Patent application for a skin cream which enhances production of vitamin D – Holick

Compositions for Providing Vitamin D Year Round and Uses Thereof

Methods for enhancing the ability of an individual, exposed to sunlight, to produce vitamin D via the skin. Pharmaceutical compositions comprising provitamin D and at least one of lumisterol and tachysterol and analogs and derivatives thereof are also disclosed.

Claim 1

A composition comprising a pharmaceutically acceptable carrier and an effective amount of (a) provitamin D or a derivative or analog thereof; (b) at least one of lumisterol and tachysterol or analogs and/or esters thereof, and (c) a pharmaceutically effective carrier, wherein (a) and (b) are present in amounts effective to provide vitamin D or derivatives or analogs and/or esters thereof to an individual at a particular latitude and/or time of the year.

Description

FIELD OF THE INVENTION

^[0001] The invention is in the field of cosmetics and medicinal chemistry. In particular, the present invention relates to topical compositions which provide vitamin D and derivatives thereof throughout the year. The topical compositions of the invention allow a user in the high northern and southern latitudes to produce previtamin D on their skin even when exposed to low energy sunlight in the winter as well as in the morning and evening throughout the year . The compositions comprise provitamin D and at least one of tachysterol and lumisterol, and derivatives and analogs thereof, which photoisomerize to previtamin D, and analogs and derivatives thereof.

SUMMARY OF THE INVENTION

^[0015] The present invention is related to the discovery that topical formulations comprising provitamin D and derivatives and analogs thereof together with at least one of lumisterol and tachysterol and derivatives and analogs thereof are effective means of providing vitamin D to individuals throughout the year. The present invention utilizes the low energy UV photoconversion of lumisterol and tachysterol and derivatives and analogs thereof to previtamin D and derivatives and analogs thereof during the winter months and high energy UV photoconversion of provitamin D and derivatives and analogs thereof to previtamin D and derivatives and analogs thereof in the summer months as a method of producing vitamin D and derivatives and analogs thereof in the skin throughout the year.

Comment by VitaminDWiki

If this works, it will be a real breakthru for getting vitamin D:

1. off season,

2. other than middle of the day (too hot),

3. by seniors

4. perhaps those with dark skins

See also VitaminDWiki

• Who said vitamin D could not be patented

• Search for lumisterol OR tachysterol in VitaminDWiki 34 items as of Nov 2013

• Complex relationship between UVB and vitamin D – April 2012 which contains the following

  • Both pre-vitamin D3 and vitamin D can absorb UV radiation and this can lead to isomerization of these molecules to form inert photoproducts, such as lumisterol, tachysterol and 5,6-transvitamin D3 as well as suprasterol I and II ^[14,15].
• Improved health due to vitamin D fortification in Finland which contains the following
  • In the event of excess UVB radiation, previtamin D3 will be degraded into inactive sterols lumisterol and tachysterol, or be retransformed to 7-DHC

See also web

• tachysterol Definition and how to pronounce the word
  • An isomer of ergosterol that forms vitamin D2 when irradiated with ultraviolet light.