Stroke patients with low vitamin D were 10X more likely to become depressed

Association of Serum 25-Hydroxyvitamin D with Symptoms of Depression After 6 Months in Stroke Patients.

Neurochem Res. 2014 Aug 26. [Epub ahead of print]

Yue W1, Xiang L, Zhang YJ, Ji Y, Li X.

1Department of Neurology, Tianjin Huanhu Hospital, Tianjin, 300060, People's Republic of China.

Our aim was to determine whether there was a relationship between 25-hydroxyvitamin D (25[OH] D) and post-stroke depression (PSD). Two hundred and forty-four ischemic stroke patients admitted to the hospital within the first 24 h after stroke onset were consecutively recruited and followed up for 6 months. Clinical information was collected. Serum 25[OH] D levels were measured at baseline. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for depression at 6-month after stroke.

At 6-month, 91 patients ( 37.3 % ) showed depression and in 60 patients (24.6 %) this depression was classified as major.

There was a significant difference in median serum 25[OH] D levels between PSD patients and no depression cases [8.3 (IQR, 6.8-9.5) vs. 15.6 (IQR, 13.2-20.3) ng/ml, respectively; P < 0.001].

Serum 25[OH] D levels ≤11.2 ng/ml were independently associated with PSD [odds ratio 10.32, 95 % confidence interval 4.97-28.63; P < 0.001], after adjusting for possible confounders.

Serum 25[OH] D levels reduced at admission was found to be associated with PSD. Additional research is needed on vitamin D supplementation to improve the outcome of patients with PSD.

PMID: 25154401

See also VitaminDWiki

• Depression category listing with extensive associated searches

• Post stroke depression 9X more likely if low vitamin D – Dec 2014

• Overview Stroke and vitamin D has the following on depression leading to stroke

  • Article about Brigham Women's Hospital Study which was published in Stroke
  • "women with a history of depression had a 29 percent higher risk of stroke , even after considering other stroke risk factors."
  • "The study included more than 80,000 female nurses between the ages of 54 to 79 years old from 2000-06 without a prior history of stroke. "
  • "More than 1000 cases of stroke were documented among the women during the six years."
• Diseases that may be related via low vitamin D has the following chart: Note that Depression has 5 links to other diseases

See also web

• Post Stroke Depression Wikipedia Aug 2014

• Post-stroke depression (PSD) is considered the most frequent and important neuropsychiatric consequence of stroke. Approximately one-third of stroke survivors experience major depression. Moreover this condition can have an adverse effect on cognitive function, functional recovery and survival.