Periodontitis probably related to low Vitamin D – review

Created August 2018

Serum vitamin D levels and chronic periodontitis in adult, Caucasian population—a systematic review

Journal of Periodontal Research, 2018, https://doi.org/10.1111/jre.12560

M. Perić - Cliniques Universitaires Saint-Luc

E. Cavalier - Department of Clinical Chemistry, CHU Sart‐Tilman, University of Liège, Liège, Belgium

S. Toma - Cliniques Universitaires Saint-Luc

It might be that periodontitis, like several other health problems, is more associated with Vitamin D related genes than Vitamin D in the blood. The genes can restrict a good level if Vitamin D in the blood from actually getting to the cells --- Dental category listing has items along with related searches * Generalized Aggressive Periodontitis is 3X more likely if too much Vitamin D-Binding Protein – Nov 2016 * Periodontitis associated with low Vitamin D if dark-skinned – Dec 2018 * Periodontitis treated by 4,000 IU of Vitamin D (pilot study) - March 2019 --- 1. # Items in both categories Dental and Vitamin D Receptor are listed here: {category}

📄 Download the PDF from sci-hub via VitaminDWiki

The aim of this systematic review was to explore the relationship between serum vitamin D levels and periodontal disease. The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The focused PICO question was: Are serum vitamin D levels (I) associated with gingivitis or periodontitis (C) in healthy humans (P)? PubMed (Medline), Embase, Science Direct, the Cochrane library, and grey literature were searched up to 31 July 2017. Two reviewers independently selected studies and extracted data. Quality, risk of bias, and heterogeneity of the studies were assessed using the Newcastle-Ottawa Scale. In total, 365 studies were identified and 24 were analyzed.

Seven studies fulfilled the inclusion criteria.

  • Four case-control studies showed an influence of vitamin D and its metabolites on periodontal health status/disease.

  • One interventional study suggested the proposed anti-inflammatory role of vitamin D.

  • Two cross-sectional studies failed to show a relationship between vitamin D and periodontal condition.

The literature on the effect of serum vitamin D levels on periodontal status remains scarce and controversial. Some data, however, support a "perio-protective" role for vitamin D. There is a need for well-designed randomized clinical trials to explore the possible anti-inflammatory effect of vitamin D on periodontal health.

Some of the references – most recent first

  • Serum levels of 25-hydroxyvitamin D are associated with periodontal disease. Markus Laky, Kristina Bertl, Hady Haririan, Oleh Andrukhov, Rudolf Seemann, Ivo Volf, Alice Assinger, Reinhard Gruber, Andreas Moritz, Xiaohui Rausch-Fan, 2017, Clinical Oral Investigations - Article

  • Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: A call for global action, Maurizio S. Tonetti, Søren Jepsen, Lijian Jin, Joan Otomo‐Corgel, 2017, Journal Of Clinical Periodontology - Article

  • Vitamin D and inflammatory markers: cross-sectional analyses using data from the English Longitudinal Study of Ageing (ELSA), Cesar de Oliveira, Jane P. Biddulph, Vasant Hirani, Ione Jayce Ceola Schneider. 2017, Journal of Nutritional Science - Article

  • Low vitamin D status strongly associated with periodontitis in Puerto Rican adults , Orlando J. Abreu, Dimitris N. Tatakis, Augusto R. Elias-Boneta, Lydia López Del Valle, Rafael Hernandez, Maria S. Pousa, Cristina Palacios, 2016, BMC Oral Health - Article

  • Anti-Inflammatory Effects of Vitamin D on Human Immune Cells in the Context of Bacterial Infection. Edwin Hoe, Jordan Nathanielsz, Zheng Quan Toh, Leena Spry, Rachel Marimla, Anne Balloch, Kim Mulholland, Paul V Licciardi. 2016, Nutrients - Article

  • Host‐derived salivary biomarkers in diagnosing periodontal disease: systematic review and meta‐analysis, Caroline L. Lima, Ana Carolina Acevedo, Daniela C. Grisi, Mario Taba, Eliete Guerra, Graziela De Luca Canto, 2016, Journal Of Clinical Periodontology - Article

  • A phase IV, two-armed, randomized, cross-over study comparing compliance with once-a-month administration of vitamin D3 to compliance with daily administration of a fixed-dose combination of vitamin D3 and calcium during two 6-month periods, O Bruyère, R Deroisy, N Dardenne, E Cavalier, M Coffiner, S Da Silva, S De Niet, J-Y Reginster, 2015, Osteoporosis International - Article

  • Associations Between Serum 25‐Hydroxyvitamin D and Periodontal Pocketing and Gingival Bleeding: Results of a Study in a Non‐Smoking Population in Finland, Georgios N. Antonoglou, Anna Liisa Suominen, Matti Knuuttila, Pekka Ylöstalo, Meeri Ojala, Satu Männistö, Jukka Marniemi, Annamari Lundqvist, Tellervo Tervonen, 2015, Journal of Periodontology - Article

  • Low serum level of 1,25(OH)2D is associated with chronic periodontitis, G. N. Antonoglou, M. Knuuttila, O. Niemelä, T. Raunio, R. Karttunen, O. Vainio, P. Hedberg, P. Ylöstalo, T. Tervonen, 2015, Journal of Periodontal Research - Article

  • Re‐evaluating the role of vitamin D in the periodontium. S. H. Stein, R. Livada, D. A. Tipton, 2014, Journal of Periodontal Research - Article

Tags: Dental