UVB and vitamin D inversely associated with pancreatic cancer
Ultraviolet B Irradiance and Vitamin D Status are Inversely Associated With Incidence Rates of Pancreatic Cancer Worldwide.
Pancreas. 2010 Apr 30. [Epub ahead of print]
Mohr SB, Garland CF, Gorham ED, Grant WB, Garland FC.
From the *Naval Health Research Center, San Diego; daggerDepartment of Family and Preventive Medicine, University of California San Diego, La Jolla; and double daggerSunlight, Nutrition, and Health Research Center, San Francisco, CA.
OBJECTIVES: To determine if an inverse association exits between latitude, ultraviolet B (UVB) irradiance and incidence rates of pancreatic cancer worldwide.
METHODS: Multiple linear regression was used to investigate the relationship and between UVB irradiance incidence rates of pancreatic cancer and while controlling for cigarette, alcohol and sugar consumption, and proportion overweight. Serum 25-hydroxyvitamin D [25(OH)D] levels were estimated, and their association with incidence rates also was analyzed.
RESULTS: Incidence rates were higher at higher latitudes (R for latitude for men, 0.51; P < 0.001; R for latitude for women, 0.32; P < 0.001). Ultraviolet B irradiance also was independently inversely associated with incidence in men (P < 0.01) and women (P = 0.02). Alcohol (P < 0.0001) and cigarette (P 30 ng/mL (75 nmol/L) than in those with
CONCLUSIONS: Countries with lower UVB irradiance had higher incidence rates of pancreatic cancer in both hemispheres, with occasional exceptions. PMID: 20442683