricardo Usategui-Martín 1,2,% Daniel-Antonio De Luis-Román3,4A José María Fernández-Gómez Marta Ruiz-Mambrilla 7 and José-Luis Pérez-
IOBA, University of Valladolid, 47011 Valladolid, Spain
Cooperative Health Network for Research (RETICS), Oftared, National Institute of Health Carlos III, ISCIII, 47011 Madrid, Spain
Department of Endocrinology, Clinical University Hospital, 47002 Valladolid, Spain; dluisro@saludcastillayleon.es
Department of Medicine, Faculty of Medicine, University of Valladolid, 47002 Valladolid, Spain
Instituto de Endocrinología y Nutrición (IENVA), University of Valladolid, 47002 Valladolid, Spain
Department of Cell Biology, Histology and Pharmacology, Faculty of Medicine, University of Valladolid, 47002 Valladolid, Spain; josefg@med.uva.es
Department of Surgery, Faculty of Medicine, University of Valladolid, 47002 Valladolid, Spain; martamaria.ruiz@uva.es
Department of Internal Medicine, Río Hortega University Hospital, 47002 Valladolid, Spain
- Correspondence: ricardo.usategui@uva.es (R.U.-M.); joseluis.perez@uva.es (J.-L.P.-C.)
The vitamin D receptor (VDR), a member of the nuclear receptor superfamily of transcriptional regulators, is crucial to calcitriol signalling. VDR is regulated by genetic and environmental factors and it is hypothesised that the response to vitamin D supplementation could be modulated by genetic variants in the VDR gene. The best studied polymorphisms in the VDR gene are Apal (rs7975232), BsmI (rs1544410), Taql (rs731236) and Fokl (rs10735810). We conducted a systematic review and meta-analysis to evaluate the response to vitamin D supplementation according to the BsmI, TaqI, ApaI and FokI polymorphisms. We included studies that analysed the relationship between the response to vitamin D supplementation and the genotypic distribution of these polymorphisms. We included eight studies that enrolled 1038 subjects. The results showed no significant association with the BsmI and ApaI polymorphisms (p = 0.081 and p = 0.63) and that the variant allele (Tt+tt) of the TaqI polymorphism and the FF genotype of the FokI variant were associated with a better response to vitamin D supplementation (p = 0.02 and p < 0.001).
In conclusion, the TaqI and FokI polymorphisms could play a role in the modulation of the response to vitamin D supplementation, as they are associated with a better response to supplementation.
VitaminDWiki - The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019__
VDR can be activated
Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators
VitaminDWiki - Resveratrol improves health (Vitamin D receptor, etc.) - many studies has:
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VitaminDWiki - Vitamin D Receptor category has:
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