Overview Cancer-Colon and vitamin D

Summary of Colorectal Cancer and Vitamin D:

The title of one study provides a one line summary:
      Vitamin D as a promising anticancer agent (includes colon cancer)

Which VitaminDWiki retitled as
      Vitamin D appears to both PREVENT and TREAT various cancers – Mar 2011

Most people need 2,500 - 4,000 IU of vitamin D the reduce probability of most cancers (including colon) by 60%

      probably need more vitamin D if in a high risk group: dark skin, elderly, far from equator, etc.

Still more vitamin D needed to help treat Cancers, such as Colon Cancer

Vitamin D helps healing after most surgeries items

Vitamin D appears to amplify various Chemotherapy drugs

- - So, DO NOT TAKE EXTRA vitamin D if you have the wrong chemo AND your doctor refuses to reduce the Chemo protocol

VitaminDWiki Colon Cancer

• Cancer - Colon category listing has items along with related searches

• Colon cancer – how vitamin D prevents and treats it – Nov 2014

• Colon cancer risk reduced by many vitamins – 13 percent reduction by Vitamin D – meta-analysis Jan 2015

• Colorectal cancer – need more vitamin D if you have certain genes – Aug 2013

• Hypothesis: low vitamin D increases probability of colon cancer – May 2013

• Pathways that vitamin D prevents and treats colon cancer discovered, 2000 IU needed – Dec 2012

• Colon Cancer vs vitamin D, 30 ng is good - Chart Feb 2013

• After 30 years it still appears that vitamin D deals with colorectal cancer – Oct 2012

• Every 100 IU of additional vitamin D decreased colorectal cancer by 4 percent – Mar 2011

• IBD colorectal Cancer and vitamin D – Jan 2011

• Low vitamin D in blacks increases colorectal cancer deaths 40 % – Cancer Oct 2010

  • Appears that 40% of the reason that blacks have increased colorectal cancer is due to lack of vitamin D

• Increasing vitamin D increases colon cancer in Finnish smokers – Jan 2011

• Reduce colorectal cancer with 1000 IU of vitamin D - April 2010

• Emerging role of vitamin D in colorectal cancer – Aug 2011

• Colorectal cancer 26 percent less likely for every 10 ng of vitamin D – meta-analysis Aug 2011

• Vitamin D prevents colon Cancer - Kallay May 2011.pdf file

• 10 percent of colon cancer linked to a type of vitamin D gene – meta-analysis April 2012

• When advanced Colon Cancer is not treated by Vitamin D – Mar 2012

• Vitamin D monotherapy reduces colorectal cancer but has calcemic side effects – April 2013

• Colon cancer 23 percent less likely if vitamin D levels higher than 30 ng – Dec 2013

• Colorectal Cancer and Vitamin D infographic March 2013 - has the following

VitaminDWiki Cancer

• Overview Cancer and vitamin D

• Meta-graphs of vitamin D and Cancer – Dec 2011 using only 1,000 IU of vitamin D

• Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011

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VitaminDWiki - studies in both categories Cancer - Colon and Intervention

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VitaminDWiki - studies in both categories Colon-Cancer and Mortality

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See also on the web

• Defending against Colon Cancer Hayden 2017
  • 7 reasons why vitamin D helps defend, also discusses diet
• Beyond standard adjuvant therapy for colon cancer: role of nonstandard interventions - Aug 2012
  • full text on-line Vitamin D is one of the interventions which both prevent AND Treat colon cancer
• Diet and Nutrient Factors in Colorectal Cancer Risk Nutrition in Clinical Practice Oct 2012 full free text on-line
  • Nutrition and lack of vitamin D form 30% of the risk of Colon Cancer
  • Vitamin D is 0 to 50% of the risk - limited data
  • Red meat is 30% yo 50% of the risk
• A Tale of Two Drugs MIT Technology Review Oct 2013
  • Zaltrap for colorectal cancer, Similar to previous drug in that it only adds only 1.4 months to life expectancy
  • initially sold by Sanofifor $11,000 a month, but there was a slow adoption rate
  • To encourage prescriptions, doctors and hospitals now get a 50% kickback on the price of the drug - $6,500 a month!, while insurance/govt pays the full price

• Vitamin D receptor gene polymorphisms and colorectal cancer risk: a systematic meta-analysis April 2012 full text on-line

• Vitamin D and colon cancer May 2012

• Vitamin D resistance and colon cancer prevention - March 2012

• Circulating levels of vitamin D and colon and rectal cancer: the Physicians' Health Study and a meta-analysis of prospective studies May 2011 full text on-line

• Colon Cancer at Vitamin D Council

• Colon Cancer Clinical Trial example: 80 to 100 ng of vitamin D

  • Which typically requires >10,000 IU to get to that level so as to TREAT Colon Cancer

• #00F:Clinical Trials of Colon Cancer with vitamin D intervention10 trials listed as of Sept 2017

• WilikPedia has a good description of Colorectal Cancer which mentions Vitamin D

