Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor

Created February 2019

Association of vitamin D receptor gene FokI and TaqI polymorphisms and risk of RDS.

J Matern Fetal Neonatal Med. 2019 Feb 13:1-201. doi: 10.1080/14767058.2019.1582629.

Ustun N1, Eyerci N2, Karadag N1, Yesilyurt A2, Zenciroglu A1, Okumus N1.

1 Neonatology Dr Sami Ulus Maternity and Children's Training and Research Hospital , Ankara , Turkey.

2 Dept of Genetics , Dıskapı Yıldırım Beyatız Education and Training Hospital , Ankara , Turkey.

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BACKGROUND:

Vitamin D and its receptor (VDR) have important roles in perinatal lung development. The objective of this study was to investigate the possible association between VDR FokI and TaqI polymorphism and development of respiratory distress syndrome (RDS) in preterm infants.

METHOD:

A total of 173 premature infants < 34 weeks: 82 with RDS and 91 without RDS were enrolled. Genotyping of VDR polymorphisms were assayed by real-time PCR. Serum 25-hydroxyvitamin D (25-OHD) levels were measured by ELISA in blood samples that were obtained at the time of admission to the neonatal intensive care unit.

RESULTS:

Gestational age (GA) was significantly lower in RDS group compared to the controls. In univariate analysis, VDR TaqI CT and CC genotypes were associated with the increased risk of RDS (OR = 3.264, p = 0.001, 95% CI = 1.597-6.672 and OR = 5.222 , p < 0.001, 95% CI = 2.165-12.597, respectively); while VDR FokI showed no association with RDS. 25-OHD levels in RDS group were significantly lower compared with those in without RDS group (p = 0.002). Serum 25-OHD levels were not significantly different among the different FokI and TaqI genotypes.

CONCLUSIONS:

This is the first report of association of VDR polymorphism with RDS development in preterm neonates. Current study suggests that VDR TaqI polymorphism may be involved in predisposition to RDS in premature neonates. Further studies are needed to assess the contribution of vitamin D and VDR signaling to the pathogenesis RDS.

Tags: Breathing Infant-Child Vit D Receptor