Preeclampsia (hypertension while pregnant) varies with season (O.R. 0.57)

Created June 2021

Antenatal Exposure to UV-B Radiation and Preeclampsia: A Retrospective Cohort Study

J Am Heart Assoc . 2021 Jun 22;e020246. doi: 10.1161/JAHA.120.020246

Claire E Hastie 1, Daniel F Mackay 1, Tom L Clemens 2, Mark P C Cherrie 2, Lauren J Megaw 3, Gordon C S Smith 4, Sarah J Stock 5, Chris Dibben 6, Jill P Pell 1

Comment This study recommends decreasing preeclampsia by adding UVB in low seasons The following studies indicate that adding vitamin D and vitamin D Receptor activators might be much easier and more effective Items in both categories Pregnancy and Hypertension are listed here: {category} --- 1. Hypertension category listing contains the following {include} --- The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019 * Omega-3,  Magnesium, Zinc,  Quercetin,  non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc**  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators --- Pregnancy category starts with {include} Healthy pregnancies need lots of vitamin D has the following summary {include}

Background Risk of preeclampsia varies by month of delivery. We tested whether this seasonal patterning may be mediated through maternal vitamin D concentration using antenatal exposure to UV-B radiation as an instrumental variable.

Methods and Results Scottish maternity records were linked to antenatal UV-B exposure derived from satellites between 2000 and 2010. Logistic regression analyses were used to explore the association between UV-B and preeclampsia, adjusting for the potential confounding effects of month of conception, child's sex, gestation, parity, and mean monthly temperature. Of the 522 896 eligible singleton deliveries, 8689 (1.66%) mothers developed preeclampsia. Total antenatal UV-B exposure ranged from 43.18 to 101.11 kJ/m2 and was associated with reduced risk of preeclampsia with evidence of a dose-response relationship (highest quintile of exposure: adjusted odds ratio, 0.57; 95% CI, 0.44-0.72; P<0.001). Associations were demonstrated for UV-B exposure in all 3 trimesters.

Conclusions The seasonal patterning of preeclampsia may be mediated through low maternal vitamin D concentration in winter resulting from low UV-B radiation. Interventional studies are required to determine whether vitamin D supplements or UV-B-emitting light boxes can reduce the seasonal patterning of preeclampsia.

Tags: Hypertension Pregnancy