Cancers and Vitamin D Receptors, including change with race

Ethnicity as modifier of risk for Vitamin D receptors polymorphisms: Comprehensive meta-analysis of all cancer sites

Critical Reviews in Oncology/Hematology, Vol 158, Feb 2021, 103202 https://doi.org/10.1016/j.critrevonc.2020.103202

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Highlights

• VDR polymorphisms have been found to be associated with some cancer sites.

• Cancer incidence rates vary by ethnicity and genetic factors.

• Fok1, Bsm1, Cdx2, Apa1 and Taq1 polymorphisms are linked to cancer risk.

• Ethnicity may be a modifier of risk in particular for hormone dependent cancers.

Vitamin D receptors polymorphisms are found to be associated with several cancers. Since their prevalence vary across ethnicities and ethnicity itself seems to influence the cancer risk, a comprehensive meta-analysis was performed to investigate the role of VDR Fok1, Bsm1, Taq1, Apa1, Cdx2 and cancer risk at specific organ sites. Odds ratios, calculated with random-effects models, summarized one-hundred-ninety-two independent studies for twenty-two cancer sites.

Evidence was provided that Fok1, Bsm1, Cdx2, Apa1 and Taq1 are linked to cancer susceptibility for colorectal, lung, ovarian, skin, multiple myeloma and brain cancer. Stratifying by ethnicity, some differences were found, partially explained by minor allele frequency (MAF), for colorectal cancer, ovarian and prostate cancer in Caucasian and prostate cancer in Asian populations. In summary, ethnicity may be a modifier of cancer risk, in particular for hormone dependent cancers and it should be considered evaluating the effect of VDR on cancer risk.

Vitamin D Receptor pages with CANCER in title

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Vitamin D RECEPTOR pages with DARK SKIN or RACE in title

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Vitamin D Receptor category has the following__

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VDR by type of Cancer

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Resveratrol improves health (Vitamin D receptor, etc.) - many studies

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