Pre-mature births reduced 43 percent by Vitamin D – Cochrane review

Vitamin D supplementation for women during pregnancy

Luz Maria De-Regil1, Cristina Palacios2, Lia K Lombardo3, Juan Pablo Peña-Rosas4,*

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 14 JAN 2016, DOI: 10.1002/14651858.CD008873.pub3

1Micronutrient Initiative, Research and Evaluation, Ottawa, ON, Canada

2University of Puerto Rico, Nutrition Program, Department of Human Development, Graduate School of Public Health, San Juan, Puerto Rico

3Indiana University School of Medicine, General Surgery, Indianapolis, Indiana, USA

4World Health Organization, Evidence and Programme Guidance, Department of Nutrition for Health and Development, Geneva, Switzerland

• Juan Pablo Peña-Rosas, Evidence and Programme Guidance, Department of Nutrition for Health and Development, World Health Organization , 20 Avenue Appia, Geneva, 1211, Switzerland. penarosasj@who.int. juanpablopenarosas@outlook.com.

Clipped from the summary

• With respect to infant outcomes, data from three trials involving 477 women suggest that vitamin D supplementation during pregnancy reduces the risk preterm birth compared to no intervention or placebo ( 8.9% versus 15.5%; RR 0.36 ; 95% CI 0.14 to 0.93, moderate quality).

• Data from three trials involving 493 women also suggest that women who receive vitamin D supplements during pregnancy less frequently had a baby with a birthweight below 2500 g than those receiving no intervention or placebo (RR 0.40; 95% CI 0.24 to 0.67, moderate quality).

See VitaminDWiki: Healthy pregnancies need lots of vitamin D

which has the following summary (click on underlined items for details)

{include}

See also VitaminDWiki

• Vitamin D Random Controlled Trials are becoming impossible

• WHO still says mistakenly says NO vitamin D during pregnancy, and only 200 IU after

  • Note the lead author works at the World Health Organization
• Vitamin D deficiency is a major global public health problem – Maps Nov 2013
  • Note: She is a co-author of this Chochran report

• Cochrane review finds that Vitamin D helps prevent fractures– downloaded Feb 2010

• Scalp psoriasis – Vitamin D was a component of every successful topical treatment – Cochrane Feb 2016

• Even small amounts of Vitamin D prevent mortality in adults – Cochrane Review Jan 2014

• Pregnancy – Cochrane review – pure junk - Jan 2016 previous review of report on VitaminDWiki

Cochrane failed to consider trials

1. With daily doses of more than 2,000 IU
   • 2000 IU had been the upper limit in the US
   • 8 trials used < 1000 IU, 6 trials 1000-2000 IU
2. With Vitamin D dosing before week 20
   • thus not documenting the huge benefits when vitamin D is started early

3. With daily dose sizes which varied per person ( vitamin D level, obesity, etc)

4. That gave vitamin D to everyone (control = others)

   • many trials now consider it unethical to not give vitamin D to everyone
5. Of women with Gestational Diabetes
   • Note: 2X decrease in Gestational Diabetes with lots of vitamin D

6. Which used additional supplements – such as Omega-3 or Magnesium

7. Which used loading doses

   • which gives people a good level of vitamin D as soon as possible

   Page 17 shows how little vitamin D was used

📄 Download the Cochrane PDF with VitaminDWiki highlights

Intervention AND Pregnancy trials in VitaminDWiki (most of which are ignored by Cochrane)

{category}