  • A scientific review undertaken by the National Cancer Institute found that vitamin D was beneficial in preventing colorectal cancer,
  • which showed an inverse relationship with blood levels of 80 nmol/L or higher associated with a 72% risk reduction compared with lower than 50 nmol/L.
• Plasma 25-hydroxyvitamin D and risk of colorectal cancer after adjusting for inflammatory markers Aug 2014
  • still about 30% more likely to get Colon Cancer with low vitamin D - even after adjusting for inflammation

Web: CRC - but nothing about Vitamin D

• Colon Cancer diagnoses in age <55 doubled fn 24 years. - March 2023

  • Incidence of 22 health problems related to vitamin D have doubled in a decade

  • Double digit increases in many health problems for those aged 21-36 in just 4 years - April 2019

• Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death - Oct 9, 2022 DOI: 10.1056/NEJMoa2208375

  • " The number needed to invite to undergo screening to prevent one case of colorectal cancer was 455 (95% CI, 270 to 1429). The risk of death from any cause was 11.03% in the invited group and 11.04% in the usual-care group"

• Fat, fibre and cancer risk in African Americans and rural Africans April 2015

  • A-A <==> exchange diet with rural Africans. Big changes in Colon Cancer markers and inflammation in just 2 weeks. Both ways
  • A-A risk 65/100,000 vs rural African 5/100,000
  • No relationship to Vitamin D, Looking at gut bionome.

• 1200 mg Calcium supplementation increased the risk of subsequent polyps March 2018 Free PDF online

• Omega-3 Fats Help Overcome Multi-Drug Resistant Cancer Nov 2013

• Butyrate, Fiber, and Resistant Starch all fight Colon Cancer Dr. Greger Aug 2019

  Colonoscopies are common only in developed countries which pay for the expensive procedure (US)

• Risks vs. Benefits of Colonoscopies Dr/ Greger April 2018

  • "Other developed countries mostly use the stool tests, with only a few recommending colonoscopies or sigmoidoscopies. That may be because most physicians in the world don’t get paid based on how many procedures they do. As one U.S. gastroenterologist put it, “Colonoscopy is the goose that laid the golden egg.”
  • "A New York Times exposé concluded that the reason doctors rake in so much money is less about “top-notch patient care” and more about business plans maximizing revenue, lobbying, marketing, and turf battles"
  •     Happened to check prices for procedures near me
  •     MRI average prices of different cities ranged from $800 to $2,000
  •     Colonscopies prices were all very close to $2,000 - a good indication pf price fixing
  •         Observation April 2018 by Henry Lahore, founder of VitaminDWiki
• The Pros and Cons of Colonoscopies Mercola Dec 2015
  • There are three ways to detect for colon cancer. The US way, colonoscopy, is 10X more likely to have complications, but gives the most kickback to the US doctor.
  • “it’s estimated that doctors make nearly a million more referrals every year than they would have if they there were not personally profiting.”
  • Nothing about vitamin D

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The more vitamin D, the more prevention of Colorectal Cancer

For vitamin D level = 40ng/ml (100 on the chart) the probability of colorectal cancer is reduced by 2/3

3.95D( - 0.541) is the powerlaw in nmols/L fit of vitamin D data from 10 studies

Relation between prediagnostic serum 25-hydroxyvitamin D level and incidence of breast, colorectal, and other cancers

Dr. WB Grant, J Photochem Photobiol B. 2010 Nov 3;101(2):130-6.

See related publications by Dr. Grant Dr. Grant on vitamin D and mortality in VitaminDWiki

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Probability of many diseases falls when vitamin D > 40 ng/ml

CLICK HERE for details on colon cancer prevention and text which can be translated

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Vicious cycle of colon cancer and vitamin D

Low vitamin D increases the probability of colon cancer

Colon cancer reduces the adsorption of vitamin D needed to recover from colon cancer/surgery - see following clip from chart

Previous image was clipped from this chart

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meta-analyses of COLON Cancer and Vitamin D on VitaminDWiki

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Colon Cancer increasing in young adults

Colorectal cancer will be the leading cause of young adult cancer-related deaths by 2030

**Wahington Post May 2025

{FONT(size="17")}* 📄 Download the PDF from VitaminDWiki *{FONT}

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Colorectal Cancer now the # 1 cause of Cancer deaths in males under age 50 (had been 4th) – Feb 2024* CRC: Troubling Mortality Rates for a Preventable Cancer MD Edge "...cancer mortality rates in general, which are twofold higher in Black people compared with White people, particularly for gastric cancer. " Reporting on a study which is in VitaminDWiki - Predicted US Cancer statistics for 2024 - Feb 2024 **---

Increase in Colorectal Cancer in young adults - Feb 2024* Economist *

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5 X increase in Colon Cancer rates (1999-2020) for ages 10-14 - May 2024* Colon Cancer Rises Dramatically Among Children and Teens ** "Hundreds of thousands of kids ages 10 to 19 are now being diagnosed with colorectal cancer every year."

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30 years of Colon Cancer Vitamin D studies ==> but no change in treatment

#090:** short url =__ is.gd/vitdcolon