11 cancers fought by Vitamin D - mini review
The impact of vitamin D on cancer: A mini review
The Journal of Steroid Biochemistry and Molecular Biology. Volume 231, July 2023, https://doi.org/10.1016/j.jsbmb.2023.106308
Gerbenn Seraphin a, Sandra Rieger a b, Martin Hewison c, Enrico Capobianco d, Thomas S. Lisse a b e
Highlights
Vitamin D cancer research has increased substantially in recent years.
Vitamin D continues to show positive anti-cancer effects against many types of cancer.
Demographic studies recommend vitamin D supplementation to prevent cancer.
Vitamin D modulates immunological function, anti-metastasis, and tumorigenesis, according to mechanistic research.
In this review, we summarize the most recent advances in vitamin D cancer research to provide molecular clarity, as well as its translational trajectory across the cancer landscape. Vitamin D is well known for its role in regulating mineral homeostasis; however, vitamin D deficiency has also been linked to the development and progression of a number of cancer types. Recent epigenomic, transcriptomic, and proteomic studies have revealed novel vitamin D-mediated biological mechanisms that regulate cancer cell self-renewal, differentiation, proliferation, transformation, and death. Tumor microenvironmental studies have also revealed dynamic relationships between the immune system and vitamin D's anti-neoplastic properties. These findings help to explain the large number of population-based studies that show clinicopathological correlations between circulating vitamin D levels and risk of cancer development and death. The majority of evidence suggests that low circulating vitamin D levels are associated with an increased risk of cancers, whereas supplementation alone or in combination with other chemo/immunotherapeutic drugs may improve clinical outcomes even further. These promising results still necessitate further research and development into novel approaches that target vitamin D signaling and metabolic systems to improve cancer outcomes.
📄 Download the PDF from VitaminDWiki
16 Major Cancers in VitaminDWiki (April 2023)
After diagnosis (97+)
Bladder (25+)
Bone (8+)
Gastric (9+)
Leukemia (18+)
Liver (16+)
Lymphoma (23+)
Melanoma (43+)
Multiple Myeloma (10+)
Metastatic (17+)
Other (59+) - many minor cancers also fought
Ovarian (23+)
Pallitive Care (10+)
Pancreatic (54+)
Thyroid (7+)
See also: Overview Cancer and vitamin D, Cancer and Vitamin D - many studies
88+ Vitamin D Receptor pages with CANCER etc. in the VitaminDWiki title
Many cancers protect themselves by deactivating the VDR
This list is automatically updated
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