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Overview MS and vitamin D


Strong evidence: Vitamin D PREVENTS MS and REDUCES MS symptoms
- Clinical trials for MS and Vitamin D INTERVENTION 25 as of Feb 2014
-     5,000 IU daily for 2 years   7,000 IU avg  10,000 IU
- Multiple Sclerosis prevention by Vitamin D: 10 year, 30 million dollar trial - Sept 2013
- Vitamin D being used for MS more than any other disease
- 3 books with sections on MS and vitamin D
- Vitamin D found to be far better than FDA drug for MS
- Many MS websites are very pro vitamin D
- People at risk of having low vitamin D (elderly, women, blacks,...) have greater incidence of MS
- Multiple Sclerosis: number needed to treat with vitamin D may be as low as 1.3 – Meta-analysis Oct 2013
- 98 pcnt of genes that Vitamin D activates to reduce MS are also activated by Interferon -May 2013
- Autoimmune disorder patients in Brazil helped by vitamin D – video and Facebook – Nov 2012 extremely successful - using 20,000 - 140,000 IU daily
- Appears that Vitamin D can induce remission in recent Multiple Sclerosis with before/after MRI brain scans
- Controversy: Which is better: UV or Vitamin D

There is a growing mountain of evidence that vitamin D prevents MS

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It has been known for a long time that MS varies with latitude.

  • CLICK HERE to see the whole journal article from Lancet June 2010

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Increased MS for those with less vitamin D - summary of studies from 2009

from PDF in MS Category

However, there has been a decrease in the association of MS with latitude during the 20th century in the US

Probably due to air conditioning being used in the Southern part of the US
Shows decrease of association of MS with latitude during 2oth century wars - probably due to people in the South being able to be indoors due to air conditioning

People with a high level of vitamin D have far less MS and many other diseases

derived from Grassroots 2013

Patients like me web site shows that Vitamin D is used by more people with MS than any other specific disease

Mega Doses of Vitamin D for MS PatientsLikeMe Oct 2012 9,000 messages on forum
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Vitamin D at CureTogether: Fibromyalgia, MS, Psorasis, etc - Dec 2013

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MS entry in WikiPedia concerning vitamin D

Decreased sunlight exposure has been linked with a higher risk of MS.
Decreased vitamin D production and intake has been the main biological mechanism used to explain the higher risk among those less exposed to sun.

The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability.

The life expectancy of people with MS is 5 to 10 years lower than that of unaffected people. Almost 40% of patients reach the seventh decade of life.
Although most patients lose the ability to walk prior to death, 90% are still capable of independent walking at 10 years from onset, and 75% at 15 years.

There is a north-to-south gradient in the northern hemisphere and a south-to-north gradient in the southern hemisphere, with MS being much less common in people living near the equator. Climate, sunlight and intake of vitamin D have been investigated as possible causes of the disease that could explain this latitude gradient. However, there are important exceptions to the north-south pattern and changes in prevalence rates over time; in general, this trend might be disappearing.

Books with large sections on MS and Vitamin D include

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  • Vitamin D3 and Solar Power by Dr. Sorenson has 9 pages of MS and vitamin D
  • Sunshine and Vitamin D by Frank Murray has 7 pages on MS and vitamin D
  • Multiple Sclerosis (The Facts) 17 references to Vitamin D Publication Date Oct 2012
    $20.00, 96 pages

All vitamin D books at VitaminDWiki including the above

MS trust has a good fact sheet on vitamin D - Feb 2010.pdf

See in VitaminDWiki

See also MS on the web


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African Americans have a worse time with MS

M Obama's father was another African American with MS living in the North. suspect he was very low on vitamin D

from 2008 speech: My Dad was our rock. Although he was diagnosed with Multiple Sclerosis in his early thirties, he was our provider, our champion, our hero. As he got sicker, it got harder for him to walk, it took him longer to get dressed in the morning. But if he was in pain, he never let on. He never stopped smiling and laughing - even while struggling to button his shirt, even while using two canes to get himself across the room to give my Mom a kiss. He just woke up a little earlier, and worked a little harder.

Montel Williams has MS, has funded MS research, and is a big proponent of marijuana to reduce intensity of MS

Interesting to note that Google gets 70,000 hits for +"Multiple sclerosis" +"vitamin d" +marijuana.

