Inflammation of blood vessels (vasculitis): low Vitamin D and 22 X more likely to have kidney problems
Vitamin D levels in patients with small and medium vessel vasculitis
Reumatol Clin (Engl Ed) . 2022 Mar;18(3):141-146. doi: 10.1016/j.reumae.2020.11.004 - behind paywall
Fatma Nur Korkmaz 1, Gulsen Ozen 2, Ali Ugur Unal 3, Asli Odabasi 4, Meryem Can 5, Ebru Asıcıoglu 6, Serhan Tuglular 6, Haner Direskeneli 3
Objectives: To determine the prevalence of vitamin D deficiency in patients with small and medium vessel systemic vasculitis.
Methods: In this cross-sectional study, 25-hydroxy (OH) vitamin D3 levels were measured in adult patients with systemic small and medium vessel vasculitis including antineutrophil cytoplasmic antibody-associated vasculitis (AAV), cryoglobulinaemic vasculitis (CryV), IgA vasculitis (IgAV) and polyarteritis nodosa (PAN), and age- and sex-matched healthy subjects (HS) and patients with rheumatoid arthritis (RA) as control groups. 25OH vitamin D3 levels<30ng/ml and <20ng/ml were regarded as insufficiency and deficiency, respectively.
Results: Fifty-seven patients (42 AAV, 2 CryV, 8 IgA vasculitis, 5 PAN) with systemic vasculitis, 101 HS, and 111 RA patients were included. The mean 25OH vitamin D3 level was
21.8±14.2ng/mL in patients with vasculitis,
42.7±27.6ng/mL in HS (p<.001) and
20.1±18.47ng/mL in patients with RA (p=.54).
Vitamin D insufficiency and deficiency were significantly higher in patients with systemic vasculitis compared to HS (75.4% vs 33.7%, p<.001; %50 vs 21.8%, p<.001, respectively).
Vitamin D status was not different in patients with systemic vasculitis compared to RA. There was a negative correlation between vitamin D status and CRP levels (=-.364, p=.007).
The multivariate logistic regression analysis showed that renal involvement was significantly associated with vitamin D deficiency/insufficiency in patients with vasculitis (OR 22.5 [95% CI 1.6-128.9].
Conclusion: Vitamin D deficiency and insufficiency are more frequent in patients with systemic small and medium vessel vasculitis and RA than HS. Renal involvement is one of the factors associated with vitamin D deficiency/insufficiency in patients with vasculitis.
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Vasculitis on the web
Wikipedia March 2022
"Vasculitis is a group of disorders that destroy blood vessels by inflammation.[2] Both arteries and veins are affected. Lymphangitis (inflammation of lymphatic vessels) is sometimes considered a type of vasculitis.[3] Vasculitis is primarily caused by leukocyte migration and resultant damage. Although both occur in vasculitis, inflammation of veins (phlebitis) or arteries (arteritis) on their own are separate entities."
According to the size of the vessel affected, vasculitis can be classified into:[7][8]
Large vessel: Takayasu's arteritis, Temporal arteritis
Medium vessel: Buerger's disease, Kawasaki disease, Polyarteritis nodosa
Small vessel: Behçet's syndrome, Eosinophilic granulomatosis with polyangiitis, Cutaneous vasculitis, granulomatosis with polyangiitis, Henoch–Schönlein purpura, and microscopic polyangiitis.
Leg Vasculitis
