Genetics

articles in the Genetics category

see also

• Vitamin D Receptor has items

• Vitamin D Binding Protein = GC has items

• CYP27B1 has items

• CYP24A1 in title of 39+ items

• CYP2R1 25+ items

• Calcidiol has items

• Calcitriol has items

• Topical Vitamin D

• Nanoemulsion Vitamin D may be a substantially better form

• 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019

• CYP3A4 (7 as of Dec 2022)

• Glutathione improves the activation of 6 Vitamin D genes - the most known as of May 2025

• Getting Vitamin D into your blood and cells

• 

  Vitamin D blood test misses a lot

• Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%

• Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells

• A Vitamin D test in cells rather than blood was feasible (2017 personal communication)   Commercially available 2019

  • However, test results would vary in each tissue due to multiple genes

• Good clues that Vitamin D is being restricted from getting to the cells

  • 1) A vitamin D-related health problem runs in the family
  •       especially if it is one of 51+ diseases related to Vitamin D Receptor
  • 2) Slightly increasing Vitamin D shows benefits (even if the conventional Vitamin D test shows an increase)
  • 3) DNA and VDR tests - 100 to 200 dollars $100 to $250
  • 4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
  •      Genes are good, have enough Magnesium, etc.
  • 5) Back Pain
  •      probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
    • The founder of VitaminDWiki took action with clues #3&5

Many reasons for the decrease in Vitamin D getting to blood and cells

Click on chart for details

Gene	1. of pages	Location
CYP27A1	449 (Sept 2019)	Liver
* CYP2R1	826 (Sept 2019)	Liver & Tissue
CYP27B1	1430   (Sept 2019)	Kidney & Tissue
CYP24A1	28 in title - May 2022]	excrete excess

• Vitamins regulate some human genes – Feb 2020

• The genetics of vitamin D – Oct 2018

• Does survival of the less fit mean less health (poor genes may be inherited)

  • genes getting worse over generations

• 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019

• Vitamin D deficiency is associated with 35 genes, only 7 of are commercially tested – Nov 2019

Sample of studies

• Vitamin D genes – Review June 2022

• Vitamin D effects on over 300 genes varies with genetics and levels – Dec 2020

• Vitamin D genes are important, update – Sept 2020

• Low Vitamin D in blood is associated with 69 genes, only 6 of which are reported on - Feb 2020

• Does survival of the less fit mean less health (poor genes may be inherited)

• 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019

• Vitamin D affects at least 3,023 DNA locations – July 2018

• 2,776 vitamin D receptor binding sites - April 2014

• 5839 genes changed during pregnancy (many genes were related to Vitamin D) – Oct 2016

• Genes which regulate active vitamin D worsen with age – Oct 2016

• Health problems that run in families are often associated with low vitamin D

• Genes and Vitamin D – literature review – Dec 2015

CYP450 family includes CYP24 and CYP3A

The first chart on this page until Oct 2017 had been

The following chart triggered the creation of the chart at the top of this page

• 

Note the assumption, which may be correct, that the immune system only responds to tissue Vitamin D, rather than from blood vitamin D

• DHCR7 190 hits Oct 2017: make Vit D from the sun

• epigenome OR epigenetics 149 items March 2017

• Telomere 115 items as of March 2017

  •      Note: Epigenetics proven to last for 3 generations in humans and 70 generations in other animals
  •             Wired.com March 2015: Excerpt from new book "Evolving Ourselves"
  •      Note also: 100X more non-human genes are passed on from mother to infant

• All items in category Antibiotics/Probiotics and Vitamin D items

  Immune modulation by Vitamin D, food allergy, chart of genes – July 2015 has the following chart

Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014 is an example of massive gene changes

        shaded text and numbers in the chart were added by VitaminDWiki

Most-visited 10 pages in Genetics category

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Genes on the web

• The Genes That Never Go Out of Style Sept 2018

  • about 16% of all genes were known by 1991; that same 16% are the focus of half of all Genetics papers in 2015
  • 25% of all genes have never been the focus of a single scientific paper
  • "Even supposedly game-changing techniques like CRISPR have altered the landscape of gene popularity very little"

  Short URL= is.gd/vitdgenes