Vitamin D and aging: Beyond calcium and bone metabolism
* Faustino R. Pérez-López
Department of Obstetrics and Gynecology, Universidad de Zaragoza, Facultad de Medicina, Hospital Clínico, Zaragoza 50009, Spain
Received 4 February 2011; accepted 9 February 2011. published online 08 March 2011.
Maturitas; European Menopause Journal
Low serum 25-hydroxyvitamin D (25OHD) levels are common and may be associated with morbidity and mortality (and indeed with frailty more generally). This association is not restricted to the links between vitamin D and calcium and bone metabolism.
To review the influences of vitamin D on the aging process other than those related to bone and calcium. Its effect on mortality is also assessed.
The PubMed database was searched for English-language articles relating to vitamin D, using the following MeSH terms: vitamin D, mortality, cardiovascular diseases, and frailty. In addition, searches were carried out with Google.
Although some of the reported results have proved controversial, overall the evidence seems to support an association between low serum 25OHD levels and mortality rates (all-cause and cardiovascular). Frailty is a condition frequently associated with low serum 25OHD levels.
The aging process and mortality are associated with low vitamin D levels. Prospective controlled trials are warranted to determine whether vitamin D supplements can increase longevity and reduce the incidence of certain conditions.
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See also VitaminDWiki
- Overview Seniors lack Vitamin D
- Overview: Bone fractures and vitamin D
- All items in mortality and vitamin D 97 items
- Less than 30 ng vitamin D greatly increased hazard of dying and diabetes – Nov 2010
- Cardiovascular Disease Risk Factors and Markers (Session Title)
- All cause mortality and vitamin D - Feb 2011.pdf file
- You are 66 percent more likely to die if low vitamin D – CDC Jan 2010
- Critically ill 70 percent more likely to die if vitamin D less than 15ng – Jan 2011
- Vitamin D deficiency was the best predictor of older patient death in hospital – May 2010
- Heart patients 10 percent more likely to die for every 4 ng less vitamin D – May 2011