Colorectal Cancer 10 percent more likely if poor Vitamin D Receptor – meta-analysis
Association of vitamin D receptor polymorphisms with colorectal cancer susceptibility: A systematic meta-analysis
Medicine 102(1):p e32575, January 06, 2023. | DOI: 10.1097/MD.0000000000032575
Yang, Maoquan MSa,b; Ji, Wansheng PhDa,c; Xu, Ning MSb; zong, Chuanju MSb; Gu, Jinhua MSb; Guo, Xiaojing MSb; Zhang, Li MSa,*
Background:
Recent studies have reported an association between vitamin D receptor (VDR) polymorphisms and colorectal cancer (CRC) risk; however, the results are controversial. This meta-analysis was performed to investigate whether the Cdx-2, Tru9I, FokI, BsmI, TaqI, and ApaI polymorphisms were correlated with CRC susceptibility.
Methods:
All potential studies were retrieved by searching the PubMed, EMBASE, and Cochrane Library databases through October 2, 2021. Odds ratios (ORs) with 95% confidence intervals were used to evaluate the correlation between VDR gene Cdx-2, Tru9I, FokI, BsmI, TaqI, and ApaI polymorphisms and CRC risk.
Results:
In this meta-analysis, the BsmI variant was significantly correlated with a lower risk of CRC, especially in Caucasian population (
B vs b: OR 0.94, 95%CI 0.90–0.99;
BB vs bb: OR 0.88; 95%CI 0.79–0.97;
BB vs Bb/bb: OR 0.89; 95%CI 0.81–0.98).
A statistically significant result from the FokI polymorphism was observed in colon cancer rather than rectal cancer(
Ff vs FF: OR 0.86, 95%CI 0.84–0.93;
ff/Ff vs FF: OR 0.88, 95%CI 0.79–0.98;
ff vs Ff/FF: OR 0.90, 95%CI 0.82–0.99).
Similarly, Cdx-2 polymorphism was found to be associated with decreased CRC risk among Africans (C vs c: OR 0.50, 95%CI 0.33–0.75; CC vs cc: OR 0.09, 95%CI 0.01–0.77; Cc vs cc: OR 0.49, 95%CI 0.30–0.81; CC/Cc vs cc: OR 0.45, 95%CI 0.28–0.74,).
Conclusion:
Our findings indicate that VDR polymorphisms are significantly associated with CRC risk.
VitaminDWiki - studies in both categories Colon Cancer and Vitamin D Receptor
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VitaminDWiki – Cancer - Colon category contains
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VitaminDWiki - Vitamin D Receptor activation can be increased in 14 ways
Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Butyrate Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 14 known VDR activators
81+ VitaminDWiki VDR pages with CANCER in the title
Note:.Many Cancers protect themselves by deactivating the VDR
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