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Suicide associated with low vitamin D

Association between suicide and low vitamin D include:

  1. Suicide peaks in the Spring, when vitamin D values are lowest
  2. Suicide has increasing while vitamin D has been decreasing
  3. Suicide higher in some dark skinned people (Who have low vitamin D due to built-in sun protection)
  4. Suicide higher in prision (shut-ins have low levels of vitamin D)
  5. Suicide rate is higher at high latitudes (where vitamin D is less available)
    See Criteria to associate a health problem with low vitamin D

People who attempted suicide were vitamin D deficient – Dec 2014

Suicidal patients are deficient in vitamin D, associated with a pro-inflammatory status in the blood
Psychoneuroendocrinology, Volume 50, December 2014, Pages 210–219
Cécile Grudet a cecile.grudet at med.lu.se. Johan Malm b, Åsa Westrin a, c, Lena Brundin d, e
a Department of Clinical Sciences, Lund, Psychiatry, Lund University, 221 85 Lund, Sweden
b Department of Laboratory Medicine, Section for Clinical Chemistry, Malmö, Lund University, 205 02 Malmö, Sweden
c Psychiatric Clinic, Lund, Region Skåne, Sweden
d Department of Psychiatry and Behavioral Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA
e Laboratory for Behavioral Medicine, Van Andel Research Institute, Grand Rapids, MI, USA


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Background
Low levels of vitamin D may play a role in psychiatric disorders, as cross-sectional studies show an association between vitamin D deficiency and depression, schizophrenia and psychotic symptoms. The underlying mechanisms are not well understood, although vitamin D is known to influence the immune system to promote a T helper (Th)-2 phenotype. At the same time, increased inflammation might be of importance in the pathophysiology of depression and suicide. We therefore hypothesized that suicidal patients would be deficient in vitamin D, which could be responsible for the inflammatory changes observed in these patients.

Methods
We compared vitamin D levels in suicide attempters (n = 59), non-suicidal depressed patients (n = 17) and healthy controls (n = 14). Subjects were diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, and went through a structured interview by a specialist in psychiatry. 25(OH)D2 and 25(OH)D3 were measured in plasma using liquid-chromatography–mass-spectrometry (LC–MS). We further explored vitamin D's association with plasma IL-1β, IL-6 and TNF-α.

Results
Suicide attempters had significantly lower mean levels of vitamin D than depressed non-suicidal patients and healthy controls. 58 percent of the suicide attempters were vitamin D deficient according to clinical standard. Moreover, there was a significant negative association between vitamin D and pro-inflammatory cytokines in the psychiatric patients. Low vitamin D levels were associated with higher levels of the inflammatory cytokines IL-6 and IL-1β in the blood.

Conclusion
The suicide attempters in our study were deficient in vitamin D. Our data also suggest that vitamin D deficiency could be a contributing factor to the elevated pro-inflammatory cytokines previously reported in suicidal patients. We propose that routine clinical testing of vitamin D levels could be beneficial in patients with suicidal symptoms, with subsequent supplementation in patients found to be deficient.

 Download the PDF from VitaminDWiki.


See also VitaminDWiki

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Suicide increasing and is now the top cause of death of adults

Suicide has become the top cause of death for adults (15-49) around the world
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Suicides increasing over the years, and peak in the Spring

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No, Suicides Don't Rise During the Holidays Dec 2015
Pollen suspected, Vitamin D not mentioned


Suicide infographic

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See also web - Vitamin D

See also web - Cholesterol

  • Serum lipid levels and suicidality: a meta-analysis of 65 epidemiological studies Jan 2016
    123% higher risk of suicide attempt - from 510,392 people
    No such attachment on this page
  • Review of above study by Dr. Grimes, Dec 2016
    "A comment from the authors, but not an observation from the study:"
    “an increasing number of reports raise the possibility that statins, a class of lipid-lowering agents, may be associated with deleterious cognitive, mood and behavioural adverse effects, including violence, depression and suicide, which have been attributed to the effect of statins’ cholesterol level reduction on brain function.”



Attached files

ID Name Comment Uploaded Size Downloads
7286 Suicidal Dec 2014.pdf PDF admin 04 Nov, 2016 09:46 709.41 Kb 157
6240 Suicide Spring.jpg admin 11 Dec, 2015 18:53 64.60 Kb 1196
4406 Suicide infographic.jpg admin 25 Sep, 2014 12:21 318.54 Kb 1975
4392 Suicide T2.jpg admin 19 Sep, 2014 21:04 59.81 Kb 3381
4391 suicide.jpg admin 19 Sep, 2014 21:04 24.32 Kb 2831
4390 suicidal low D.pdf PDF 2014 admin 19 Sep, 2014 21:03 709.34 Kb 1191
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