Sepsis is 13 X more likely if poor Vitamin D Receptor

Vitamin D receptor gene polymorphisms association with the risk of sepsis and mortality

Inter, J of Immunogenetics, published: 12 April 2017. DOI: 10.1111/iji.12318

K. Zeljic katarina.zeljic@bio.bg.ac.rs, A. Elkilany, G. Supic, M. Surbatovic, D. Djordjevic, Z. Magic, B. Bozic

Funding information The study was financed by the Military Medical Academy Institutional Grant 06/10/A1 and the Serbian Ministry of education, science and technological development (Grant 175033).

Summary

Association of vitamin D receptor (VDR) gene polymorphisms with sepsis risk and mortality was studied. VDR FokI CC genotype was associated with increased sepsis risk (OR = 13.396, p = .000009) compared to the TT genotype. Results suggest possible role of VDR FokI (rs2228570) as a molecular biomarker of increased sepsis risk.

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