Perhaps vitamin D is as good or better treatment for MS than marijuana

Have been unable to contact the Montel Williams MS organization - their phone is disconnected
Update 2012: Montell Williams was apparently on Oprah show and agreed that Vitamin D helped MS


FACT: At least some MS is associated with a gene variant

FACT: People with MS need higher levels of vitamin D to treat the symptoms

SPECULATION: Those people with the gene variant need higher levels of vitamin D in the blood to prevent/treat MS

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vitamin D directly terminates the production of a disease-causing protein Summary article from Medical News today Aug 2011

clip from Medical News:
"According to the researchers, the mechanism they identify suggests what might be a new path toward pharmaceutical treatment of MS, as well as therapies for other autoimmune diseases that might include rheumatoid arthritis, type 1 diabetes, eczema and psoriasis."

The abstract

1,25-Dihydroxyvitamin D3 Ameliorates Th17 Autoimmunity via Transcriptional Modulation of Interleukin-17A.

Mol Cell Biol. 2011 Sep;31(17):3653-69. Epub 2011 Jul 11.
Joshi S, Pantalena LC, Liu XK, Gaffen SL, Liu H, Rohowsky-Kochan C, Ichiyama K, Yoshimura A, Steinman L, Christakos S, Youssef S.
UMDNJ-New Jersey Medical School, Department of Biochemistry and Molecular Biology, 185 South Orange Ave., E609, Newark, NJ 07103. christak at umdnj.edu.

A new class of inflammatory CD4(+) T cells that produce interleukin-17 (IL-17) (termed Th17) has been identified, which plays a critical role in numerous inflammatory conditions and autoimmune diseases. The active form of vitamin D, 1,25-dihydroxyvitamin D(3) 1,25(OH)(2)D(3), has a direct repressive effect on the expression of IL-17A in both human and mouse T cells. In vivo treatment of mice with ongoing experimental autoimmune encephalomyelitis (EAE; a mouse model of multiple sclerosis) diminishes paralysis and progression of the disease and reduces IL-17A-secreting CD4(+) T cells in the periphery and central nervous system (CNS). The mechanism of 1,25(OH)(2)D(3) repression of IL-17A expression was found to be transcriptional repression, mediated by the vitamin D receptor (VDR). Transcription assays, gel shifting, and chromatin immunoprecipitation (ChIP) assays indicate that the negative effect of 1,25(OH)(2)D(3) on IL-17A involves blocking of nuclear factor for activated T cells (NFAT), recruitment of histone deacetylase (HDAC), sequestration of Runt-related transcription factor 1 (Runx1) by 1,25(OH)(2)D(3)/VDR, and a direct effect of 1,25(OH)(2)D(3) on induction of Foxp3. Our results describe novel mechanisms and new concepts with regard to vitamin D and the immune system and suggest therapeutic targets for the control of autoimmune diseases.

PMID: 21746882

Christakos S, has co-authored many vitamin D papers, such as:

Vitamin D and MS ORG excellent


MS is in a vicious cycle with vitamin D: low D ==> MS which lowers vitamin D

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CLICK HERE for more about deficiencies and vicious cycles

short url = http://is.gd/msvitd


Page last modified on 16 March, 2014


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List of attached files
ID Name desc uploaded Size Downloads Actions
1618 pdf UV better than vitamin D for autoimmune - 2009.pdf PDF 24 Sep., 2012 by admin 463.30 Kb 352 View Download  
908 png MS vicious cycle.png 01 Dec, 2011 by admin 19.39 Kb 4304 View Download  
643 jpg ms and genetics.jpg 18 July, 2011 by admin 21.63 Kb 3792 View Download  
292 jpg MS down staircase.jpg MS progress down 11 Nov., 2010 by admin 49.60 Kb 5371 View Download  
130 gif MS Clinical trials - Aug 2010.gif MS Clinical trials - Aug 2010 03 Aug., 2010 by admin 42.01 Kb 2115 View Download  
129 gif MS wikipedia.gif MS wikipedia 03 Aug., 2010 by admin 17.57 Kb 829 View Download  

Number of pages on VitaminDWiki = 4895


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{#s as of April 10, 2014}