Cancers are associated with low vitamin D, poor vaccination response and perhaps poor VDR

Serial negative response after standard and third (Booster) dose of COVID-19 inactivated vaccine is associated with low vitamin D levels in patients with solid cancers

Front Med (Lausanne). 2022 Jul doi: 10.3389/fmed.2022.898606. eCollection 2022.

Yifei Ma 1 , Pengfei Zhu 2 , Guanqing Zhong 3 , Dao Wang 4 , Lu Cao 5 , Shenrui Bai 5 , Youlong Wang 6 , Ao Zhang 3 , Xinjia Wang 1 7

Introduction: The response is poorly understood to the third dose in patients with cancer who failed the standard dose of inactivated SARS-CoV-2 vaccines (CoronaVac). We aim to assess the immune response to the third dose and identify whether vitamin D deficiency is associated with serial serologic failure in patients with cancer.

Methods: Solid cancer patients (SCP-N) and healthy controls (HCs) who were seronegative after the standard-dose vaccines in our previous study were prospectively recruited, from October 2021 to February 2022, to receive the third dose vaccines and anti-SARS-CoV-2S antibodies were measured. SCP-N who failed the third dose (serial seronegative group, SSG) were matched by propensity scores with the historical standard-dose positive cancer patient group (robust response group, RRG). An exploratory analysis was carried out to validate the role of vitamin D on the serology response.

Results: The multi-center study recruited 97 SCP-N with 279 positive controls as RRG and 82 negative controls as HC group. The seroconversion rate after third-dose vaccination was higher in SCP-N than in HC (70.6% vs. 29.4%, p < 0.01). The matched comparison showed that patients in SSG had a significantly lower level of vitamin D and consumption rate than RRG or RRG-B (RRG with third-dose positive) (all p < 0.01). None had serious (over grade II) adverse events after the third dose.

Conclusion: Solid cancer patients with second-dose vaccine failure may have a relatively poor humoral response to the third dose of COVID-19 vaccines as compared with the seronegative HC group. The consecutively poor humoral response could be associated with poor vitamin D levels and intake. Vitamin D status and cancer-related immune compromise may jointly affect the humoral response following booster vaccination.

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There is a strong association between a poor VDR and many health problems

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

The Vitamin D Receptor is associated with many health problems

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Diseases associated with a poor Vitamin D Receptor

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VitaminDWiki - Vitamin D Receptor (Cancers OR Viruses) - many studies 78 studies as of Aug 2022

• Poor prognosis of solid childhood cancers 14.7 X more likely with a poor Vitamin D Receptor – July 2022

• Cancers and Vitamin D Receptors, including change with race – Feb 2021

• Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016

• Women with Breast Cancer were 16.9 times more likely to have a poor Vitamin D Receptor – Jan 2019

Sometimes the health problem deactivates the VDR (thus protecting itself from Vitamin D)

• COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021

• Epstein-Barr is yet another virus that deactivates the Vitamin D receptor (COVID later suspected as well)– 2010

• Herpes (Cytomegalovirus) downregulates the vitamin D receptor by 8X – Jan 2017

• Lyme disease and Vitamin D Receptor - many studies

VitaminDWiki - Vaccination in 172 titles as of Aug 2022

• Innate immune suppression by SARS-CoV-2 mRNA vaccinations - April 2022

• COVID vaccination: 29 percent higher antibody response if more than 20 ng of vitamin D – March 2022

• COVID vaccination makes 6X more antibodies in those having good levels of both vitamin D and Iron – June 2021

• COVID, influenza, hepatitis B, measles, etc. vaccine responses vary with Vitamin D and its receptor