UV reduces cardiovascular and metabolic problems– Vitamin D plus Nitric oxide
Impact of ultraviolet radiation on cardiovascular and metabolic disorders: The role of nitric oxide and vitamin D
Photodermatol Photoimmunol Photomed. 2023 Sep 20. doi: 10.1111/phpp.12914
Qing-Ling Quan 1 2 3, Kyeong-No Yoon 1 2 3, Ji Su Lee 1 2 3, Eun Ju Kim 1 2 3, Dong Hun Lee 1 2 3
Proven benefits in mice
Background/purpose: Ultraviolet (UV) radiation has both harmful and beneficial effects on human skin and health. It causes skin damage, aging, and cancer; however, it is also a primary source of vitamin D. Additionally, UV radiation can impact energy metabolism and has protective effects on several cardiovascular and metabolic disorders in mice and humans. However, the mechanisms of UV protection against these diseases have not been clearly identified.
Methods: This review summarizes the systemic effects of UV radiation on hypertension and several metabolic diseases such as obesity, diabetes, and nonalcoholic fatty liver disease (NAFLD) in mice, and we also consider the mechanisms of action of the related regulators nitric oxide (NO) and vitamin D.
Results: UV exposure can lower blood pressure and prevent the development of cardiovascular diseases and metabolic disorders , such as
metabolic syndrome,
obesity, and
type 2 diabetes,
primarily through mechanisms that depend on UV-induced NO.
UV radiation may also effectively delay the onset of type 1 diabetes through mechanisms that rely on UV-induced vitamin D. UV-induced NO and vitamin D play roles in preventing and slowing the progression of NAFLD.
Conclusion: UV exposure is a promising nonpharmacological intervention for cardiovascular and metabolic disorders. NO and vitamin D may play a crucial role in mediating these effects. However, further investigations are required to elucidate the exact mechanisms and determine the optimal dosage and exposure duration of UV radiation.
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12+ VitaminDWiki pages with NITRIC OXIDE in the title
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VitaminDWiki – Noontime sun and D category:
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VitaminDWiki - studies in both categories Cardiovascular and UV
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VitaminDWiki - studies in both categories Metabolic Syndrome and UV
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VitaminDWiki - studies in both categories Obesity and UV
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