Overview Toxicity of vitamin D

Graph of dose vs week


  • Thus the following are safe:
    2 million IU daily for 1 week,
    200,000 IU daily for 1.5 weeks,
    150,000 IU daily for 2 weeks,
    85,000 IU daily for 4 weeks,
    50,000 IU daily for 5 weeks
  • The toxicity reports are generally for Vitamin D monotherapy - at about 2 million IU total dose
  • Magnesium, Vitamin K2, and other COFACTORS will move the curve to the right
  • Also you need to reduce Calcium when having lots of vitamin D
  • True toxicity (with cofactors) is probably much higher than the monotherapy line on the chart

In most cases a doctor will just let the body remove any toxic amount of vitamin D by itself

  • Vitamin D DOES NOT accumulate in the body WikiPedia on Bioaccumulation
  • No medical procedure is needed. The body deals with the excess naturally

at very high levels the half-life of vitamin D is measured in days contains the following graphic
see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=3133

Toxicity of Vitamin D

From the web

  • 85,000 IU daily for 13 weeks - toxic for 67 year old woman
  • Injections of 15,000,000 IU of vitamin D and 60,000,000 vitamin A caused swelling full text on-line
    The swelling is what the patient wanted - the swelling looked like bigger muscles
  • 40,000 IU vitamin D daily was OK for 28 weeks - small MS study reported by Cochrane in 2010 mention by Vitamin D Council Oct 2012
  • How Much Vitamin D is Too Much? The Surprising Truth Sept 2015?
    Nice overview - here are some of the conclusions
    "Bottom Line: Blood levels in the range of 20–30 ng/ml are usually considered sufficient. The safe upper limit is considered to be about 60 ng/ml, but people with symptoms of toxicity usually have levels above 150 ng/ml."
    "Bottom Line: The safe upper limit of intake is set at 4000 IU/day. Intake in the range of 40,000–100,000 IU/day (10-25 times the recommended upper limit) has been linked with toxicity in humans."
    "Bottom Line: If you are supplementing with vitamin D, then it may be important to also ensure sufficient intake of vitamin A, vitamin K and magnesium. These may reduce the risk of adverse effects from a higher vitamin D intake."

Institute of Medicine said in Nov 2010 that 4,000 IU is OK (upper limit of OK)

Graph of RDA and Upper Limit
IoM again fails to look at interactions - Nov 2010
Beware getting too much Calcium if taking more than 2,000 IU of vitamin D,

Many studies have shown: No toxicity <30,000 IU, <200 ng


Short url = http://is.gd/toxicvd

Page visited 24210 times. Last modified 10 September, 2015 . URL:
Print Printer Friendly PDF PDF this page! Follow this page for updates Follow this page for updates.

See any problem with this page? Report it to the webmaster.