Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT

Stoss therapy is safe for treatment of vitamin D deficiency in pediatric patients undergoing HSCT

Bone Marrow Transplant. 2021 Apr 19. doi: 10.1038/s41409-021-01294-x

Jessica Bodea 1, Kristen Beebe 2 3, Courtney Campbell 2, Dana Salzberg 2, Holly Miller 2, Roberta Adams 2 3, Lucia Mirea 2, Paul Castillo 4, Biljana Horn 4, Sandhya Bansal 5, Thalachallour Mohanakumar 5, Alexander Ngwube 6 7

Study used 100,000 to 600,000 IU

Vitamin D deficiency remains common among pediatric patients undergoing hematopoietic stem cell transplant (HSCT) despite both aggressive and standard of care strategies. This study examined the safety and efficacy of single high-dose oral vitamin D therapy (Stoss therapy) for treatment of vitamin D deficiency in HSCT recipients. Patients ages 1-21 years presenting for HSCT were randomized to receive either Stoss regimen plus weekly/daily supplementation or standard of care, per US Endocrine Society guidelines. Among the total 48 subjects, 22 (46%) were randomized to Stoss and 26 (54%) to control arms. Baseline 25-hydroxyvitamin D (25-OHD) levels were insufficient/deficient in total of 34 (71%) patients, without difference between treatment groups. The Stoss regimen was well tolerated and no toxicity was observed. At Day +30, mean 25-OHD levels were significantly higher (P = 0.04) with Stoss ( 42.3 ± 12 μg/l) compared to controls ( 35.6 ± 14.3 μg/l), and a higher proportion of Stoss patients had adequate vitamin D levels than controls (85% vs 65%). Stoss therapy is a safe and efficacious treatment option for vitamin D deficiency in children undergoing HSCT and may achieve sufficient levels more rapidly than standard of care.

This trial was registered at www.clinicaltrials.gov as NCT03176849.

• Vitamin D for infants – 100,000 IU monthly is better than 400 IU daily – RCT Oct 2020

• 44 percent of successful RCTs in VitaminDWiki used non-daily dosing - Nov 2020

• Monthly 100,000 IU of vitamin D is safe (and may be better than daily) – RCT Aug 2018

• Monthly vitamin D dosing is better than daily dosing for children and elderly (more likely to be taken) – June 2017

• One pill every two weeks gives you all the vitamin D most adults need

Loading Dose of Vitamin D category has the following

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Better than Daily has the following

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