[Vitamin D and drugs].

Med Monatsschr Pharm. 2011 Oct;34(10):377-87.

[Article in German]

Gröber U, Holick MF, Kisters K.

Akademie für Mikronährstoffmedizin, Zweigertstr. 55, 45130 Essen. uwegroeber@gmx.net

Interactions between drugs and vitamin D have received only little or no attention in the medical and pharmaceutical world in the past. Since more and more drugs are used for the treatment of patients, this topic is increasingly relevant. As such interactions impact the health of the patient and the action and side effects of the drug, physicians and pharmacists should pay more attention to such interactions in the future.

A number of drugs can interfere with the vitamin D and bone metabolism.

The drug-induced activation of the pregnane X receptor (PXR) is likely to enhance CYP24 expression and the catabolism of 25(OH)D, leading to vitamin D deficiency. PXR-ligands include a wide variety of pharmaceutical agents, such as

• antiepileptic drugs,

• taxol,

• rifampicin, and

• human immunodeficiency virus protease inhibitors such as ritonavir and saquinavir.

Beside this, the medication oriented supplementation of vitamin D can also ameliorate the pharmacologic action of many drugs, such as

• bisphosphonates,

• statins and

• cytostatic drugs.

PMID: 22010421

See also VitaminDWiki

• All items in category Drug interactions with Vitamin D items

• NLM Vitamin D recommendations and interactions – Jan 2011

• Oral contraceptives may reduce vitamin D

• Possible Vitamin D interactions and vicious circles

• Side Effects and Warning for vitamin D

• On-line survey of drug uses and side effects – including vitamin D

• Drugs which create a vitamin D deficiency

• All items in category After Cancer items

• Vitamin D use with Chemotherapy

• #0CF:Allergic reaction to vitamin D is rare Blog post at VitaminDWiki - Feb 2012

• Chemotherapy might be amplified by vitamin D danger - could be fatal

  • Holick: Antiseizure, Prednisone, AIDS drugs, St Johns wort, Orlistat, Questran

  • Zaidi: Dilatin , Phenobarbital, Rifampin, Orlistat, Questran, Steroids

  • And many others