Vitamin D that dissolves in mouth helps those having poor response due to poor guts, HSCT etc.
Optimized Vitamin D Repletion in Refractory Patients Undergoing Stem Cell Transplant with Oral Thin Film Cholecalciferol
Blood Adv. 2023 Jun 7;bloodadvances.2023009855. doi: 10.1182/bloodadvances.2023009855
Allison L Bartlett Allison.bartlett@cchmc.org 1, Grace Zhang 2, Gregory Wallace 3, Stacie McLean 3, Kasiani C Myers 1, Ashley Teusink-Cross 3, Cynthia Taggart 4, Bhaumik Patel 5, Robert Davidson 5, Stella M Davies 1, Sonata Jodele 1
1Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
2University of Cincinnati College of Medicine,
3Department of Pharmacy, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH;
4Department of Nutrition Therapy, Cincinnati Children’s Hospital Medical Center,Cincinnati, OH;
5CURE Pharmaceutical, Oxnard, CA
Vitamin D deficiency is common in childhood, pervasive before and after bone marrow transplant, and associated with increased incidence of graft-versus-host disease (GVHD) and decreased survival in patients undergoing hematopoietic stem cell transplantation (HSCT). Numerous barriers impede replacement, including malabsorption secondary to gut GVHD, mucositis, inability to take capsules, kidney disease, liver disease, and infection; many patients remain refractory despite vitamin D therapy. We hypothesized that a different formulation of cholecalciferol, administered on the tongue as a readily dissolving oral thin film (OTF), would ease administration and facilitate therapeutic vitamin D levels (>35 ng/mL) in refractory patients. In this prospective pilot study, we evaluated 20 patients post-HSCT (range: day +21 - day +428 at enrollment) with serum vitamin D levels 📄 Download the PDF from VitaminDWiki
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