Role of Vitamin D in human Diseases and Disorders – An Overview – DBP, VDR

International Journal of Pharmacological Research, Vol 4, No 2 (2014)

Priyanshee Gohil, Palak Solanki

Priyanshee Gohil, Assistant Professor, K.B.Institute of Pharmaceutical Education and Research, Gandhinagar, Gujarat, India

Palak Solanki. Department of Pharmacology and Clinical Pharmacy, K. B. Instituteof Pharmaceutical Education & Research, Kadi SarvaVishvavidyalya, Gandhinagar. India

Vitamin D is a fat soluble vitamin and generated in human skin by ultraviolet (UV) light. Today, vitamin D is considered to be a steroidal hormone and plays a central role in bone mineralization and calcium homeostasis. The active form of the vitamin D is 1, 25-dihydroxyvitamin D [1, 25-dihydroxycholecalciferol (DHCC)] which mediates proliferation, differentiation and various functions at the cellular level through Vitamin D receptors (VDR).Therefore, compromised vitamin D status is likely to be involved in progression or pathogenesis of various disorders. This assumption is consistent with findings from epidemiological studies that a compromised vitamin D status in humans increases the risk of autoimmune diseases, such as inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus (SLE), multiple sclerosis and type I diabetes mellitus. However, diseases like cancer, cardiovascular disorders and bone disorders are yet not focused. Thus the role of vitamin D in pathogenesis of various diseases is complex and controversial. This review briefly summarizes the role of vitamin D in development and progression of different human disorders.

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See also VitaminDWiki

• All items in category VDR items

• All items in category DBP items

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• Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014

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• Blacks have lower vitamin D levels, but OK active vitamin D levels (VDBP) - Feb 2015