The effect of hypervitaminosis D and intoxication on haematological parameters hemogram parameters in patients with very high vitamin D levels
Minerva Endocrinol (Torino) . 2021 Nov 26. doi: 10.23736/S2724-6507.21.03614-9
Adnan Batman 1, Rafiye Ciftciler 2
Background: This study aims to compare the haematological parameters of patients with very high and normal 25-hydroxyvitamin-D3 (25(OH)D3) levels.
Methods: This study was designed as a retrospective cross-sectional study. The patients were divided into three groups according to their 25(OH)D3 levels: groups 1, 2, and 3 are patients with normal 25(OH)D3 levels (30-88 ng/mL), hypervitaminosis D (89-149 ng/mL) and vitamin D intoxication (>150 ng/mL), respectively. According to vitamin D levels, statistical analysis was performed by comparing the biochemical and haematological data between the groups.
Results: This study evaluated 120 patients (40 patients) in three equal groups. A statistically significant difference was found between the three groups in haemoglobin (p = 0.03), haematocrit (p = 0.01), red blood cell levels (p = 0.03), leukocyte count (p < 0.001), neutrophil count (p < 0.001), lymphocyte count (p = 0.006), mean platelet volume (p = 0.04), and neutrophil/lymphocyte ratio (p = 0.03).
In post hoc analysis,
- haemoglobin,
- haematocrit and
- RBC
were significantly higher in group 1 than in group 3 (post hoc Tukey, p < 0.05). A statistically significant negative correlation was noted between 25(OH)D3 level and haemoglobin (r = -0.236), haemotocrit (r = -0.230), and red blood cell (r = -0.265) levels.
Conclusions: Vitamin D intoxication has been observed to affect haemoglobin, haematocrit, and RBC levels negatively. However, more studies are needed to clarify the effects and mechanisms of high vitamin D levels on the haematopoietic system.
When Vitamin D levels are >150 ng, Iron might be needed
The founder of VitaminDWiki has had Vitamin D level >200 ng since 2018
has adjusted cofactors, and is taking 1 Iron pill a week
2021 blood work was all in a normal range (except for the Vitamin D level)
Anemia is assocated with both very low and very high vitamin D (Mexican seniors) – Oct 2021
Vitamin D Cofactors in a nutshell table show the importance of each
Supplement | # of studies | Increase D to tissue | How Often | ||
Magnesium | 349 | Many people need Mg Vit D consumes Mg Muscle pain, Afib | 30% | Several times a day | |
Vitamin K | 152 | Hard bones, soft arteries | 115% | 2 day | |
Omega-3 | 394 | Synergistic with Vit D Independent of Vit D | 30? % | 2 day | |
Calcium | 220 | Reduce or add Vit K | 2 day | ||
Zinc | 88 | immunity | 20 ?% if poor VDR | 7 day | |
Boron | 37 | plants and animals need B | +20% | 7 day | |
Resveratrol | 47 | antioxidant | >100% if poor VDR | Daily |
Also Vitamin C 54 | Iodine 30 | Iron 68 | Vitamin B12 57 | Selenium 25 | Folate 31 |