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Overview Liver and vitamin D


Fact: A properly functioning liver is needed for the efficient activation of vitamin D in the body
Fact: Liver diseases often result in lower levels of vitamin D
Fact: Various pain relievers damage the liver function
Fact: Lower levels of vitamin D result in osteoporosis and many other diseases
Options with a poorly functioning liver appear to be:

  1. Increased vitamin D (example: 2X more vitamin D if Liver is 1/2 as efficient)
  2. Increase the response you get from vitamin D
  3. Increase sunshine / UVB,
  4. Get the response you get from the sun/UVB
  5. Consider supplementing with Iron - a patented Iron supplement appears to work very well
  6. Get prescription for active form of vitamin D (Calcitriol) which does not need the liver to get the benefits of vitamin D in the body
  7. Get Calcidiol which also does not need the liver

http://vitamindwiki.com/tiki-index.php?page_id=5644
Click on image for ways of getting vitamin D even if Liver is not functioning well

See also VitaminDWiki



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Inflammatory diseases: review of vitamin D, with many tables – May 2014 which has a summary table
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Most of the people with the diseases have less than 20 ng of vitamin D

See also Web


Chronic Liver Diseases might be treated by Vitamin D - Dec 2014

New insight of vitamin D in chronic liver diseases
Hepatobiliary Pancreat Dis Int. 2014 Dec;13(6):580-5. PMID: 25475859
Chen EQ1, Shi Y, Tang H.

CONCLUSIONS:
Although the exact role and mechanisms of vitamin D have not been fully elucidated in chronic liver diseases,
it is potentially beneficial in the treatment of chronic liver diseases.
Further mechanistic studies are needed to validate its clinical application.
 Download the PDF from VitaminDWiki.


Low vitamin D = 2X worse liver cancer prognosis

Severe 25-hydroxyvitamin D deficiency identifies a poor prognosis in patients with hepatocellular carcinoma - a prospective cohort study.
Aliment Pharmacol Ther. 2014 May;39(10):1204-12. doi: 10.1111/apt.12731. Epub 2014 Mar 29.
Finkelmeier F1, Kronenberger B, Köberle V, Bojunga J, Zeuzem S, Trojan J, Piiper A, Waidmann O.

BACKGROUND: Vitamin D is involved in many biological processes. The role of vitamin D in patients with hepatocellular carcinoma (HCC) remains inconclusive, although there is evolving evidence that vitamin D may modulate cancer development and progression.

AIM: To evaluate serum vitamin D as prognostic parameter in HCC, we performed a prospective cohort study.

METHODS: HCC patients were prospectively recruited and 25-hydroxyvitamin D3 (25(OH)D3 ) levels were determined. 25(OH)D3 levels were compared to stages of cirrhosis and HCC stages with nonparametric Kruskal-Wallis tests and Spearman correlations in 200 HCC patients. The association of the 25(OH)D3 levels and overall survival (OS) was assessed in uni- and multivariate Cox regression models.

RESULTS: Two-hundred patients with HCC were included. The mean follow-up time was 322 ± 342 days with a range of 1-1508 days. Nineteen patients underwent liver transplantation and 60 patients died within the observation time. The mean serum 25(OH)D3 concentration was 17 ± 13 ng/mL with a range of 1-72 ng/mL. 25(OH)D3 serum levels negatively correlated with the stage of cirrhosis as well as with stages of HCC. Patients with severe 25(OH)D3 deficiency had the highest mortality risk (hazard ratio 2.225, 95% confidence interval 1.331-3.719, P = 0.002). Furthermore, very low 25(OH)D3 levels were associated with mortality independently from the MELD score and high alpha-Fetoprotein levels (>400 ng/mL) in a multivariate Cox regression model.

CONCLUSIONS: We conclude that 25(OH)D3 deficiency is associated with advanced stages of hepatocellular carcinoma and it is a prognostic indicator for a poor outcome.

© 2014 John Wiley & Sons Ltd.

Comment in
Commentary: vitamin D deficiency and liver cancer - cause, effect or myth? Authors' reply. [Aliment Pharmacol Ther. 2014]
Commentary: vitamin D deficiency and liver cancer - cause, effect or myth? [Aliment Pharmacol Ther. 2014]
PMID: 24684435
Can rent PDF from publisher for $6





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