Vitamin D levels massively changed by CYP3A4 gene (drugs such as Ivermectin and anti-epileptics)
Deactivation of CYP3A4 by drugs such as IvermectinINCREASE calcitriol and calcidriol (Vitamin D)
Activation of CYP3A4 by drugs (anti-epileptics. Valium etc DECREASE calcitriol and calcidriol (Vitamin D)
Ivermectin raises levels of vitamin D (by decreasing CYP3A4)
Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022
Changes in CYP3A4 gene affects Vitamin D, health, reactions to some drugs, etc - June 2022
Characterization of CYP3A pharmacogenetic variation in American Indian and Alaska Native communities,
targeting CYP3A4*1G allele function. - 📄 PDFInterplay between Vitamin D and the Drug Metabolizing Enzyme CYP3A4 - July 2014 - 📄 PDF
- "For example, daily administration of rifampin (anti-epileptic) to healthy volunteers lowered the plasma concentration of 25OHD3 by 70% "
CYP3A4 mutation causes vitamin D–dependent rickets type 3 - Feb 2018 - 📄 PDF
Role of vitamin D receptor in the regulation of CYP3A gene expression - Nov 2019 - 📄 PDF
VDR regulates CYP3A4 2002 📄 PDF
Valium, Xanax change activation of CYP3A4, which decreases calcitriol and calcidriol 📄 Perplexity AI PDF July 2025
Large doses of flavanoids might reduce activation of CYP3A4 (increasing Vitamin D getting to cells) - 2024 FREE PDF
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CYP3A4 Wikipedia
CYP3A4metabolizes about half of all drugs: examples include:acetaminophen, codeine, ciclosporin (cyclosporin), diazepam, and erythromycin
grapefruit juice ... is a potent inhibitor of CYP3A4, which can affect the metabolism of a variety of drugs, increasing their bioavailability.