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Low vitamin D associated with all-cause mortality and frailty – Mar 2011

Vitamin D and aging: Beyond calcium and bone metabolism

* Faustino R. Pérez-López
Department of Obstetrics and Gynecology, Universidad de Zaragoza, Facultad de Medicina, Hospital Clínico, Zaragoza 50009, Spain
Received 4 February 2011; accepted 9 February 2011. published online 08 March 2011.
Maturitas; European Menopause Journal

Background
Low serum 25-hydroxyvitamin D (25OHD) levels are common and may be associated with morbidity and mortality (and indeed with frailty more generally). This association is not restricted to the links between vitamin D and calcium and bone metabolism.

Objective
To review the influences of vitamin D on the aging process other than those related to bone and calcium. Its effect on mortality is also assessed.

Methods
The PubMed database was searched for English-language articles relating to vitamin D, using the following MeSH terms: vitamin D, mortality, cardiovascular diseases, and frailty. In addition, searches were carried out with Google.

Results
Although some of the reported results have proved controversial, overall the evidence seems to support an association between low serum 25OHD levels and mortality rates (all-cause and cardiovascular). Frailty is a condition frequently associated with low serum 25OHD levels.

Conclusion
The aging process and mortality are associated with low vitamin D levels. Prospective controlled trials are warranted to determine whether vitamin D supplements can increase longevity and reduce the incidence of certain conditions.

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